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Mechanisms of vascular dysfunction in acute phase of Trypanosoma cruzi infection in mice.

Silva JF, Capettini LS, da Silva JF, Sales-Junior P, Cruz JS, Cortes SF, Lemos VS.

Vascul Pharmacol. 2016 Jul;82:73-81. doi: 10.1016/j.vph.2016.03.002. Epub 2016 Mar 15.


Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase.

Zhang M, Song P, Xu J, Zou MH.

Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):125-32. doi: 10.1161/ATVBAHA.110.207712. Epub 2010 Oct 14.


Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling.

Mollnau H, Wendt M, Szöcs K, Lassègue B, Schulz E, Oelze M, Li H, Bodenschatz M, August M, Kleschyov AL, Tsilimingas N, Walter U, Förstermann U, Meinertz T, Griendling K, Münzel T.

Circ Res. 2002 Mar 8;90(4):E58-65.


Early life stress in male mice induces superoxide production and endothelial dysfunction in adulthood.

Ho DH, Burch ML, Musall B, Musall JB, Hyndman KA, Pollock JS.

Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1267-74. doi: 10.1152/ajpheart.00016.2016. Epub 2016 Feb 26.


A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice.

Gendron ME, Thorin E.

Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2508-15. Epub 2007 Jul 20.


Aluminum exposure at human dietary levels promotes vascular dysfunction and increases blood pressure in rats: A concerted action of NAD(P)H oxidase and COX-2.

Martinez CS, Piagette JT, Escobar AG, Martín Á, Palacios R, Peçanha FM, Vassallo DV, Exley C, Alonso MJ, Miguel M, Salaices M, Wiggers GA.

Toxicology. 2017 Sep 1;390:10-21. doi: 10.1016/j.tox.2017.08.004. Epub 2017 Aug 19.


Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese Mice.

Xia N, Horke S, Habermeier A, Closs EI, Reifenberg G, Gericke A, Mikhed Y, Münzel T, Daiber A, Förstermann U, Li H.

Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):78-85. doi: 10.1161/ATVBAHA.115.306263. Epub 2015 Nov 19.


Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock.

Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Cuez T, Schunck WH, Manthati VL, Falck JR, Malik KU.

Nitric Oxide. 2013 Sep 1;33:18-41. doi: 10.1016/j.niox.2013.05.001. Epub 2013 May 14.


Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes.

Bitar MS, Wahid S, Mustafa S, Al-Saleh E, Dhaunsi GS, Al-Mulla F.

Eur J Pharmacol. 2005 Mar 21;511(1):53-64.


Western-type diet induces senescence, modifies vascular function in non-senescence mice and triggers adaptive mechanisms in senescent ones.

Onetti Y, Jiménez-Altayó F, Heras M, Vila E, Dantas AP.

Exp Gerontol. 2013 Dec;48(12):1410-9. doi: 10.1016/j.exger.2013.09.004. Epub 2013 Sep 19.


Paradoxical activation of endothelial nitric oxide synthase by NADPH oxidase.

Zhang Q, Malik P, Pandey D, Gupta S, Jagnandan D, Belin de Chantemele E, Banfi B, Marrero MB, Rudic RD, Stepp DW, Fulton DJ.

Arterioscler Thromb Vasc Biol. 2008 Sep;28(9):1627-33. doi: 10.1161/ATVBAHA.108.168278. Epub 2008 Jun 12.


Involvement of nitric oxide (NO) and TNF-alpha in the oxidative stress associated with anemia in experimental Trypanosoma cruzi infection.

Malvezi AD, Cecchini R, de Souza F, Tadokoro CE, Rizzo LV, Pinge-Filho P.

FEMS Immunol Med Microbiol. 2004 May 1;41(1):69-77.


Increased superoxide production and altered nitric oxide-mediated relaxation in the aorta of young but not old male relaxin-deficient mice.

Ng HH, Jelinic M, Parry LJ, Leo CH.

Am J Physiol Heart Circ Physiol. 2015 Jul 15;309(2):H285-96. doi: 10.1152/ajpheart.00786.2014. Epub 2015 May 8.


Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection.

Ashton AW, Mukherjee S, Nagajyothi FN, Huang H, Braunstein VL, Desruisseaux MS, Factor SM, Lopez L, Berman JW, Wittner M, Scherer PE, Capra V, Coffman TM, Serhan CN, Gotlinger K, Wu KK, Weiss LM, Tanowitz HB.

J Exp Med. 2007 Apr 16;204(4):929-40. Epub 2007 Apr 9.


Endothelial dysfunction and compromised eNOS/Akt signaling in the thoracic aorta during the progression of Marfan syndrome.

Chung AW, Au Yeung K, Cortes SF, Sandor GG, Judge DP, Dietz HC, van Breemen C.

Br J Pharmacol. 2007 Apr;150(8):1075-83. Epub 2007 Mar 5.


Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress.

Zhang H, Zhang J, Ungvari Z, Zhang C.

Arterioscler Thromb Vasc Biol. 2009 Aug;29(8):1164-71. doi: 10.1161/ATVBAHA.109.187146. Epub 2009 May 28.


Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity.

Li R, Wang WQ, Zhang H, Yang X, Fan Q, Christopher TA, Lopez BL, Tao L, Goldstein BJ, Gao F, Ma XL.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1703-8. Epub 2007 Sep 25.


Inducible nitric oxide synthase in heart tissue and nitric oxide in serum of Trypanosoma cruzi-infected rhesus monkeys: association with heart injury.

Carvalho CM, Silverio JC, da Silva AA, Pereira IR, Coelho JM, Britto CC, Moreira OC, Marchevsky RS, Xavier SS, Gazzinelli RT, da Glória Bonecini-Almeida M, Lannes-Vieira J.

PLoS Negl Trop Dis. 2012;6(5):e1644. doi: 10.1371/journal.pntd.0001644. Epub 2012 May 8.


Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice.

Ketonen J, Pilvi T, Mervaala E.

Heart Vessels. 2010 May;25(3):254-62. doi: 10.1007/s00380-009-1182-x. Epub 2010 May 29.


Role of ERK1/2 activation and nNOS uncoupling on endothelial dysfunction induced by lysophosphatidylcholine.

Campos-Mota GP, Navia-Pelaez JM, Araujo-Souza JC, Stergiopulos N, Capettini LSA.

Atherosclerosis. 2017 Mar;258:108-118. doi: 10.1016/j.atherosclerosis.2016.11.022. Epub 2016 Nov 18.


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