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Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon.

Xiao J, Duan Q, Wang Z, Yan W, Sun H, Xue P, Fan X, Zeng X, Chen J, Shao C, Zhu F.

Oncotarget. 2016 Apr 26;7(17):24483-94. doi: 10.18632/oncotarget.8231.


Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells.

Zhu F, Zykova TA, Kang BS, Wang Z, Ebeling MC, Abe Y, Ma WY, Bode AM, Dong Z.

Gastroenterology. 2007 Jul;133(1):219-31. Epub 2007 Apr 25.


The T-LAK Cell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis.

Zykova TA, Zhu F, Wang L, Li H, Bai R, Lim DY, Yao K, Bode AM, Dong Z.

EBioMedicine. 2017 Apr;18:73-82. doi: 10.1016/j.ebiom.2017.04.003. Epub 2017 Apr 6.


PDZ-binding kinase/T-LAK cell-originated protein kinase is a target of the fucoidan from brown alga Fucus evanescens in the prevention of EGF-induced neoplastic cell transformation and colon cancer growth.

Vishchuk OS, Sun H, Wang Z, Ermakova SP, Xiao J, Lu T, Xue P, Zvyagintseva TN, Xiong H, Shao C, Yan W, Duan Q, Zhu F.

Oncotarget. 2016 Apr 5;7(14):18763-73. doi: 10.18632/oncotarget.7708.


Src-mediated cross-talk between farnesoid X and epidermal growth factor receptors inhibits human intestinal cell proliferation and tumorigenesis.

Peng Z, Raufman JP, Xie G.

PLoS One. 2012;7(10):e48461. doi: 10.1371/journal.pone.0048461. Epub 2012 Oct 31.


Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth.

Kim DJ, Li Y, Reddy K, Lee MH, Kim MO, Cho YY, Lee SY, Kim JE, Bode AM, Dong Z.

Cancer Res. 2012 Jun 15;72(12):3060-8. doi: 10.1158/0008-5472.CAN-11-3851. Epub 2012 Apr 20.


Cefradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of T-LAK cell-originated protein kinase.

Fan X, Duan Q, Ke C, Zhang G, Xiao J, Wu D, Zeng X, Chen J, Guo J, Zhou J, Shi F, Zhu F.

Oncotarget. 2016 Apr 26;7(17):24633-45. doi: 10.18632/oncotarget.8260.


Pantoprazole, an FDA-approved proton-pump inhibitor, suppresses colorectal cancer growth by targeting T-cell-originated protein kinase.

Zeng X, Liu L, Zheng M, Sun H, Xiao J, Lu T, Huang G, Chen P, Zhang J, Zhu F, Li H, Duan Q.

Oncotarget. 2016 Apr 19;7(16):22460-73. doi: 10.18632/oncotarget.7984.


Paeonol suppresses solar ultraviolet-induced skin inflammation by targeting T-LAK cell-originated protein kinase.

Xue P, Wang Y, Zeng F, Xiu R, Chen J, Guo J, Yuan P, Liu L, Xiao J, Lu H, Wu D, Pan H, Lu M, Zhu F, Shi F, Duan Q.

Oncotarget. 2017 Apr 18;8(16):27093-27104. doi: 10.18632/oncotarget.15636.


Proton pump inhibitor ilaprazole suppresses cancer growth by targeting T-cell-originated protein kinase.

Zheng M, Luan S, Gao S, Cheng L, Hao B, Li J, Chen Y, Hou X, Chen L, Li H.

Oncotarget. 2017 Jun 13;8(24):39143-39153. doi: 10.18632/oncotarget.16609.


TOPK promotes lung cancer resistance to EGFR tyrosine kinase inhibitors by phosphorylating and activating c-Jun.

Li Y, Yang Z, Li W, Xu S, Wang T, Wang T, Niu M, Zhang S, Jia L, Li S.

Oncotarget. 2016 Feb 9;7(6):6748-64. doi: 10.18632/oncotarget.6826.


Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPK.

Kang NJ, Lee KW, Kim BH, Bode AM, Lee HJ, Heo YS, Boardman L, Limburg P, Lee HJ, Dong Z.

Carcinogenesis. 2011 Jun;32(6):921-8. doi: 10.1093/carcin/bgr022. Epub 2011 Feb 11.


T-LAK cell-originated protein kinase is essential for the proliferation of hepatocellular carcinoma SMMC-7721 cells.

Chen F, Li R, Wang C, Cao L, Wang Y, Yu L.

Cell Biochem Funct. 2013 Dec;31(8):736-42. doi: 10.1002/cbf.2964. Epub 2013 Mar 22.


Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.

Zheng Y, Gierut J, Wang Z, Miao J, Asara JM, Tyner AL.

Oncogene. 2013 Sep 5;32(36):4304-12. doi: 10.1038/onc.2012.427. Epub 2012 Oct 1.


Activation of TOPK by lipopolysaccharide promotes induction of inducible nitric oxide synthase through NF-κB activity in leukemia cells.

Park JH, Jeong YJ, Won HK, Choi SY, Park JH, Oh SM.

Cell Signal. 2014 May;26(5):849-56. doi: 10.1016/j.cellsig.2014.01.004. Epub 2014 Jan 15.


TOPK/PBK promotes cell migration via modulation of the PI3K/PTEN/AKT pathway and is associated with poor prognosis in lung cancer.

Shih MC, Chen JY, Wu YC, Jan YH, Yang BM, Lu PJ, Cheng HC, Huang MS, Yang CJ, Hsiao M, Lai JM.

Oncogene. 2012 May 10;31(19):2389-400. doi: 10.1038/onc.2011.419. Epub 2011 Sep 26.


T-LAK cell-originated protein kinase (TOPK) phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity.

Zykova TA, Zhu F, Vakorina TI, Zhang J, Higgins LA, Urusova DV, Bode AM, Dong Z.

J Biol Chem. 2010 Sep 17;285(38):29138-46. doi: 10.1074/jbc.M110.135905. Epub 2010 Jul 20.


T-LAK Cell-Originated Protein Kinase (TOPK) as a Prognostic Factor and a Potential Therapeutic Target in Ovarian Cancer.

Ikeda Y, Park JH, Miyamoto T, Takamatsu N, Kato T, Iwasa A, Okabe S, Imai Y, Fujiwara K, Nakamura Y, Hasegawa K.

Clin Cancer Res. 2016 Dec 15;22(24):6110-6117. Epub 2016 Jun 22.


The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling.

Asbagh LA, Vazquez I, Vecchione L, Budinska E, De Vriendt V, Baietti MF, Steklov M, Jacobs B, Hoe N, Singh S, Imjeti NS, Zimmermann P, Sablina A, Tejpar S.

Oncotarget. 2014 Oct 30;5(20):10070-83.

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