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Items: 1 to 20 of 101


Two Mutually Exclusive Local Chromatin States Drive Efficient V(D)J Recombination.

Bolland DJ, Koohy H, Wood AL, Matheson LS, Krueger F, Stubbington MJ, Baizan-Edge A, Chovanec P, Stubbs BA, Tabbada K, Andrews SR, Spivakov M, Corcoran AE.

Cell Rep. 2016 Jun 14;15(11):2475-87. doi: 10.1016/j.celrep.2016.05.020. Epub 2016 Jun 2.


Insertion of an imprinted insulator into the IgH locus reveals developmentally regulated, transcription-dependent control of V(D)J recombination.

Puget N, Hirasawa R, Hu NS, Laviolette-Malirat N, Feil R, Khamlichi AA.

Mol Cell Biol. 2015 Feb;35(3):529-43. doi: 10.1128/MCB.00235-14. Epub 2014 Nov 17.


Local Chromatin Features Including PU.1 and IKAROS Binding and H3K4 Methylation Shape the Repertoire of Immunoglobulin Kappa Genes Chosen for V(D)J Recombination.

Matheson LS, Bolland DJ, Chovanec P, Krueger F, Andrews S, Koohy H, Corcoran AE.

Front Immunol. 2017 Nov 17;8:1550. doi: 10.3389/fimmu.2017.01550. eCollection 2017.


Control of antigen receptor diversity through spatial regulation of V(D)J recombination.

Ebert A, Medvedovic J, Tagoh H, Schwickert TA, Busslinger M.

Cold Spring Harb Symp Quant Biol. 2013;78:11-21. doi: 10.1101/sqb.2013.78.019943. Epub 2014 Feb 28.


CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning.

Jain S, Ba Z, Zhang Y, Dai HQ, Alt FW.

Cell. 2018 Jun 28;174(1):102-116.e14. doi: 10.1016/j.cell.2018.04.035. Epub 2018 May 24.


Epigenetic modifications of the VH region after DJH recombination in Pro-B cells.

Dong Y, Wu C, Zhao X, Zhang P, Zhang H, Zheng M, Li S, Jiao J, Yu X, Lv Z, Ji Y.

Immunology. 2017 Oct;152(2):218-231. doi: 10.1111/imm.12758. Epub 2017 Jun 23.


Spatial Regulation of V-(D)J Recombination at Antigen Receptor Loci.

Ebert A, Hill L, Busslinger M.

Adv Immunol. 2015;128:93-121. doi: 10.1016/ Epub 2015 Aug 13. Review.


Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination.

Pulivarthy SR, Lion M, Kuzu G, Matthews AG, Borowsky ML, Morris J, Kingston RE, Dennis JH, Tolstorukov MY, Oettinger MA.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6427-E6436. Epub 2016 Oct 3.


Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.

Giallourakis CC, Franklin A, Guo C, Cheng HL, Yoon HS, Gallagher M, Perlot T, Andzelm M, Murphy AJ, Macdonald LE, Yancopoulos GD, Alt FW.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22207-12. doi: 10.1073/pnas.1015954107. Epub 2010 Dec 1.


Differential usage of VH gene segments is mediated by cis elements.

Yu CC, Larijani M, Miljanic IN, Wu GE.

J Immunol. 1998 Oct 1;161(7):3444-54.


Deep sequencing of the murine IgH repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies.

Choi NM, Loguercio S, Verma-Gaur J, Degner SC, Torkamani A, Su AI, Oltz EM, Artyomov M, Feeney AJ.

J Immunol. 2013 Sep 1;191(5):2393-402. doi: 10.4049/jimmunol.1301279. Epub 2013 Jul 29.


Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments.

Hesslein DG, Pflugh DL, Chowdhury D, Bothwell AL, Sen R, Schatz DG.

Genes Dev. 2003 Jan 1;17(1):37-42.


The mouse immunoglobulin heavy chain V-D intergenic sequence contains insulators that may regulate ordered V(D)J recombination.

Featherstone K, Wood AL, Bowen AJ, Corcoran AE.

J Biol Chem. 2010 Mar 26;285(13):9327-38. doi: 10.1074/jbc.M109.098251. Epub 2010 Jan 25.


CTCF-binding elements mediate control of V(D)J recombination.

Guo C, Yoon HS, Franklin A, Jain S, Ebert A, Cheng HL, Hansen E, Despo O, Bossen C, Vettermann C, Bates JG, Richards N, Myers D, Patel H, Gallagher M, Schlissel MS, Murre C, Busslinger M, Giallourakis CC, Alt FW.

Nature. 2011 Sep 11;477(7365):424-30. doi: 10.1038/nature10495.


The Eμ enhancer region influences H chain expression and B cell fate without impacting IgVH repertoire and immune response in vivo.

Marquet M, Garot A, Bender S, Carrion C, Rouaud P, Lecardeur S, Denizot Y, Cogné M, Pinaud E.

J Immunol. 2014 Aug 1;193(3):1171-83. doi: 10.4049/jimmunol.1302868. Epub 2014 Jun 25.


Deep sequencing and Circos analyses of antibody libraries reveal antigen-driven selection of Ig VH genes during HIV-1 infection.

Xiao M, Prabakaran P, Chen W, Kessing B, Dimitrov DS.

Exp Mol Pathol. 2013 Dec;95(3):357-63. doi: 10.1016/j.yexmp.2013.10.004. Epub 2013 Oct 21.


Sequencing of modern Lepus VDJ genes shows that the usage of VHn genes has been retained in both Oryctolagus and Lepus that diverged 12 million years ago.

Pinheiro A, de Mera IG, Alves PC, Gortázar C, de la Fuente J, Esteves PJ.

Immunogenetics. 2013 Nov;65(11):777-84. doi: 10.1007/s00251-013-0728-3. Epub 2013 Aug 24.


Genetic and epigenetic control of V gene rearrangement frequency.

Feeney AJ.

Adv Exp Med Biol. 2009;650:73-81. Review.


How chromatin remodelling allows shuffling of immunoglobulin heavy chain genes.

Bowen AJ, Corcoran AE.

Mol Biosyst. 2008 Aug;4(8):790-8. doi: 10.1039/b719771n. Epub 2008 May 14. Review.


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