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Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD.

Pirozzi C, Lama A, Simeoli R, Paciello O, Pagano TB, Mollica MP, Di Guida F, Russo R, Magliocca S, Canani RB, Raso GM, Calignano A, Meli R.

J Nutr Biochem. 2016 Apr;30:108-15. doi: 10.1016/j.jnutbio.2015.12.004. Epub 2016 Jan 4.


Polyphenol-rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction in high-fat diet fed rats.

Lama A, Pirozzi C, Mollica MP, Trinchese G, Di Guida F, Cavaliere G, Calignano A, Mattace Raso G, Berni Canani R, Meli R.

Mol Nutr Food Res. 2017 Mar;61(3). doi: 10.1002/mnfr.201600418. Epub 2016 Dec 20.


Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-α and Nrf2 activation, and NF-κB down-regulation.

Valenzuela R, Illesca P, Echeverría F, Espinosa A, Rincón-Cervera MÁ, Ortiz M, Hernandez-Rodas MC, Valenzuela A, Videla LA.

Food Funct. 2017 Apr 19;8(4):1526-1537. doi: 10.1039/c7fo00090a.


Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice.

Malloy VL, Perrone CE, Mattocks DA, Ables GP, Caliendo NS, Orentreich DS, Orentreich N.

Metabolism. 2013 Nov;62(11):1651-61. doi: 10.1016/j.metabol.2013.06.012. Epub 2013 Aug 5.


Effects of a Lactobacillus paracasei B21060 based synbiotic on steatosis, insulin signaling and toll-like receptor expression in rats fed a high-fat diet.

Raso GM, Simeoli R, Iacono A, Santoro A, Amero P, Paciello O, Russo R, D'Agostino G, Di Costanzo M, Canani RB, Calignano A, Meli R.

J Nutr Biochem. 2014 Jan;25(1):81-90. doi: 10.1016/j.jnutbio.2013.09.006. Epub 2013 Oct 10.


Attenuation of High-Fat Diet-Induced Rat Liver Oxidative Stress and Steatosis by Combined Hydroxytyrosol- (HT-) Eicosapentaenoic Acid Supplementation Mainly Relies on HT.

Echeverría F, Valenzuela R, Bustamante A, Álvarez D, Ortiz M, Soto-Alarcon SA, Muñoz P, Corbari A, Videla LA.

Oxid Med Cell Longev. 2018 Jul 2;2018:5109503. doi: 10.1155/2018/5109503. eCollection 2018.


Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet.

Mattace Raso G, Simeoli R, Russo R, Iacono A, Santoro A, Paciello O, Ferrante MC, Canani RB, Calignano A, Meli R.

PLoS One. 2013 Jul 5;8(7):e68626. doi: 10.1371/journal.pone.0068626. Print 2013.


Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice.

Cao K, Xu J, Zou X, Li Y, Chen C, Zheng A, Li H, Li H, Szeto IM, Shi Y, Long J, Liu J, Feng Z.

Free Radic Biol Med. 2014 Feb;67:396-407. doi: 10.1016/j.freeradbiomed.2013.11.029. Epub 2013 Dec 6.


Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats.

Shen L, Liu Z, Gong J, Zhang L, Wang L, Magdalou J, Chen L, Wang H.

Toxicol Appl Pharmacol. 2014 Jan 15;274(2):263-73. doi: 10.1016/j.taap.2013.11.009. Epub 2013 Nov 22.


Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease rats.

Li S, Liao X, Meng F, Wang Y, Sun Z, Guo F, Li X, Meng M, Li Y, Sun C.

PLoS One. 2014 Jan 29;9(1):e86724. doi: 10.1371/journal.pone.0086724. eCollection 2014. Erratum in: PLoS One. 2014;9(3):e92364.


Oxymatrine ameliorates non-alcoholic fatty liver disease in rats through peroxisome proliferator-activated receptor-α activation.

Shi L, Shi L, Zhang H, Hu Z, Wang C, Zhang D, Song G.

Mol Med Rep. 2013 Aug;8(2):439-45. doi: 10.3892/mmr.2013.1512. Epub 2013 Jun 6.


Effects of sitagliptin on nonalcoholic fatty liver disease in diet-induced obese rats.

Akaslan SB, Degertekin CK, Yilmaz G, Cakir N, Arslan M, Toruner FB.

Metab Syndr Relat Disord. 2013 Aug;11(4):243-50. doi: 10.1089/met.2012.0128. Epub 2013 Apr 1.


Beneficial effects of neomangiferin on high fat diet-induced nonalcoholic fatty liver disease in rats.

Zhou C, Zhou J, Han N, Liu Z, Xiao B, Yin J.

Int Immunopharmacol. 2015 Mar;25(1):218-28. doi: 10.1016/j.intimp.2015.01.027. Epub 2015 Feb 7.


Coffee prevents fatty liver disease induced by a high-fat diet by modulating pathways of the gut-liver axis.

Vitaglione P, Mazzone G, Lembo V, D'Argenio G, Rossi A, Guido M, Savoia M, Salomone F, Mennella I, De Filippis F, Ercolini D, Caporaso N, Morisco F.

J Nutr Sci. 2019 Apr 22;8:e15. doi: 10.1017/jns.2019.10. eCollection 2019.


Adzuki bean ameliorates hepatic lipogenesis and proinflammatory mediator expression in mice fed a high-cholesterol and high-fat diet to induce nonalcoholic fatty liver disease.

Kim S, Hong J, Jeon R, Kim HS.

Nutr Res. 2016 Jan;36(1):90-100. doi: 10.1016/j.nutres.2015.11.002. Epub 2015 Nov 10.


Research on the protection effect of pioglitazone for non-alcoholic fatty liver disease (NAFLD) in rats.

Xu P, Zhang XG, Li YM, Yu CH, Xu L, Xu GY.

J Zhejiang Univ Sci B. 2006 Aug;7(8):627-33.


Therapeutic role of niacin in the prevention and regression of hepatic steatosis in rat model of nonalcoholic fatty liver disease.

Ganji SH, Kukes GD, Lambrecht N, Kashyap ML, Kamanna VS.

Am J Physiol Gastrointest Liver Physiol. 2014 Feb 15;306(4):G320-7. doi: 10.1152/ajpgi.00181.2013. Epub 2013 Dec 19.


Free fatty acids, not triglycerides, are associated with non-alcoholic liver injury progression in high fat diet induced obese rats.

Liu J, Han L, Zhu L, Yu Y.

Lipids Health Dis. 2016 Feb 11;15:27. doi: 10.1186/s12944-016-0194-7.


Preventing non-alcoholic fatty liver disease through Lactobacillus johnsonii BS15 by attenuating inflammation and mitochondrial injury and improving gut environment in obese mice.

Xin J, Zeng D, Wang H, Ni X, Yi D, Pan K, Jing B.

Appl Microbiol Biotechnol. 2014 Aug;98(15):6817-29. doi: 10.1007/s00253-014-5752-1. Epub 2014 May 9.


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