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27083398,22072446,29101409,29750829,24877245,31312863,22821893,20564238,21541999,26952010,23456922,25127089,22991256,24781379,26818785,20200967,22492464,26694597,30583766,23044908,23225022,30488275,23179577,20458576,16189253,23179565,19113929,28276092,20044044,22407910,24221453,22728912,29982545,31219580,27651527,28960489,29947865,29750848,32703114,23589163,23100118,17997712,34530172,20564242,24517240,27981337,20593413,18665795,29694676,19837923,21611974,23553299,30503163,24926955,24644043,32519249,27601020,34480663,25959415,26096924,21351150,25779933,30788527,25736166,30658093,22234812,24684466,31870633,25956285,28199411,25851699,17784842,23572415,29154969,23659831,27175044,26896351,27958659,23371055,25398431,17181395,19839766,29624722,30853658,23658040,25326144,31030240,34463054,25867815,28348031,31926840,35059775,19455271,28194480,26123592,25627115,32871273,24643905,23104200,26525593,21305606,24551194,27619649,32599222,30040148,20499376,26537860,17442649,29751130,26273525,28204954,23138338,24146226,20472932,23149277,16847587,20399288,21508142,23509107,28088646,25906240,20719835,26676839,28722691,19888900,36335582,27487454,30140970,29698852,31437567,27638138,20499344,27943408,28034635,31642976,30397770,28074250,31044263,32706399,26924718,28502885,28384358,34647644,29813182,35190851,29967929,34894003,32413110,32791330,29363165,21909729,25645354,27341808,28574653,34283901,28926125,30708186,26686695,22402673,25135580,33502560,32663365,30219479,36347435,30209523,23526463,34836198,29214508,32623638,31761940,24603002,23299863,22638711,28069517,35865318,28224178,33871626,28608571,26964731,27419666,35588681,28882378,27676223,29121215,28652048,29024249,22684498,29457963,30306224,24360196,20395370,31044182,33894786,27387309,28077378,33796067,22718192,24753047,32795679,23460340,19775199,19152051,28558915,22143491,33724539,28795206,21557311,34122326,29960080,32912732,30465090,30998999,34985148,32790196,28929525,34801763,27447366,28256308,24072196,33098299,23344257,34077400,31874226,23541782,34585784,28341899,24566588,20565921,30553854,33128608,37120433,36987872,35852049,22407970,23530948,29281126,30703208,27154435,28921128,30730590,30098418,22357891,25043459,27143111,33766802,30883870,28780520,27121345,29137724,33196852,32948904,30658879,35094426,23142360,32622072,30281863,29382612,30977554,10762194,22213724,20561906,34796540,20870050,29619932,29069380,36243400,32067027,10591835,35249146,27876503,17907921,28694162,36053067,30001459,35895080,18251704,27325126,35274705,27155883,28710506,29489033,10525716,21059422,28336452,36058501,29435659,15257210,32730935,33314313,8344805,28574412,36567328,28614701,29661687,36581259,33359893,20576400,26232375,33578032,27282455,28722129,34455117,20200975,30219833,33777936,29572622,27577725,18800178,30343166,34139389,36217044,20577874,25865349,11446561,24190426,23913668,34278000,33137537,35502758,29725715,28840427,23703921,19653808,30481154,27556581,27083399,34825263,28001453,27186847,24057069,28512004,28791436,33232837,35880628,26273512,21071031,29439698,25412414,25553670,29063213,29709620,7980958,31260520,29748140,29987700,28109138,28899123,31342335,31410876,29044705,33394902,22124539,27572994,33825260,35526827,32582030,28580402,31226529,10573243,10917740,23497802,23553767,22482611,28884881,27875059,23531785,31376535,20713613,31509022,32638468,32224610,32678420,10548822,20188877,31720708,35421614,9673862,22878154,33157283,33950560,31603998,35766873,23322818,10913921,32887616,27243136,29470841,28161589,36261652,27732327,11730253,22095490,30049982,18221526,21308363,35767093,27113527,29984421,28132909,30995279,27830488,27476799,33531205,27130873,22189918,32938479,29218771,29038835,21737853,32816873,25389553,28487133,1790396,35944891,30316812,25783423,11740062,33856703,22190331,27842233,34981566,31051317,22991066,27260021,28246929,31143990,34603213,34571202,24123088,25187117,19953321,23313281,30187285,2024857,9626405,30423123,33800284,27165286,28246926,24200486,10653365,29064579,26187195,34779934,31160147,8275368,21424265,31940278,11462085,30783777,23103330,31187198,30777311,31786624,20685052,17937534,27829192,29160901,33253932,20051275,32409847,34636938,34547523,27788473,31643098,33086213,31280018,25321622,30913320,30997546,23635290,28673637,26328990,23587336,31273389,11175914,25232524,21832117,31472298,35340062,28601243,35773442,27541945,19459783,27729292,31955228,31262529,33278655,31077851,22139709,33860131,34642812,29196764,36604534,4072657,21816790,28916544,20449571,20544178,30201318,19338454,24477380,31815147,20466088,29534998,18550463,29085733,31055118,15772547,9236258,34649202,23275231,30019965,31044180,14678853,23258269,17945688,28979992,30119956,27818743,27951753,9622826,24231904,28276125,24511131,29594493,12665700,24227822,32911468,32623488,20564249,31265923,32829235,34297085,25069706,10433424,32642427,9701476,32205004,12052451,18575949,33865068,3937580,22028933,9356733,24519558,28874773,20499379,21421091,28432379,26610688,30266406,33400004,30527884,23794225,8275369,24752823,9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Deterioration of trabecular plate-rod and cortical microarchitecture and reduced bone stiffness at distal radius and tibia in postmenopausal women with vertebral fractures.

Wang J, Stein EM, Zhou B, Nishiyama KK, Yu YE, Shane E, Guo XE. Wang J, et al. Bone. 2016 Jul;88:39-46. doi: 10.1016/j.bone.2016.04.003. Epub 2016 Apr 12. Bone. 2016. PMID: 27083398 Free PMC article.

Individual trabecula segmentation (ITS)-based morphological analyses and microfinite element analysis of HR-pQCT images discriminate postmenopausal fragility fractures independent of DXA measurements.

Liu XS, Stein EM, Zhou B, Zhang CA, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Cosman F, Nieves J, Shane E, Guo XE. Liu XS, et al. J Bone Miner Res. 2012 Feb;27(2):263-72. doi: 10.1002/jbmr.562. J Bone Miner Res. 2012. PMID: 22072446 Free PMC article.

Characterization of trabecular bone microstructure in premenopausal women with distal radius fractures.

Rozental TD, Johannesdottir F, Kempland KC, Bouxsein ML. Rozental TD, et al. Osteoporos Int. 2018 Feb;29(2):409-419. doi: 10.1007/s00198-017-4293-8. Epub 2017 Nov 3. Osteoporos Int. 2018. PMID: 29101409

Robust Trabecular Microstructure in Type 2 Diabetes Revealed by Individual Trabecula Segmentation Analysis of HR-pQCT Images.

Starr JF, Bandeira LC, Agarwal S, Shah AM, Nishiyama KK, Hu Y, McMahon DJ, Guo XE, Silverberg SJ, Rubin MR. Starr JF, et al. J Bone Miner Res. 2018 Sep;33(9):1665-1675. doi: 10.1002/jbmr.3465. Epub 2018 Jun 15. J Bone Miner Res. 2018. PMID: 29750829 Free PMC article.

Skeletal structure in postmenopausal women with osteopenia and fractures is characterized by abnormal trabecular plates and cortical thinning.

Stein EM, Kepley A, Walker M, Nickolas TL, Nishiyama K, Zhou B, Liu XS, McMahon DJ, Zhang C, Boutroy S, Cosman F, Nieves J, Guo XE, Shane E. Stein EM, et al. J Bone Miner Res. 2014;29(5):1101-9. doi: 10.1002/jbmr.2144. J Bone Miner Res. 2014. PMID: 24877245 Free PMC article. Clinical Trial.

The association between prevalent vertebral fractures and bone quality of the distal radius and distal tibia as measured with HR-pQCT in postmenopausal women with a recent non-vertebral fracture at the Fracture Liaison Service.

Vranken L, Wyers CE, van Rietbergen B, Driessen JHM, Geusens PPMM, Janzing HMJ, van der Velde RY, van den Bergh JPW. Vranken L, et al. Osteoporos Int. 2019 Sep;30(9):1789-1797. doi: 10.1007/s00198-019-05081-9. Epub 2019 Jul 17. Osteoporos Int. 2019. PMID: 31312863 Free PMC article.

Microarchitectural abnormalities are more severe in postmenopausal women with vertebral compared to nonvertebral fractures.

Stein EM, Liu XS, Nickolas TL, Cohen A, McMahon DJ, Zhou B, Zhang C, Kamanda-Kosseh M, Cosman F, Nieves J, Guo XE, Shane E. Stein EM, et al. J Clin Endocrinol Metab. 2012 Oct;97(10):E1918-26. doi: 10.1210/jc.2012-1968. Epub 2012 Jul 20. J Clin Endocrinol Metab. 2012. PMID: 22821893 Free PMC article.

Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures.

Stein EM, Liu XS, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Zhang C, Yin PT, Cosman F, Nieves J, Guo XE, Shane E. Stein EM, et al. J Bone Miner Res. 2010 Dec;25(12):2572-81. doi: 10.1002/jbmr.152. Epub 2010 Jun 18. J Bone Miner Res. 2010. PMID: 20564238 Free PMC article.

Finite element analysis performed on radius and tibia HR-pQCT images and fragility fractures at all sites in men.

Vilayphiou N, Boutroy S, Szulc P, van Rietbergen B, Munoz F, Delmas PD, Chapurlat R. Vilayphiou N, et al. J Bone Miner Res. 2011 May;26(5):965-73. doi: 10.1002/jbmr.297. J Bone Miner Res. 2011. PMID: 21541999 Free article.

Young adults with cystic fibrosis have altered trabecular microstructure by ITS-based morphological analysis.

Putman MS, Greenblatt LB, Sicilian L, Uluer A, Lapey A, Sawicki G, Gordon CM, Bouxsein ML, Finkelstein JS. Putman MS, et al. Osteoporos Int. 2016 Aug;27(8):2497-505. doi: 10.1007/s00198-016-3557-z. Epub 2016 Mar 7. Osteoporos Int. 2016. PMID: 26952010 Free PMC article.

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