Similar articles for PMID: 27336199

Year	Number of Results
1997	1
2001	1
2003	1
2004	3
2005	2
2006	4
2007	6
2008	4
2009	4
2010	2
2011	5
2012	6
2013	6
2014	9
2015	14
2016	9
2017	11
2018	11
2019	2
2021	1
2024	0

1

Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4'-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein.

Guglielmo S, Lazzarato L, Contino M, Perrone MG, Chegaev K, Carrieri A, Fruttero R, Colabufo NA, Gasco A. Guglielmo S, et al. J Med Chem. 2016 Jul 28;59(14):6729-38. doi: 10.1021/acs.jmedchem.6b00252. Epub 2016 Jul 7. J Med Chem. 2016. PMID: 27336199

2

A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression.

Guglielmo S, Contino M, Lazzarato L, Perrone MG, Blangetti M, Fruttero R, Colabufo NA. Guglielmo S, et al. ChemMedChem. 2016 Feb 17;11(4):374-6. doi: 10.1002/cmdc.201500538. Epub 2016 Jan 21. ChemMedChem. 2016. PMID: 26797828

3

4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators.

Colabufo NA, Berardi F, Cantore M, Perrone MG, Contino M, Inglese C, Niso M, Perrone R, Azzariti A, Simone GM, Paradiso A. Colabufo NA, et al. Bioorg Med Chem. 2008 Apr 1;16(7):3732-43. doi: 10.1016/j.bmc.2008.01.055. Epub 2008 Feb 2. Bioorg Med Chem. 2008. PMID: 18276145

4

Synthesis and biological evaluation of 2,5-disubstituted furan derivatives as P-glycoprotein inhibitors for Doxorubicin resistance in MCF-7/ADR cell.

Li YS, Zhao DS, Liu XY, Liao YX, Jin HW, Song GP, Cui ZN. Li YS, et al. Eur J Med Chem. 2018 May 10;151:546-556. doi: 10.1016/j.ejmech.2018.04.012. Epub 2018 Apr 5. Eur J Med Chem. 2018. PMID: 29656198

5

Design, Biological Evaluation, and Molecular Modeling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-Glycoprotein Ligand Overcoming Multidrug Resistance in Cancer Stem Cells.

Riganti C, Contino M, Guglielmo S, Perrone MG, Salaroglio IC, Milosevic V, Giampietro R, Leonetti F, Rolando B, Lazzarato L, Colabufo NA, Fruttero R. Riganti C, et al. J Med Chem. 2019 Jan 24;62(2):974-986. doi: 10.1021/acs.jmedchem.8b01655. Epub 2019 Jan 9. J Med Chem. 2019. PMID: 30584838 Free article.

6

1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1.

Rullo M, Niso M, Pisani L, Carrieri A, Colabufo NA, Cellamare S, Altomare CD. Rullo M, et al. Eur J Med Chem. 2019 Jan 1;161:433-444. doi: 10.1016/j.ejmech.2018.10.043. Epub 2018 Oct 18. Eur J Med Chem. 2019. PMID: 30384046

7

SAR studies on tetrahydroisoquinoline derivatives: the role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein.

Capparelli E, Zinzi L, Cantore M, Contino M, Perrone MG, Luurtsema G, Berardi F, Perrone R, Colabufo NA. Capparelli E, et al. J Med Chem. 2014 Dec 11;57(23):9983-94. doi: 10.1021/jm501640e. Epub 2014 Nov 20. J Med Chem. 2014. PMID: 25379609

8

New tetrahydroisoquinoline-based P-glycoprotein modulators: decoration of the biphenyl core gives selective ligands.

Contino M, Guglielmo S, Perrone MG, Giampietro R, Rolando B, Carrieri A, Zaccaria D, Chegaev K, Borio V, Riganti C, Zabielska-Koczywąs K, Colabufo NA, Fruttero R. Contino M, et al. Medchemcomm. 2018 Apr 3;9(5):862-869. doi: 10.1039/c8md00075a. eCollection 2018 May 1. Medchemcomm. 2018. PMID: 30108975 Free PMC article.

9

Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors.

Wu Y, Pan M, Dai Y, Liu B, Cui J, Shi W, Qiu Q, Huang W, Qian H. Wu Y, et al. Bioorg Med Chem. 2016 May 15;24(10):2287-97. doi: 10.1016/j.bmc.2016.03.065. Epub 2016 Apr 1. Bioorg Med Chem. 2016. PMID: 27073052

10

Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity.

Teodori E, Dei S, Floriddia E, Perrone MG, Manetti D, Romanelli MN, Contino M, Colabufo NA. Teodori E, et al. ChemMedChem. 2015 Aug;10(8):1339-43. doi: 10.1002/cmdc.201500143. Epub 2015 May 26. ChemMedChem. 2015. PMID: 26012726

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