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Items: 1 to 20 of 105

1.

PEDF inhibits pancreatic tumorigenesis by attenuating the fibro-inflammatory reaction.

Principe DR, DeCant B, Diaz AM, Mangan RJ, Hwang R, Lowy A, Shetuni BB, Sreekumar BK, Chung C, Bentrem DJ, Munshi HG, Jung B, Grippo PJ, Bishehsari F.

Oncotarget. 2016 May 10;7(19):28218-34. doi: 10.18632/oncotarget.8587.

2.

The Role of PEDF in Pancreatic Cancer.

Ansari D, Althini C, Ohlsson H, Bauden M, Andersson R.

Anticancer Res. 2019 Jul;39(7):3311-3315. doi: 10.21873/anticanres.13473. Review.

PMID:
31262851
3.

Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice.

Grippo PJ, Fitchev PS, Bentrem DJ, Melstrom LG, Dangi-Garimella S, Krantz SB, Heiferman MJ, Chung C, Adrian K, Cornwell ML, Flesche JB, Rao SM, Talamonti MS, Munshi HG, Crawford SE.

Gut. 2012 Oct;61(10):1454-64. doi: 10.1136/gutjnl-2011-300821. Epub 2012 Jan 10.

PMID:
22234980
4.

Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway.

He X, Cheng R, Park K, Benyajati S, Moiseyev G, Sun C, Olson LE, Yang Y, Eby BK, Lau K, Ma JX.

Kidney Int. 2017 Mar;91(3):642-657. doi: 10.1016/j.kint.2016.09.036. Epub 2016 Dec 1.

5.

Pigment epithelium-derived factor associates with neuropathy and fibrosis in pancreatic cancer.

Samkharadze T, Erkan M, Reiser-Erkan C, Demir IE, Kong B, Ceyhan GO, Michalski CW, Esposito I, Friess H, Kleeff J.

Am J Gastroenterol. 2011 May;106(5):968-80. doi: 10.1038/ajg.2010.479. Epub 2011 Jan 11.

PMID:
21224836
6.

Pigment Epithelium-derived Factor (PEDF) Blocks Wnt3a Protein-induced Autophagy in Pancreatic Intraepithelial Neoplasms.

Gong J, Belinsky G, Sagheer U, Zhang X, Grippo PJ, Chung C.

J Biol Chem. 2016 Oct 14;291(42):22074-22085. Epub 2016 Aug 24.

7.

Pigment epithelium-derived factor gene therapy inhibits human pancreatic cancer in mice.

Hase R, Miyamoto M, Uehara H, Kadoya M, Ebihara Y, Murakami Y, Takahashi R, Mega S, Li L, Shichinohe T, Kawarada Y, Kondo S.

Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8737-44.

8.

Increased expression of pigment epithelium-derived factor in aged mesenchymal stem cells impairs their therapeutic efficacy for attenuating myocardial infarction injury.

Liang H, Hou H, Yi W, Yang G, Gu C, Lau WB, Gao E, Ma X, Lu Z, Wei X, Pei J, Yi D.

Eur Heart J. 2013 Jun;34(22):1681-90. doi: 10.1093/eurheartj/ehr131. Epub 2011 May 23.

9.

Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization.

Park K, Jin J, Hu Y, Zhou K, Ma JX.

Am J Pathol. 2011 Feb;178(2):688-98. doi: 10.1016/j.ajpath.2010.10.014.

10.

Pigment epithelium-derived factor reduces apoptosis and pro-inflammatory cytokine gene expression in a murine model of focal retinal degeneration.

Wang Y, Subramanian P, Shen D, Tuo J, Becerra SP, Chan CC.

ASN Neuro. 2013 Nov 26;5(5):e00126. doi: 10.1042/AN20130028.

11.

Pigment epithelial growth factor suppresses inflammation by modulating macrophage activation.

Zamiri P, Masli S, Streilein JW, Taylor AW.

Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3912-8.

PMID:
16936104
12.

Pigment epithelium-derived factor regulates early pancreatic fibrotic responses and suppresses the profibrotic cytokine thrombospondin-1.

Schmitz JC, Protiva P, Gattu AK, Utsumi T, Iwakiri Y, Neto AG, Quinn M, Cornwell ML, Fitchev P, Lugea A, Crawford SE, Chung C.

Am J Pathol. 2011 Dec;179(6):2990-9. doi: 10.1016/j.ajpath.2011.08.009. Epub 2011 Sep 28.

13.

Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.

Gattu AK, Birkenfeld AL, Iwakiri Y, Jay S, Saltzman M, Doll J, Protiva P, Samuel VT, Crawford SE, Chung C.

Endocrinology. 2014 Apr;155(4):1373-85. doi: 10.1210/en.2013-1785. Epub 2014 Jan 23.

15.

TGFβ Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis.

Principe DR, DeCant B, Mascariñas E, Wayne EA, Diaz AM, Akagi N, Hwang R, Pasche B, Dawson DW, Fang D, Bentrem DJ, Munshi HG, Jung B, Grippo PJ.

Cancer Res. 2016 May 1;76(9):2525-39. doi: 10.1158/0008-5472.CAN-15-1293. Epub 2016 Mar 15.

16.

Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin.

Hong H, Zhou T, Fang S, Jia M, Xu Z, Dai Z, Li C, Li S, Li L, Zhang T, Qi W, Bardeesi AS, Yang Z, Cai W, Yang X, Gao G.

Breast Cancer Res Treat. 2014 Nov;148(1):61-72. doi: 10.1007/s10549-014-3154-9. Epub 2014 Oct 5.

PMID:
25284724
17.

Pigment epithelium-derived factor (PEDF) binds to caveolin-1 and inhibits the pro-inflammatory effects of caveolin-1 in endothelial cells.

Matsui T, Higashimoto Y, Taira J, Yamagishi S.

Biochem Biophys Res Commun. 2013 Nov 15;441(2):405-10. doi: 10.1016/j.bbrc.2013.10.074. Epub 2013 Oct 23.

PMID:
24161393
18.

Pigment epithelium-derived factor is an intrinsic antifibrosis factor targeting hepatic stellate cells.

Ho TC, Chen SL, Shih SC, Wu JY, Han WH, Cheng HC, Yang SL, Tsao YP.

Am J Pathol. 2010 Oct;177(4):1798-811. doi: 10.2353/ajpath.2010.091085. Epub 2010 Aug 13.

19.

Pigment epithelium-derived factor as a multifunctional regulator of wound healing.

Wietecha MS, Król MJ, Michalczyk ER, Chen L, Gettins PG, DiPietro LA.

Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H812-26. doi: 10.1152/ajpheart.00153.2015. Epub 2015 Jul 10.

20.

Pigment epithelium-derived factor mediates impaired lung vascular development in neonatal hyperoxia.

Chetty A, Bennett M, Dang L, Nakamura D, Cao GJ, Mujahid S, Volpe M, Herman I, Becerra SP, Nielsen HC.

Am J Respir Cell Mol Biol. 2015 Mar;52(3):295-303. doi: 10.1165/rcmb.2013-0229OC.

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