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27302464,26214036,30951174,17446185,27967605,18555842,18511502,21874557,18073319,23994519,23994518,17916611,21098736,28639297,25294216,20929977,15605382,11731615,21085043,19686839,31605661,16916918,15878932,32065259,32787533,29049322,28874356,22174785,29046293,28778990,29415899,19401459,22354784,17054661,25083788,18239076,21757760,29104506,36454193,29604268,25673772,29703203,32121211,16014350,28522765,23104933,21817111,31361024,19036883,12563009,27780821,19588229,25648888,31368276,25136584,21352507,24487027,31955265,31265325,20157566,17332058,30030137,17138654,30195320,28177717,24118142,22348463,21543634,22496244,28546467,35588524,28074493,29365291,18669938,23462817,17099248,26438561,20085804,17284668,27094017,16902066,26674215,35102189,31095457,27501182,17962579,23904104,27076782,30858489,19196796,12734114,27231350,22105890,19966219,20015518,28654773,20628026,36717166,26114427,19793954,28317895,31738957,29230719,23460046,33546195,23100029,19859910,23443926,33625690,32880686,15767263,30395971,26656911,30676864,30511338,26869683,29480414,29962089,21590341,25116175,21771965,20032509,29543139,20308248,23690562,35635310,22184011,30259075,23297307,24907054,21945104,32044445,29112628,14633846,19001047,19571205,24280126,29678764,33722744,30105901,19440340,27085781,28177702,26340467,33400973,31794264,30793541,31778310,24146969,20100740,22234788,33566209,20716531,20106991,28271805,29565774,29537859,22272266,19966034,31161726,31228206,19948729,17488713,21307617,31290266,28263310,29215172,23523698,32833332,19286571,21832205,30536041,24947024,31235694,34322871,25987562,15151904,20086318,23836911,20401754,20720174,32375875,29672614,19448709,12777397,29309801,29126696,22308395,29504288,27604398,25009290,19237425,23916840,21679772,23825228,26053857,30218749,19211721,17003473,23650363,28550474,23717545,21698184,28438761,22384185,29812989,29067788,17158179,33939098,21451146,30457682,17702743,32627872,20371735,28400503,29859976,35850762,23951207,29383885,22415879,23086035,23936397,27809412,30359971,15229108,33200398,17971515,29883716,21284983,33118684,25896313,22848618,27875304,31158323,19221126,20383225,22065740,36521568,30777303,31794263,22613742,27738103,32840695,23065759,29855791,27487028,23223635,28467933,21795630,20032281,23333568,20660060,32006566,31085594,33749947,30578580,32529514,23757406,28199417,32414179,27614713,27122157,24000180,30888859,20881246,24430439,24169546,20978344,29675670,23982155,17932564,28715885,30578297,35023763,19460884,23217713,14988240,32105519,17090215,27735783,32087280,31897508,20197054,18220593,19887595,27647415,33260934,36235564,16186060,17932032,30061404,32142766,32862503,34890715,26268822,33273811,33515657,20375275,20849372,24757201,32293073,36142755,35189251,26849960,24638054,33356364,17182725,32372536,19774670,19907002,29225311,31622160,21165677,16282353,31618368,19693513,37062444,32987623,21212094,29730289,30787662,28091624,30982966,24510228,24284795,23537026,22975021,30889894,27833743,30862473,33590008,34131782,24505137,27104889,31242648,28943449,25683949,18434626,23028049,21816448,12163024,23099843,29854769,20571821,29504290,29806860,30649918,32745766,25002036,29111103,23050972,31852198,30221360,31095141,26499800,25022156,35700525,33425220,30233161,24718953,30115854,29727016,30183330,32433820,33369800,28720712,28028076,28259539,14729480,34687403,35670765,30113273,26227152,30726106,36769025,32627238,18347329,24327607,35606458,10974655,15469941,27497229,21331471,30556158,21256215,29602395,25555216,36650315,31444397,26581843,31860387,22627788,29283930,19936205,36680791,21652727,36047095,29549884,30798619,35180801,30690066,36622074,30712161,25494871,25259918,29261667,24277823,30498989,27061106,31039007,29961149,29389248,28223292,20566734,35623315,24610533,31219211,24514907,31469981,35998371,24688216,32079067,28349667,27896503,29789344,29955707,26825520,10212303,20921196,32784428,32729236,35892280,31942994,32164219,33830325,33551001,34603087,21461634,30512989,20458138,34040358,23001918,21106753,33433932,28318397,23538842,25886402,32909059,30424505,25172896,16079133,23687941,34325488,31696200,26943341,27312223,31029787,36322028,27589085,32848060,24371033,28549992,34066911,31512405,21435455,29054764,23161867,25982469,32506826,30829673,31618641,20404331,25549200,30017591,35557975,28439972,19692661,21179212,34290257,33378424,33779293,23922868,23927032,31577158,24534841,31364767,32801267,21237159,23114600,35528525,28398573,34942163,28155812,32562350,33843280,20007520,29280079,23707060,35008572,21335378,34216158,29971668,26159922,24069271,24965795,26625097,32277569,31266022,19763017,33682060,21789886,19918075,33825857,29140431,14664714,33564963,21680746,28857232,27044851,28404597,11519737,24216763,25257453,35163799,28795454,33486096,36414561,23508836,27424777,30540495,21755522,27271583,33233350,27861863,35116125,28951138,22936731,20837639,21109195,30614532,29975600,23175776,33812060,33946753,32936962,29617759,31041745,27932674,34399057,33106833,33746903,23874007,30891782,31786263,20936441,30526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774,29332207,26658171,33597895,25271307,18484352,36311241,11163737,2865042,29690597,28572498,28534495,35276765,33626393,30980266,22675319,34275793,30694975,24501562,31314852,26951149,21614168,31068841,3967768,30788921,21483800,23586759,32707695,29178319,27601998,36231330,30538043,34796134,24757196,7503906,35461977,36136945,12475370,21042574,29531537,29707604,24149887,21224226,36567551,31089557,35411558,30832464,24385698,34281225,24976760,31802473,24563297,36213227,32923947,30873123,20651591,29781744,32909923,27559315,32694831,24798414,22450344,29765854,36583689,24957515,35194789,34594239,36733489,30559167,36148631,27738421,16651727,32436183,29897050,27904582,32495173,24674967,36830059,31473200,34893938,27621662,35108768,26542343,28796154,30890955,21490325,22039463,35816153,34822388,28833133,33958959,28700655,28024113,23258911,24298334,28483784,18288283,34485607,29309051,22500226,31417428,25821434,35484130,24344330,26254272,23110231,33598660,31314461,36775646,26733679,30193453,29367100,26244127,21876836,26441673,34261989,34746826,35911110,35450292,32342449,36714847,33602887,30355976,36997839,36871014,15496480,31247950,31034253,37009228,35172336,34147042,33705956,27069323,35910582,31736784,31337203,19652469,28462117,20563704,24744502,23148693,36930538,34923936,30284737,32449407,28066267,30817317,35888735,32192996,31423321,33584337,36978846,32197405,35886662,25866834,35222093,36042416,4059304,34947924,33859869,29168801,30140721,35918335,35801156,34968235,25206864,29123335,28982654,29602880,35596515,34014404,36467889,28034458,21784791,19584945[uid]

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Thyroid hormone activation by type 2 deiodinase mediates exercise-induced peroxisome proliferator-activated receptor-γ coactivator-1α expression in skeletal muscle.

Bocco BM, Louzada RA, Silvestre DH, Santos MC, Anne-Palmer E, Rangel IF, Abdalla S, Ferreira AC, Ribeiro MO, Gereben B, Carvalho DP, Bianco AC, Werneck-de-Castro JP. Bocco BM, et al. J Physiol. 2016 Sep 15;594(18):5255-69. doi: 10.1113/JP272440. Epub 2016 Aug 18. J Physiol. 2016. PMID: 27302464 Free PMC article.

Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes.

Werneck-de-Castro JP, Fonseca TL, Ignacio DL, Fernandes GW, Andrade-Feraud CM, Lartey LJ, Ribeiro MB, Ribeiro MO, Gereben B, Bianco AC. Werneck-de-Castro JP, et al. Endocrinology. 2015 Oct;156(10):3842-52. doi: 10.1210/en.2015-1246. Epub 2015 Jul 27. Endocrinology. 2015. PMID: 26214036 Free PMC article.

A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice.

Carmody C, Ogawa-Wong AN, Martin C, Luongo C, Zuidwijk M, Sager B, Petersen T, Roginski Guetter A, Janssen R, Wu EY, Bogaards S, Neumann NM, Hau K, Marsili A, Boelen A, Silva JE, Dentice M, Salvatore D, Wagers AJ, Larsen PR, Simonides WS, Zavacki AM. Carmody C, et al. Endocrinology. 2019 May 1;160(5):1205-1222. doi: 10.1210/en.2019-00088. Endocrinology. 2019. PMID: 30951174 Free PMC article.

An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation.

Miura S, Kawanaka K, Kai Y, Tamura M, Goto M, Shiuchi T, Minokoshi Y, Ezaki O. Miura S, et al. Endocrinology. 2007 Jul;148(7):3441-8. doi: 10.1210/en.2006-1646. Epub 2007 Apr 19. Endocrinology. 2007. PMID: 17446185

Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function.

Ignacio DL, Silvestre DH, Anne-Palmer E, Bocco BM, Fonseca TL, Ribeiro MO, Gereben B, Bianco AC, Werneck-de-Castro JP. Ignacio DL, et al. Thyroid. 2017 Apr;27(4):577-586. doi: 10.1089/thy.2016.0392. Epub 2017 Feb 10. Thyroid. 2017. PMID: 27967605 Free PMC article.

Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1alpha protein expressions in rat skeletal muscle.

Suwa M, Nakano H, Radak Z, Kumagai S. Suwa M, et al. Metabolism. 2008 Jul;57(7):986-98. doi: 10.1016/j.metabol.2008.02.017. Metabolism. 2008. PMID: 18555842

Isoform-specific increases in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to beta2-adrenergic receptor activation and exercise.

Miura S, Kai Y, Kamei Y, Ezaki O. Miura S, et al. Endocrinology. 2008 Sep;149(9):4527-33. doi: 10.1210/en.2008-0466. Epub 2008 May 29. Endocrinology. 2008. PMID: 18511502

Mitochondrial biogenesis and PGC-1α deacetylation by chronic treadmill exercise: differential response in cardiac and skeletal muscle.

Li L, Mühlfeld C, Niemann B, Pan R, Li R, Hilfiker-Kleiner D, Chen Y, Rohrbach S. Li L, et al. Basic Res Cardiol. 2011 Nov;106(6):1221-34. doi: 10.1007/s00395-011-0213-9. Epub 2011 Aug 28. Basic Res Cardiol. 2011. PMID: 21874557

PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle.

Leick L, Wojtaszewski JF, Johansen ST, Kiilerich K, Comes G, Hellsten Y, Hidalgo J, Pilegaard H. Leick L, et al. Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E463-74. doi: 10.1152/ajpendo.00666.2007. Epub 2007 Dec 11. Am J Physiol Endocrinol Metab. 2008. PMID: 18073319 Free article.

Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice; impact of PGC-1α.

Ringholm S, Olesen J, Pedersen JT, Brandt CT, Halling JF, Hellsten Y, Prats C, Pilegaard H. Ringholm S, et al. Exp Gerontol. 2013 Nov;48(11):1311-8. doi: 10.1016/j.exger.2013.08.012. Epub 2013 Aug 29. Exp Gerontol. 2013. PMID: 23994519

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