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Items: 1 to 20 of 98

1.

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing.

Galanos P, Vougas K, Walter D, Polyzos A, Maya-Mendoza A, Haagensen EJ, Kokkalis A, Roumelioti FM, Gagos S, Tzetis M, Canovas B, Igea A, Ahuja AK, Zellweger R, Havaki S, Kanavakis E, Kletsas D, Roninson IB, Garbis SD, Lopes M, Nebreda A, Thanos D, Blow JJ, Townsend P, Sørensen CS, Bartek J, Gorgoulis VG.

Nat Cell Biol. 2016 Jul;18(7):777-89. doi: 10.1038/ncb3378. Epub 2016 Jun 20.

2.

The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function.

Lo PK, Lee JS, Sukumar S.

Cell Signal. 2012 Jan;24(1):316-24. doi: 10.1016/j.cellsig.2011.09.017. Epub 2011 Sep 22.

3.

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.

Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, Livneh Z, Lygerou Z, Chowdhury D, Sørensen CS, Bartek J, Gorgoulis VG.

Genome Biol. 2018 Mar 16;19(1):37. doi: 10.1186/s13059-018-1401-9.

4.

Induction of p21(Waf1/Cip1) by garcinol via downregulation of p38-MAPK signaling in p53-independent H1299 lung cancer.

Yu SY, Liao CH, Chien MH, Tsai TY, Lin JK, Weng MS.

J Agric Food Chem. 2014 Mar 5;62(9):2085-95. doi: 10.1021/jf4037722. Epub 2014 Feb 24.

PMID:
24533688
5.

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing.

Kim Y, Starostina NG, Kipreos ET.

Genes Dev. 2008 Sep 15;22(18):2507-19. doi: 10.1101/gad.1703708.

7.
8.

Yin Yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-cyclin D1 assembly.

Santiago FS, Ishii H, Shafi S, Khurana R, Kanellakis P, Bhindi R, Ramirez MJ, Bobik A, Martin JF, Chesterman CN, Zachary IC, Khachigian LM.

Circ Res. 2007 Jul 20;101(2):146-55. Epub 2007 Jun 7.

PMID:
17556661
9.
10.

Reexpression of hSNF5 in malignant rhabdoid tumor cell lines causes cell cycle arrest through a p21(CIP1/WAF1)-dependent mechanism.

Kuwahara Y, Charboneau A, Knudsen ES, Weissman BE.

Cancer Res. 2010 Mar 1;70(5):1854-65. doi: 10.1158/0008-5472.CAN-09-1922. Epub 2010 Feb 23.

11.

Expression of the p12 subunit of human DNA polymerase δ (Pol δ), CDK inhibitor p21(WAF1), Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cells.

Zhao H, Zhang S, Xu D, Lee MY, Zhang Z, Lee EY, Darzynkiewicz Z.

Cell Cycle. 2014;13(22):3529-40. doi: 10.4161/15384101.2014.958910.

12.

Resistance of primary cultured mouse hepatic tumor cells to cellular senescence despite expression of p16(Ink4a), p19(Arf), p53, and p21(Waf1/Cip1).

Obata M, Imamura E, Yoshida Y, Goto J, Kishibe K, Yasuda A, Ogawa K.

Mol Carcinog. 2001 Sep;32(1):9-18.

PMID:
11568971
13.
14.

LYG-202 inhibits the proliferation of human colorectal carcinoma HCT-116 cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21(WAF1/Cip1) expression.

Liu W, Dai Q, Lu N, Wei L, Ha J, Rong J, Mu R, You Q, Li Z, Guo Q.

Biochem Cell Biol. 2011 Jun;89(3):287-98. doi: 10.1139/O10-162. Epub 2011 Apr 14.

PMID:
21491996
15.

DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression.

Barr AR, Cooper S, Heldt FS, Butera F, Stoy H, Mansfeld J, Novák B, Bakal C.

Nat Commun. 2017 Mar 20;8:14728. doi: 10.1038/ncomms14728.

16.
17.

A clinicopathological study of p53, p21 (WAF1/CIP1) and cyclin D1 expression in human prostate cancers.

Shiraishi T, Watanabe M, Muneyuki T, Nakayama T, Morita J, Ito H, Kotake T, Yatani R.

Urol Int. 1998;61(2):90-4.

PMID:
9873247
18.

p53/p21(CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin.

Huang S, Liu LN, Hosoi H, Dilling MB, Shikata T, Houghton PJ.

Cancer Res. 2001 Apr 15;61(8):3373-81.

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