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Items: 1 to 20 of 88

1.

Characterization of axonal transport defects in Drosophila Huntingtin mutants.

Weiss KR, Littleton JT.

J Neurogenet. 2016 Sep - Dec;30(3-4):212-221. Epub 2016 Jul 22.

2.
3.

Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo.

White JA 2nd, Anderson E, Zimmerman K, Zheng KH, Rouhani R, Gunawardena S.

Hum Mol Genet. 2015 Dec 20;24(25):7182-95. doi: 10.1093/hmg/ddv415. Epub 2015 Oct 8.

4.

Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model.

Zhang S, Feany MB, Saraswati S, Littleton JT, Perrimon N.

Dis Model Mech. 2009 May-Jun;2(5-6):247-66. doi: 10.1242/dmm.000653. Epub 2009 Apr 6.

5.

In-vivo evidence for the disruption of Rab11 vesicle transport by loss of huntingtin.

Power D, Srinivasan S, Gunawardena S.

Neuroreport. 2012 Nov 14;23(16):970-7. doi: 10.1097/WNR.0b013e328359d990.

PMID:
23032403
6.

Pathogenic Huntington Alters BMP Signaling and Synaptic Growth through Local Disruptions of Endosomal Compartments.

Akbergenova Y, Littleton JT.

J Neurosci. 2017 Mar 22;37(12):3425-3439. doi: 10.1523/JNEUROSCI.2752-16.2017. Epub 2017 Feb 24.

7.

Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons.

Sinadinos C, Burbidge-King T, Soh D, Thompson LM, Marsh JL, Wyttenbach A, Mudher AK.

Neurobiol Dis. 2009 May;34(2):389-95. doi: 10.1016/j.nbd.2009.02.012. Epub 2009 Mar 4.

8.

Huntingtin's function in axonal transport is conserved in Drosophila melanogaster.

Zala D, Hinckelmann MV, Saudou F.

PLoS One. 2013;8(3):e60162. doi: 10.1371/journal.pone.0060162. Epub 2013 Mar 28.

9.

Modeling Huntington disease in Drosophila: Insights into axonal transport defects and modifiers of toxicity.

Krench M, Littleton JT.

Fly (Austin). 2013 Oct-Dec;7(4):229-36. doi: 10.4161/fly.26279. Epub 2013 Sep 10.

10.

Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

Lee WC, Yoshihara M, Littleton JT.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3224-9. Epub 2004 Feb 20.

11.

The Drosophila Huntington's disease gene ortholog dhtt influences chromatin regulation during development.

Dietz KN, Di Stefano L, Maher RC, Zhu H, Macdonald ME, Gusella JF, Walker JA.

Hum Mol Genet. 2015 Jan 15;24(2):330-45. doi: 10.1093/hmg/ddu446. Epub 2014 Aug 28.

PMID:
25168387
12.

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease.

Shirendeb UP, Calkins MJ, Manczak M, Anekonda V, Dufour B, McBride JL, Mao P, Reddy PH.

Hum Mol Genet. 2012 Jan 15;21(2):406-20. doi: 10.1093/hmg/ddr475. Epub 2011 Oct 13.

13.

Loss of Huntingtin stimulates capture of retrograde dense-core vesicles to increase synaptic neuropeptide stores.

Bulgari D, Deitcher DL, Levitan ES.

Eur J Cell Biol. 2017 Aug;96(5):402-406. doi: 10.1016/j.ejcb.2017.01.001. Epub 2017 Jan 22.

14.

Drosophila Acyl-CoA synthetase long-chain family member 4 regulates axonal transport of synaptic vesicles and is required for synaptic development and transmission.

Liu Z, Huang Y, Zhang Y, Chen D, Zhang YQ.

J Neurosci. 2011 Feb 9;31(6):2052-63. doi: 10.1523/JNEUROSCI.3278-10.2011.

15.
16.

Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin.

Her LS, Goldstein LS.

J Neurosci. 2008 Dec 10;28(50):13662-72. doi: 10.1523/JNEUROSCI.4144-08.2008.

17.

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.

Zala D, Colin E, Rangone H, Liot G, Humbert S, Saudou F.

Hum Mol Genet. 2008 Dec 15;17(24):3837-46. doi: 10.1093/hmg/ddn281. Epub 2008 Sep 4.

PMID:
18772195
18.

Protective role of Engrailed in a Drosophila model of Huntington's disease.

Mugat B, Parmentier ML, Bonneaud N, Chan HY, Maschat F.

Hum Mol Genet. 2008 Nov 15;17(22):3601-16. doi: 10.1093/hmg/ddn255. Epub 2008 Aug 20.

PMID:
18718937
19.

Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila.

Gunawardena S, Her LS, Brusch RG, Laymon RA, Niesman IR, Gordesky-Gold B, Sintasath L, Bonini NM, Goldstein LS.

Neuron. 2003 Sep 25;40(1):25-40.

20.

The dynamics of early-state transcriptional changes and aggregate formation in a Huntington's disease cell model.

van Hagen M, Piebes DGE, de Leeuw WC, Vuist IM, van Roon-Mom WMC, Moerland PD, Verschure PJ.

BMC Genomics. 2017 May 12;18(1):373. doi: 10.1186/s12864-017-3745-z.

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