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Items: 1 to 20 of 80

1.

Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs.

Bähr A, Käser T, Kemter E, Gerner W, Kurome M, Baars W, Herbach N, Witter K, Wünsch A, Talker SC, Kessler B, Nagashima H, Saalmüller A, Schwinzer R, Wolf E, Klymiuk N.

PLoS One. 2016 May 13;11(5):e0155676. doi: 10.1371/journal.pone.0155676. eCollection 2016.

2.

Differential inhibition of autoreactive memory- and alloreactive naive T cell responses by soluble cytotoxic T lymphocyte antigen 4 (sCTLA4), CTLA4Ig and LEA29Y.

Huurman VA, Unger WW, Koeleman BP, Oaks MK, Chandraker AK, Terpstra OT, Roep BO.

Clin Exp Immunol. 2007 Dec;150(3):487-93. Epub 2007 Oct 9.

3.

Production and characterization of LEA29Y, a variant of cytotoxic T-lymphocyte antigen 4-immunoglobulin, in Pichia pastoris.

Wan L, Zhu S, Li Y, Liu S, Yang H, Li S, Li Y, Cheng J, Lu X.

Appl Microbiol Biotechnol. 2011 Aug;91(3):543-51. doi: 10.1007/s00253-011-3277-4. Epub 2011 Apr 28.

PMID:
21533579
4.

Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T-cell immune response and immune status.

Hara H, Witt W, Crossley T, Long C, Isse K, Fan L, Phelps CJ, Ayares D, Cooper DK, Dai Y, Starzl TE.

Immunology. 2013 Sep;140(1):39-46. doi: 10.1111/imm.12107.

5.

Xenografted islet cell clusters from INSLEA29Y transgenic pigs rescue diabetes and prevent immune rejection in humanized mice.

Klymiuk N, van Buerck L, Bähr A, Offers M, Kessler B, Wuensch A, Kurome M, Thormann M, Lochner K, Nagashima H, Herbach N, Wanke R, Seissler J, Wolf E.

Diabetes. 2012 Jun;61(6):1527-32. doi: 10.2337/db11-1325. Epub 2012 Apr 20.

6.

Human TNF-related apoptosis-inducing ligand-expressing dendritic cells from transgenic pigs attenuate human xenogeneic T cell responses.

Kemter E, Lieke T, Kessler B, Kurome M, Wuensch A, Summerfield A, Ayares D, Nagashima H, Baars W, Schwinzer R, Wolf E.

Xenotransplantation. 2012 Jan-Feb;19(1):40-51. doi: 10.1111/j.1399-3089.2011.00688.x.

PMID:
22360752
7.

Targeting the CD80/CD86 costimulatory pathway with CTLA4-Ig directs microglia toward a repair phenotype and promotes axonal outgrowth.

Louveau A, Nerrière-Daguin V, Vanhove B, Naveilhan P, Neunlist M, Nicot A, Boudin H.

Glia. 2015 Dec;63(12):2298-312. doi: 10.1002/glia.22894. Epub 2015 Jul 27.

PMID:
26212105
8.

Production and characterization of transgenic pigs expressing porcine CTLA4-Ig.

Phelps CJ, Ball SF, Vaught TD, Vance AM, Mendicino M, Monahan JA, Walters AH, Wells KD, Dandro AS, Ramsoondar JJ, Cooper DK, Ayares DL.

Xenotransplantation. 2009 Nov-Dec;16(6):477-85. doi: 10.1111/j.1399-3089.2009.00533.x.

PMID:
20042047
9.

LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapy.

Buerck LW, Schuster M, Oduncu FS, Baehr A, Mayr T, Guethoff S, Abicht J, Reichart B, Klymiuk N, Wolf E, Seissler J.

Sci Rep. 2017 Jun 15;7(1):3572. doi: 10.1038/s41598-017-03913-4.

10.

Glucose metabolism in pigs expressing human genes under an insulin promoter.

Wijkstrom M, Bottino R, Iwase H, Hara H, Ekser B, van der Windt D, Long C, Toledo FG, Phelps CJ, Trucco M, Cooper DK, Ayares D.

Xenotransplantation. 2015 Jan-Feb;22(1):70-9. doi: 10.1111/xen.12145. Epub 2014 Nov 10.

11.

Human T-cell proliferation in response to thrombin-activated GTKO pig endothelial cells.

Ezzelarab C, Ayares D, Cooper DK, Ezzelarab MB.

Xenotransplantation. 2012 Sep-Oct;19(5):311-6. doi: 10.1111/j.1399-3089.2012.00718.x. Epub 2012 Sep 13.

12.

AAV9-mediated engineering of autotransplanted kidney of non-human primates.

Tomasoni S, Trionfini P, Azzollini N, Zentilin L, Giacca M, Aiello S, Longaretti L, Cozzi E, Baldan N, Remuzzi G, Benigni A.

Gene Ther. 2017 May;24(5):308-313. doi: 10.1038/gt.2017.21. Epub 2017 Mar 27.

PMID:
28346435
13.

Transgenic expression of human cytoxic T-lymphocyte associated antigen4-immunoglobulin (hCTLA4Ig) by porcine skin for xenogeneic skin grafting.

Wang Y, Yang HQ, Jiang W, Fan NN, Zhao BT, Ou-Yang Z, Liu ZM, Zhao Y, Yang DS, Zhou XY, Shang HT, Wang LL, Xiang PY, Ge LP, Wei H, Lai LX.

Transgenic Res. 2015 Apr;24(2):199-211. doi: 10.1007/s11248-014-9833-9. Epub 2014 Sep 19.

PMID:
25236862
14.

hCTLA4-Ig transgene expression in keratocytes modulates rejection of corneal xenografts in a pig to non-human primate anterior lamellar keratoplasty model.

Vabres B, Le Bas-Bernardet S, Riochet D, Chérel Y, Minault D, Hervouet J, Ducournau Y, Moreau A, Daguin V, Coulon F, Pallier A, Brouard S, Robson SC, Nottle MB, Cowan PJ, Venturi E, Mermillod P, Brachet P, Galli C, Lagutina I, Duchi R, Bach JM, Blancho G, Soulillou JP, Vanhove B.

Xenotransplantation. 2014 Sep-Oct;21(5):431-43. doi: 10.1111/xen.12107. Epub 2014 Jul 8.

PMID:
25040113
15.

Relative efficiency of porcine and human cytotoxic T-lymphocyte antigen 4 immunoglobulin in inhibiting human CD4+ T-cell responses co-stimulated by porcine and human B7 molecules.

Koshika T, Phelps C, Fang J, Lee SE, Fujita M, Ayares D, Cooper DK, Hara H.

Immunology. 2011 Dec;134(4):386-97. doi: 10.1111/j.1365-2567.2011.03496.x.

16.

Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.

Larsen CP, Pearson TC, Adams AB, Tso P, Shirasugi N, Strobert E, Anderson D, Cowan S, Price K, Naemura J, Emswiler J, Greene J, Turk LA, Bajorath J, Townsend R, Hagerty D, Linsley PS, Peach RJ.

Am J Transplant. 2005 Mar;5(3):443-53.

17.

Production of cloned pigs expressing human thrombomodulin in endothelial cells.

Yazaki S, Iwamoto M, Onishi A, Miwa Y, Hashimoto M, Oishi T, Suzuki S, Fuchimoto D, Sembon S, Furusawa T, Liu D, Nagasaka T, Kuzuya T, Ogawa H, Yamamoto K, Iwasaki K, Haneda M, Maruyama S, Kobayashi T.

Xenotransplantation. 2012 Mar-Apr;19(2):82-91. doi: 10.1111/j.1399-3089.2012.00696.x.

PMID:
22497510
18.

The transgenic cloned pig population with integrated and controllable GH expression that has higher feed efficiency and meat production.

Ju H, Zhang J, Bai L, Mu Y, Du Y, Yang W, Li Y, Sheng A, Li K.

Sci Rep. 2015 May 11;5:10152. doi: 10.1038/srep10152.

19.

Lymphocyte activation as cytokine gene expression and secretion is related to the porcine reproductive and respiratory syndrome virus (PRRSV) isolate after in vitro homologous and heterologous recall of peripheral blood mononuclear cells (PBMC) from pigs vaccinated and exposed to natural infection.

Ferrari L, Martelli P, Saleri R, De Angelis E, Cavalli V, Bresaola M, Benetti M, Borghetti P.

Vet Immunol Immunopathol. 2013 Feb 15;151(3-4):193-206. doi: 10.1016/j.vetimm.2012.11.006. Epub 2012 Nov 19.

PMID:
23228653
20.

Generation and characterization of human heme oxygenase-1 transgenic pigs.

Yeom HJ, Koo OJ, Yang J, Cho B, Hwang JI, Park SJ, Hurh S, Kim H, Lee EM, Ro H, Kang JT, Kim SJ, Won JK, O'Connell PJ, Kim H, Surh CD, Lee BC, Ahn C.

PLoS One. 2012;7(10):e46646. doi: 10.1371/journal.pone.0046646. Epub 2012 Oct 5.

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