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27062340,32970934,21343549,20439648,26796102,33491606,26676635,29961066,31694105,20368543,28070990,21670448,18559874,29806051,22417203,22753902,21967546,28923882,31350825,29286103,29904089,23701943,28830460,21596848,28318150,18450602,25412851,32699322,31302905,20368538,22914610,26375248,15746041,34270876,33765335,33812399,25609058,29310020,26436590,27050425,34893102,24711548,30190467,32728112,32027246,32476595,22362118,30942411,22077061,27436336,17577018,21744003,27470916,30082223,29079128,22289988,27626217,29786546,29309772,26547258,26298771,31171000,26692090,28100593,36610002,31698462,27636548,21343560,25022553,34481124,28250006,27288520,23540998,27359055,26315090,24801015,34288448,24074521,26234722,24054719,27247325,22821298,26386075,22430270,21538063,22731647,29573577,27276561,28152414,31848884,27476855,24512939,29563537,29180507,22568493,27285584,32090321,31648321,21881046,21372155,22012066,24743218,34617422,32730663,32124426,34238278,31471587,33149230,34700049,27784745,32552938,22490330,31149783,24142997,24565682,33971800,33839881,32019476,21067377,22081665,36066283,33250015,22912701,33891561,29408852,12351377,33433047,29193057,21596855,33913388,21791472,30701458,31348835,21134981,30922328,29601269,29491461,27012040,30303964,32923093,31835432,24898826,25152118,22855599,22520341,27881874,23979985,30126426,33706968,20592250,33711909,31184605,28039446,29472722,19623175,28676493,25648021,25650308,23929217,31018948,31099482,33067935,19171880,28753595,22915647,33879827,34070898,23956224,35967966,29803615,21205756,26162409,30341277,20522712,34855461,31932844,19808697,28002793,35314954,24609756,21960591,34374210,33299888,30793839,31808755,31921515,32568101,30093399,20442368,18378853,31638252,21937695,27034432,32811132,33232873,30662003,32796597,31350639,33476656,31515775,31900500,30970181,28548938,30325535,30190345,30893351,26466372,28596259,25592687,33277314,28980058,32561839,33089315,31648334,31373163,30935386,19822134,29766829,30954792,31111287,32176633,29692343,29727824,29721667,32461631,29393096,30305534,33271547,30089730,35610628,36951195,27174585,36672386,29472724,28882949,21826063,31901183,34453673,33594052,34789078,24378410,31264431,23358744,30968396,31821383,33351131,30199909,21861206,30309854,23313659,32977829,21632498,34664783,31015209,36476886,31467542,33106665,28111462,23704090,31055804,34989829,25586381,28249600,31875988,32934818,33909614,31278736,31344987,26820131,30896832,24072101,33283233,31440963,35652795,20063545,35086749,36751002,36799265,30348947,36653696,28197208,27991732,32599434,29988143,19657110,33915454,25381129,28302711,33006448,26239249,32231866,33161783,34894858,34627254,25266220,31794134,31004019,33594945,32826488,31570689,36753372,29227476,30504289,32417762,21354046,23634996,30673813,32552936,34148032,32027256,25214041,33636567,31477806,32062360,36793248,33675187,33333221,21125345,34376804,25311742,32164600,32862280,31377458,33467898,33036275,36291567,23613835,32306411,31856443,20060365,31163594,31822038,32572947,34818692,31105032,31533653,32246042,22425908,31605801,27951719,33592582,33973643,31371380,31409822,36972938,29506270,29725008,30480765,35653850,23702683,18506749,31673932,32231256,19525338,33998238,30997856,34560908,23595294,29505696,31820579,31645648,27913501,33237942,33931648,29025912,31719678,29519869,34551411,24857122,32943750,26426250,31808906,26091827,31242922,20525753,28369773,23200536,35805006,35967564,29622659,32376287,35558161,24923295,30504290,30700251,26941285,35933981,30809850,34671005,35117330,30213460,31509472,32127641,31077215,33816079,35227274,33676768,32349161,32655615,26376842,31880804,29625580,33648805,32776271,34854833,29455198,31086779,22081445,22791509,31356696,34288423,23184342,30203623,31719049,32318829,33058194,28273185,30529680,25499761,34020042,30760869,25017477,15646648,34655717,31279531,18403605,30576870,23407549,24755948,34504191,27903959,30171717,34229733,32068246,25736313,32188030,37002311,32869672,32711424,30420649,32654462,34339537,35869818,34507566,35092380,35390143,33536020,33535139,33369136,25006128,30840646,35216478,30245083,32706071,32446181,30923100,30428571,32535947,35241089,29562441,31509748,34497237,31449347,36805445,29095060,21080971,30401833,23178814,24806698,33957373,31391376,32552126,22096254,35836575,37088137,34304778,36964937,33650111,27766616,35566503,35231988,22237025,32581253,31650199,25435113,34660311,34448812,33560403,24246700,21917154,24659319,30606702,36865386,32056080,31876540,23358589,30520015,33081843,28440963,30927073,29988082,34001134,32698349,22157292,31936215,33202495,31709191,31575857,30185817,32813587,19650672,31235852,31972687,18270328,31413100,34778799,34333045,23613680,32868804,23716555,30199869,35899387,24474533,30302215,31751678,36997950,34431364,35303493,31965270,32690020,30827681,31932899,26965440,23686445,20929327,36739388,36102349,31723759,34731724,37096544,30231330,25515963,26660431,31779979,30466750,27208809,36568206,32024824,36937458,32759975,30697529,36824144,36921727,36240453,34562306,24639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Results by year

Year	Number of Results
1987	1
1989	1
2002	1
2004	1
2005	1
2007	2
2008	10
2009	9
2010	15
2011	30
2012	33
2013	35
2014	41
2015	35
2016	40
2017	48
2018	86
2019	144
2020	136
2021	131
2022	83
2023	42
2024	0

804 results

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Results by year

Page 1

Mutational spectrum and risk stratification of intermediate-risk acute myeloid leukemia patients based on next-generation sequencing.

Wang B, Liu Y, Hou G, Wang L, Lv N, Xu Y, Xu Y, Wang X, Xuan Z, Jing Y, Li H, Jin X, Deng A, Wang L, Gao X, Dou L, Liang J, Chen C, Li Y, Yu L. Wang B, et al. Oncotarget. 2016 May 31;7(22):32065-78. doi: 10.18632/oncotarget.7028. Oncotarget. 2016. PMID: 27062340 Free PMC article.

Characteristics and prognostic significance of genetic mutations in acute myeloid leukemia based on a targeted next-generation sequencing technique.

Wang RQ, Chen CJ, Jing Y, Qin JY, Li Y, Chen GF, Zhou W, Li YH, Wang J, Li DW, Zhao HM, Wang BH, Wang LL, Wang H, Wang MZ, Gao XN, Yu L. Wang RQ, et al. Cancer Med. 2020 Nov;9(22):8457-8467. doi: 10.1002/cam4.3467. Epub 2020 Sep 24. Cancer Med. 2020. PMID: 32970934 Free PMC article.

TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study.

Metzeler KH, Maharry K, Radmacher MD, Mrózek K, Margeson D, Becker H, Curfman J, Holland KB, Schwind S, Whitman SP, Wu YZ, Blum W, Powell BL, Carter TH, Wetzler M, Moore JO, Kolitz JE, Baer MR, Carroll AJ, Larson RA, Caligiuri MA, Marcucci G, Bloomfield CD. Metzeler KH, et al. J Clin Oncol. 2011 Apr 1;29(10):1373-81. doi: 10.1200/JCO.2010.32.7742. Epub 2011 Feb 22. J Clin Oncol. 2011. PMID: 21343549 Free PMC article. Clinical Trial.

Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations.

Green CL, Koo KK, Hills RK, Burnett AK, Linch DC, Gale RE. Green CL, et al. J Clin Oncol. 2010 Jun 1;28(16):2739-47. doi: 10.1200/JCO.2009.26.2501. Epub 2010 May 3. J Clin Oncol. 2010. PMID: 20439648

Clinical evaluation of panel testing by next-generation sequencing (NGS) for gene mutations in myeloid neoplasms.

Au CH, Wa A, Ho DN, Chan TL, Ma ES. Au CH, et al. Diagn Pathol. 2016 Jan 22;11:11. doi: 10.1186/s13000-016-0456-8. Diagn Pathol. 2016. PMID: 26796102 Free PMC article.

Next-generation sequencing reveals gene mutations landscape and clonal evolution in patients with acute myeloid leukemia.

Chen X, Zhu H, Qiao C, Zhao S, Liu L, Wang Y, Jin H, Qian S, Wu Y. Chen X, et al. Hematology. 2021 Dec;26(1):111-122. doi: 10.1080/16078454.2020.1858610. Hematology. 2021. PMID: 33491606

The prevalence and clinical profiles of FLT3-ITD, FLT3-TKD, NPM1, C-KIT, DNMT3A, and CEBPA mutations in a cohort of patients with de novo acute myeloid leukemia from southwest China.

Gou H, Zhou J, Ye Y, Hu X, Shang M, Zhang J, Zhao Z, Peng W, Zhou Y, Zhou Y, Song X, Lu X, Ying B. Gou H, et al. Tumour Biol. 2016 Jun;37(6):7357-70. doi: 10.1007/s13277-015-4601-x. Epub 2015 Dec 16. Tumour Biol. 2016. PMID: 26676635

Clinical and Biological Implications of Mutational Spectrum in Acute Myeloid Leukemia of FAB Subtypes M0 and M1.

Cheng Z, Dai Y, Pang Y, Jiao Y, Zhao H, Wu S, Zhang L, Zhang Y, Wang X, Wang L, Ma D, Qin T, Hu N, Zhang Y, Hu K, Zhang Q, Shi J, Fu L. Cheng Z, et al. Cell Physiol Biochem. 2018;47(5):1853-1861. doi: 10.1159/000491065. Epub 2018 Jun 29. Cell Physiol Biochem. 2018. PMID: 29961066 Free article. Clinical Trial.

[Using next generation sequencing technology to analyze gene mutations in patients with acute myeloid leukemia and the impact on prognosis].

Zhao CX, Wang JM, Li JM, Zou SH, Chen FY, Liang AB, Hou J, Hu XX, Zhang YX, Gu SY, Zhu JY, Li P, Du J, Yang YN, Qin YW, Wang XR, Wang C. Zhao CX, et al. Zhonghua Yi Xue Za Zhi. 2019 Oct 29;99(40):3145-3151. doi: 10.3760/cma.j.issn.0376-2491.2019.40.005. Zhonghua Yi Xue Za Zhi. 2019. PMID: 31694105 Chinese.

IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.

Marcucci G, Maharry K, Wu YZ, Radmacher MD, Mrózek K, Margeson D, Holland KB, Whitman SP, Becker H, Schwind S, Metzeler KH, Powell BL, Carter TH, Kolitz JE, Wetzler M, Carroll AJ, Baer MR, Caligiuri MA, Larson RA, Bloomfield CD. Marcucci G, et al. J Clin Oncol. 2010 May 10;28(14):2348-55. doi: 10.1200/JCO.2009.27.3730. Epub 2010 Apr 5. J Clin Oncol. 2010. PMID: 20368543 Free PMC article.

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