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Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals.

Cooley SA, Paul RH, Fennema-Notestine C, Morgan EE, Vaida F, Deng Q, Chen JA, Letendre S, Ellis R, Clifford DB, Marra CM, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Simpson DM, Morgello S, Grant I, Ances BM; CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) Group.

J Neurovirol. 2016 Oct;22(5):607-614. Epub 2016 Mar 28.


Modulation on brain gray matter activity and white matter integrity by APOE ε4 risk gene in cognitively intact elderly: A multimodal neuroimaging study.

Cai S, Jiang Y, Wang Y, Wu X, Ren J, Lee MS, Lee S, Huang L.

Behav Brain Res. 2017 Mar 30;322(Pt A):100-109. doi: 10.1016/j.bbr.2017.01.027. Epub 2017 Jan 17.


Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism.

Nielsen HM, Chen K, Lee W, Chen Y, Bauer RJ 3rd, Reiman E, Caselli R, Bu G.

Alzheimers Res Ther. 2017 Jan 30;9(1):5. doi: 10.1186/s13195-016-0231-9.


Impact of Apolipoprotein E4 Polymorphism on the Gray Matter Volume and the White Matter Integrity in Subjective Memory Impairment without White Matter Hyperintensities: Voxel-Based Morphometry and Tract-Based Spatial Statistics Study under 3-Tesla MRI.

Lee YM, Ha JK, Park JM, Lee BD, Moon E, Chung YI, Kim JH, Kim HJ, Mun CW, Kim TH, Kim YH.

J Neuroimaging. 2016 Jan-Feb;26(1):144-9. doi: 10.1111/jon.12207. Epub 2015 Feb 11.


Apolipoprotein E genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease.

Lautner R, Palmqvist S, Mattsson N, Andreasson U, Wallin A, Pålsson E, Jakobsson J, Herukka SK, Owenius R, Olsson B, Hampel H, Rujescu D, Ewers M, Landén M, Minthon L, Blennow K, Zetterberg H, Hansson O; Alzheimer’s Disease Neuroimaging Initiative.

JAMA Psychiatry. 2014 Oct;71(10):1183-91. doi: 10.1001/jamapsychiatry.2014.1060.


Presence of ApoE ε4 allele associated with thinner frontal cortex in middle age.

Fennema-Notestine C, Panizzon MS, Thompson WR, Chen CH, Eyler LT, Fischl B, Franz CE, Grant MD, Jak AJ, Jernigan TL, Lyons MJ, Neale MC, Seidman LJ, Tsuang MT, Xian H, Dale AM, Kremen WS.

J Alzheimers Dis. 2011;26 Suppl 3:49-60. doi: 10.3233/JAD-2011-0002.


Effects of APOE ε4, age, and HIV on glial metabolites and cognitive deficits.

Chang L, Jiang C, Cunningham E, Buchthal S, Douet V, Andres M, Ernst T.

Neurology. 2014 Jun 17;82(24):2213-22. doi: 10.1212/WNL.0000000000000526. Epub 2014 May 21.


Cerebral metabolite abnormalities in human immunodeficiency virus are associated with cortical and subcortical volumes.

Cohen RA, Harezlak J, Gongvatana A, Buchthal S, Schifitto G, Clark U, Paul R, Taylor M, Thompson P, Tate D, Alger J, Brown M, Zhong J, Campbell T, Singer E, Daar E, McMahon D, Tso Y, Yiannoutsos CT, Navia B; HIV Neuroimaging Consortium.

J Neurovirol. 2010 Nov;16(6):435-44. doi: 10.3109/13550284.2010.520817. Epub 2010 Oct 20.


Genetic variation in apolipoprotein E alters regional gray matter volumes in remitted late-onset depression.

Yuan Y, Zhang Z, Bai F, You J, Yu H, Shi Y, Liu W.

J Affect Disord. 2010 Mar;121(3):273-7. doi: 10.1016/j.jad.2009.07.003. Epub 2009 Jul 31.


Association of apolipoprotein E epsilon2 with white matter disease but not with microbleeds.

Lemmens R, Görner A, Schrooten M, Thijs V.

Stroke. 2007 Apr;38(4):1185-8. Epub 2007 Feb 22.


Association between white matter hyperintensity severity and cognitive impairment according to the presence of the apolipoprotein E (APOE) ε4 allele in the elderly: retrospective analysis of data from the CREDOS study.

Son SJ, Lee KS, Lee Y, Baek JH, Choi SH, Na DL, Seo SW, Oh BH, Hong CH.

J Clin Psychiatry. 2012 Dec;73(12):1555-62. doi: 10.4088/JCP.12m07702. Epub 2012 Oct 30.


Associations between APOE genotype and cerebral small-vessel disease: a longitudinal study.

Luo X, Jiaerken Y, Yu X, Huang P, Qiu T, Jia Y, Li K, Xu X, Shen Z, Guan X, Zhou J, Zhang M, Adni FTADNI.

Oncotarget. 2017 Jul 4;8(27):44477-44489. doi: 10.18632/oncotarget.17724.


Additive effect of LRP8/APOER2 R952Q variant to APOE epsilon2/epsilon3/epsilon4 genotype in modulating apolipoprotein E concentration and the risk of myocardial infarction: a case-control study.

Martinelli N, Olivieri O, Shen GQ, Trabetti E, Pizzolo F, Busti F, Friso S, Bassi A, Li L, Hu Y, Pignatti PF, Corrocher R, Wang QK, Girelli D.

BMC Med Genet. 2009 May 13;10:41. doi: 10.1186/1471-2350-10-41.


Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease.

Premkumar DR, Cohen DL, Hedera P, Friedland RP, Kalaria RN.

Am J Pathol. 1996 Jun;148(6):2083-95.


Decreases in Short Term Memory, IQ, and Altered Brain Metabolic Ratios in Urban Apolipoprotein ε4 Children Exposed to Air Pollution.

Calderón-Garcidueñas L, Mora-Tiscareño A, Franco-Lira M, Zhu H, Lu Z, Solorio E, Torres-Jardón R, D'Angiulli A.

J Alzheimers Dis. 2015;45(3):757-70. doi: 10.3233/JAD-142685.


Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele.

Wishart HA, Saykin AJ, Rabin LA, Santulli RB, Flashman LA, Guerin SJ, Mamourian AC, Belloni DR, Rhodes CH, McAllister TW.

Am J Psychiatry. 2006 Sep;163(9):1603-10.


Apolipoprotein E epsilon4 allele, temporal lobe atrophy, and white matter lesions in late-life dementias.

Barber R, Gholkar A, Scheltens P, Ballard C, McKeith IG, Morris CM, O'Brien JT.

Arch Neurol. 1999 Aug;56(8):961-5.


Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.

Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM.

JAMA. 1997 Oct 22-29;278(16):1349-56.


Brain tissue volumes by APOE genotype and leisure activity-the AGES-Reykjavik Study.

Hafsteinsdottir SH, Eiriksdottir G, Sigurdsson S, Aspelund T, Harris TB, Launer LJ, Gudnason V.

Neurobiol Aging. 2012 Apr;33(4):829.e1-8. doi: 10.1016/j.neurobiolaging.2011.06.028. Epub 2011 Aug 19.


Updated meta-analysis of the role of APOE ε2/ε3/ε4 alleles in frontotemporal lobar degeneration.

Su WH, Shi ZH, Liu SL, Wang XD, Liu S, Ji Y.

Oncotarget. 2017 Jul 4;8(27):43721-43732. doi: 10.18632/oncotarget.17341.

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