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Items: 1 to 20 of 82

1.

Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2.

Thomas JB, Vivancos M, Giddings AM, Wiethe RW, Warner KR, Murza A, Besserer-Offroy É, Longpré JM, Runyon SP, Decker AM, Gilmour BP, Sarret P.

ACS Chem Neurosci. 2016 Sep 21;7(9):1225-31. doi: 10.1021/acschemneuro.6b00097. Epub 2016 Jul 13.

PMID:
27359371
2.

Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound.

Thomas JB, Giddings AM, Wiethe RW, Olepu S, Warner KR, Sarret P, Gendron L, Longpre JM, Zhang Y, Runyon SP, Gilmour BP.

J Med Chem. 2014 Jun 26;57(12):5318-32. doi: 10.1021/jm5003843. Epub 2014 Jun 5.

3.

The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2.

Thomas JB, Giddings AM, Olepu S, Wiethe RW, Warner KR, Sarret P, Longpre JM, Runyon SP, Gilmour BP.

Bioorg Med Chem Lett. 2015;25(10):2060-4. doi: 10.1016/j.bmcl.2015.03.083. Epub 2015 Apr 3.

4.

Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2.

Thomas JB, Giddings AM, Wiethe RW, Olepu S, Warner KR, Sarret P, Gendron L, Longpre JM, Zhang Y, Runyon SP, Gilmour BP.

J Med Chem. 2014 Sep 11;57(17):7472-7. doi: 10.1021/jm500857r. Epub 2014 Aug 26.

5.

Potent spinal analgesia elicited through stimulation of NTS2 neurotensin receptors.

Sarret P, Esdaile MJ, Perron A, Martinez J, Stroh T, Beaudet A.

J Neurosci. 2005 Sep 7;25(36):8188-96.

6.

Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2.

Thomas JB, Giddings AM, Olepu S, Wiethe RW, Harris DL, Narayanan S, Warner KR, Sarret P, Longpre JM, Runyon SP, Gilmour BP.

Bioorg Med Chem Lett. 2015 Jan 15;25(2):292-6. doi: 10.1016/j.bmcl.2014.11.047. Epub 2014 Nov 24.

7.

Pharmacology and functional properties of NTS2 neurotensin receptors in cerebellar granule cells.

Sarret P, Gendron L, Kilian P, Nguyen HM, Gallo-Payet N, Payet MD, Beaudet A.

J Biol Chem. 2002 Sep 27;277(39):36233-43. Epub 2002 Jun 25.

8.

NTS1 and NTS2 mediate analgesia following neurotensin analog treatment in a mouse model for visceral pain.

Smith KE, Boules M, Williams K, Richelson E.

Behav Brain Res. 2012 Jun 15;232(1):93-7. doi: 10.1016/j.bbr.2012.03.044. Epub 2012 Apr 5.

PMID:
22504145
9.

NT69L, a novel analgesic, shows synergy with morphine.

Boules M, Shaw A, Liang Y, Barbut D, Richelson E.

Brain Res. 2009 Oct 19;1294:22-8. doi: 10.1016/j.brainres.2009.07.086. Epub 2009 Aug 3.

PMID:
19651107
10.

Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity.

Roussy G, Dansereau MA, Baudisson S, Ezzoubaa F, Belleville K, Beaudet N, Martinez J, Richelson E, Sarret P.

Mol Pain. 2009 Jul 6;5:38. doi: 10.1186/1744-8069-5-38.

11.

Analgesic synergy of neurotensin receptor subtype 2 agonist NT79 and morphine.

Boules M, Johnston H, Tozy J, Smith K, Li Z, Richelson E.

Behav Pharmacol. 2011 Sep;22(5-6):573-81. doi: 10.1097/FBP.0b013e3283474a3a.

PMID:
21691202
12.

Low-affinity neurotensin receptor (NTS2) signaling: internalization-dependent activation of extracellular signal-regulated kinases 1/2.

Gendron L, Perron A, Payet MD, Gallo-Payet N, Sarret P, Beaudet A.

Mol Pharmacol. 2004 Dec;66(6):1421-30. Epub 2004 Sep 10.

PMID:
15361549
13.

Identification and functional characterization of a 5-transmembrane domain variant isoform of the NTS2 neurotensin receptor in rat central nervous system.

Perron A, Sarret P, Gendron L, Stroh T, Beaudet A.

J Biol Chem. 2005 Mar 18;280(11):10219-27. Epub 2005 Jan 6.

14.

The Administration of Levocabastine, a NTS2 Receptor Antagonist, Modifies Na(+), K(+)-ATPase Properties.

Gutnisky A, López Ordieres MG, Rodríguez de Lores Arnaiz G.

Neurochem Res. 2016 Jun;41(6):1274-80. doi: 10.1007/s11064-015-1823-7. Epub 2016 Jan 7.

PMID:
26738992
15.

Neurotensin NTS1 and NTS2 receptor agonists produce anxiolytic-like effects in the 22-kHz ultrasonic vocalization model in rats.

Steele FF 3rd, Whitehouse SC, Aday JS, Prus AJ.

Brain Res. 2017 Mar 1;1658:31-35. doi: 10.1016/j.brainres.2017.01.012. Epub 2017 Jan 12.

PMID:
28089664
16.

Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice.

Bredeloux P, Costentin J, Dubuc I.

Behav Brain Res. 2006 Dec 15;175(2):399-407. Epub 2006 Oct 30.

PMID:
17074405
17.

NT79: A novel neurotensin analog with selective behavioral effects.

Boules M, Liang Y, Briody S, Miura T, Fauq I, Oliveros A, Wilson M, Khaniyev S, Williams K, Li Z, Qi Y, Katovich M, Richelson E.

Brain Res. 2010 Jan 13;1308:35-46. doi: 10.1016/j.brainres.2009.10.050. Epub 2009 Oct 27.

18.

Characterization of neurotensin receptors.

Kitabgi P, Pélaprat D.

Curr Protoc Pharmacol. 2004 May;Chapter 1:Unit 1.29. doi: 10.1002/0471141755.ph0129s24.

PMID:
22294115
19.

Involvement of NTS2 receptors in stress-induced analgesia.

Lafrance M, Roussy G, Belleville K, Maeno H, Beaudet N, Wada K, Sarret P.

Neuroscience. 2010 Mar 17;166(2):639-52. doi: 10.1016/j.neuroscience.2009.12.042. Epub 2009 Dec 24.

PMID:
20035838
20.

Spinal NTS2 receptor activation reverses signs of neuropathic pain.

Tétreault P, Beaudet N, Perron A, Belleville K, René A, Cavelier F, Martinez J, Stroh T, Jacobi AM, Rose SD, Behlke MA, Sarret P.

FASEB J. 2013 Sep;27(9):3741-52. doi: 10.1096/fj.12-225540. Epub 2013 Jun 11.

PMID:
23756650

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