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Upstream Open Reading Frames Differentially Regulate Gene-specific Translation in the Integrated Stress Response.

Young SK, Wek RC.

J Biol Chem. 2016 Aug 12;291(33):16927-35. doi: 10.1074/jbc.R116.733899. Epub 2016 Jun 29. Review.


Translation of 5' leaders is pervasive in genes resistant to eIF2 repression.

Andreev DE, O'Connor PB, Fahey C, Kenny EM, Terenin IM, Dmitriev SE, Cormican P, Morris DW, Shatsky IN, Baranov PV.

Elife. 2015 Jan 26;4:e03971. doi: 10.7554/eLife.03971.


Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation.

Palam LR, Baird TD, Wek RC.

J Biol Chem. 2011 Apr 1;286(13):10939-49. doi: 10.1074/jbc.M110.216093. Epub 2011 Feb 1.


An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation.

Lee YY, Cevallos RC, Jan E.

J Biol Chem. 2009 Mar 13;284(11):6661-73. doi: 10.1074/jbc.M806735200. Epub 2009 Jan 8.


Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response.

Young SK, Palam LR, Wu C, Sachs MS, Wek RC.

J Biol Chem. 2016 Mar 18;291(12):6546-58. doi: 10.1074/jbc.M115.705640. Epub 2016 Jan 27.


Translation Regulation of the Glutamyl-prolyl-tRNA Synthetase Gene EPRS through Bypass of Upstream Open Reading Frames with Noncanonical Initiation Codons.

Young SK, Baird TD, Wek RC.

J Biol Chem. 2016 May 13;291(20):10824-35. doi: 10.1074/jbc.M116.722256. Epub 2016 Mar 21.


TASEP modelling provides a parsimonious explanation for the ability of a single uORF to derepress translation during the integrated stress response.

Andreev DE, Arnold M, Kiniry SJ, Loughran G, Michel AM, Rachinskii D, Baranov PV.

Elife. 2018 Jun 22;7. pii: e32563. doi: 10.7554/eLife.32563.


Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response.

Young SK, Willy JA, Wu C, Sachs MS, Wek RC.

J Biol Chem. 2015 Nov 20;290(47):28257-71. doi: 10.1074/jbc.M115.693184. Epub 2015 Oct 7.


Translation from the 5' untranslated region shapes the integrated stress response.

Starck SR, Tsai JC, Chen K, Shodiya M, Wang L, Yahiro K, Martins-Green M, Shastri N, Walter P.

Science. 2016 Jan 29;351(6272):aad3867. doi: 10.1126/science.aad3867.


Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions.

Zhou D, Palam LR, Jiang L, Narasimhan J, Staschke KA, Wek RC.

J Biol Chem. 2008 Mar 14;283(11):7064-73. doi: 10.1074/jbc.M708530200. Epub 2008 Jan 14.


The h subunit of eIF3 promotes reinitiation competence during translation of mRNAs harboring upstream open reading frames.

Roy B, Vaughn JN, Kim BH, Zhou F, Gilchrist MA, Von Arnim AG.

RNA. 2010 Apr;16(4):748-61. doi: 10.1261/rna.2056010. Epub 2010 Feb 23.


Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors.

Paolini NA, Moore KS, di Summa FM, Fokkema IFAC, 't Hoen PAC, von Lindern M.

PLoS One. 2018 Apr 10;13(4):e0193790. doi: 10.1371/journal.pone.0193790. eCollection 2018.


eIF1 modulates the recognition of suboptimal translation initiation sites and steers gene expression via uORFs.

Fijalkowska D, Verbruggen S, Ndah E, Jonckheere V, Menschaert G, Van Damme P.

Nucleic Acids Res. 2017 Jul 27;45(13):7997-8013. doi: 10.1093/nar/gkx469.


Physical evidence for distinct mechanisms of translational control by upstream open reading frames.

Gaba A, Wang Z, Krishnamoorthy T, Hinnebusch AG, Sachs MS.

EMBO J. 2001 Nov 15;20(22):6453-63.


Regulation of translation initiation by amino acids in eukaryotic cells.

Kimball SR.

Prog Mol Subcell Biol. 2001;26:155-84. Review.


Translational control by 5'-untranslated regions of eukaryotic mRNAs.

Hinnebusch AG, Ivanov IP, Sonenberg N.

Science. 2016 Jun 17;352(6292):1413-6. doi: 10.1126/science.aad9868. Review.


The eukaryotic initiation factor (eIF) 4G HEAT domain promotes translation re-initiation in yeast both dependent on and independent of eIF4A mRNA helicase.

Watanabe R, Murai MJ, Singh CR, Fox S, Ii M, Asano K.

J Biol Chem. 2010 Jul 16;285(29):21922-33. doi: 10.1074/jbc.M110.132027. Epub 2010 May 12.

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