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High-Throughput Screening Platform for the Discovery of New Immunomodulator Molecules from Natural Product Extract Libraries.

Pérez Del Palacio J, Díaz C, de la Cruz M, Annang F, Martín J, Pérez-Victoria I, González-Menéndez V, de Pedro N, Tormo JR, Algieri F, Rodriguez-Nogales A, Rodríguez-Cabezas ME, Reyes F, Genilloud O, Vicente F, Gálvez J.

J Biomol Screen. 2016 Jul;21(6):567-78. doi: 10.1177/1087057116635517. Epub 2016 Mar 8.


Natural product HTP screening for antibacterial (E.coli 0157:H7) and anti-inflammatory agents in (LPS from E. coli O111:B4) activated macrophages and microglial cells; focus on sepsis.

Mazzio EA, Li N, Bauer D, Mendonca P, Taka E, Darb M, Thomas L, Williams H, Soliman KF.

BMC Complement Altern Med. 2016 Nov 15;16(1):467.


High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.

Annang F, Pérez-Moreno G, García-Hernández R, Cordon-Obras C, Martín J, Tormo JR, Rodríguez L, de Pedro N, Gómez-Pérez V, Valente M, Reyes F, Genilloud O, Vicente F, Castanys S, Ruiz-Pérez LM, Navarro M, Gamarro F, González-Pacanowska D.

J Biomol Screen. 2015 Jan;20(1):82-91. doi: 10.1177/1087057114555846. Epub 2014 Oct 20.


Anti-inflammatory drugs in the treatment of neurodegenerative diseases: current state.

Gilgun-Sherki Y, Melamed E, Offen D.

Curr Pharm Des. 2006;12(27):3509-19. Review.


NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening.

Thornburg CC, Britt JR, Evans JR, Akee RK, Whitt JA, Trinh SK, Harris MJ, Thompson JR, Ewing TL, Shipley SM, Grothaus PG, Newman DJ, Schneider JP, Grkovic T, O'Keefe BR.

ACS Chem Biol. 2018 Sep 21;13(9):2484-2497. doi: 10.1021/acschembio.8b00389. Epub 2018 Jun 13.


Modeling natural anti-inflammatory compounds by molecular topology.

Galvez-Llompart M, Zanni R, García-Domenech R.

Int J Mol Sci. 2011;12(12):9481-503. doi: 10.3390/ijms12129481. Epub 2011 Dec 20.


Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products.

Pérez-Moreno G, Cantizani J, Sánchez-Carrasco P, Ruiz-Pérez LM, Martín J, El Aouad N, Pérez-Victoria I, Tormo JR, González-Menendez V, González I, de Pedro N, Reyes F, Genilloud O, Vicente F, González-Pacanowska D.

PLoS One. 2016 Jan 6;11(1):e0145812. doi: 10.1371/journal.pone.0145812. eCollection 2016.


Recent developments in anti-inflammatory natural products.

Gautam R, Jachak SM.

Med Res Rev. 2009 Sep;29(5):767-820. doi: 10.1002/med.20156. Review.


Antiinflammatory and immunomodulatory activity of an ethanolic extract from the stem bark of Terminalia catappa L. (Combretaceae): In vitro and in vivo evidences.

Abiodun OO, Rodríguez-Nogales A, Algieri F, Gomez-Caravaca AM, Segura-Carretero A, Utrilla MP, Rodriguez-Cabezas ME, Galvez J.

J Ethnopharmacol. 2016 Nov 4;192:309-319. doi: 10.1016/j.jep.2016.07.056. Epub 2016 Jul 21.


Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2- in LPS/IFNγ activated glioma cells.

Mazzio EA, Bauer D, Mendonca P, Taka E, Soliman KF.

J Neuroimmunol. 2017 Jan 15;302:10-19. doi: 10.1016/j.jneuroim.2016.11.012. Epub 2016 Dec 1.


Microscale Adaptation of In Vitro Transcription/Translation for High-Throughput Screening of Natural Product Extract Libraries.

Lowell AN, Santoro N, Swaney SM, McQuade TJ, Schultz PJ, Larsen MJ, Sherman DH.

Chem Biol Drug Des. 2015 Dec;86(6):1331-8. doi: 10.1111/cbdd.12614. Epub 2015 Jul 25.


High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress.

Thorne N, Malik N, Shah S, Zhao J, Class B, Aguisanda F, Southall N, Xia M, McKew JC, Rao M, Zheng W.

Stem Cells Transl Med. 2016 May;5(5):613-27. doi: 10.5966/sctm.2015-0170. Epub 2016 Mar 31.


High impact technologies for natural products screening.

Koehn FE.

Prog Drug Res. 2008;65:175, 177-210. Review.


Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins.

Hassig CA, Zeng FY, Kung P, Kiankarimi M, Kim S, Diaz PW, Zhai D, Welsh K, Morshedian S, Su Y, O'Keefe B, Newman DJ, Rusman Y, Kaur H, Salomon CE, Brown SG, Baire B, Michel AR, Hoye TR, Francis S, Georg GI, Walters MA, Divlianska DB, Roth GP, Wright AE, Reed JC.

J Biomol Screen. 2014 Sep;19(8):1201-11. doi: 10.1177/1087057114536227. Epub 2014 May 27.


Antimicrobial and anti-inflammatory activities of endophytic fungi Talaromyces wortmannii extracts against acne-inducing bacteria.

Pretsch A, Nagl M, Schwendinger K, Kreiseder B, Wiederstein M, Pretsch D, Genov M, Hollaus R, Zinssmeister D, Debbab A, Hundsberger H, Eger A, Proksch P, Wiesner C.

PLoS One. 2014 Jun 2;9(6):e97929. doi: 10.1371/journal.pone.0097929. eCollection 2014.


High-content screening of natural products reveals novel nuclear export inhibitors.

Cautain B, de Pedro N, Murillo Garzón V, Muñoz de Escalona M, González Menéndez V, Tormo JR, Martin J, El Aouad N, Reyes F, Asensio F, Genilloud O, Vicente F, Link W.

J Biomol Screen. 2014 Jan;19(1):57-65. doi: 10.1177/1087057113501389. Epub 2013 Sep 17.


Recent patents in CNS drug discovery: the management of inflammation in the central nervous system.

Nimmo AJ, Vink R.

Recent Pat CNS Drug Discov. 2009 Jun;4(2):86-95. Review.


Marine natural products with anti-inflammatory activity.

Cheung RC, Ng TB, Wong JH, Chen Y, Chan WY.

Appl Microbiol Biotechnol. 2016 Feb;100(4):1645-66. doi: 10.1007/s00253-015-7244-3. Epub 2015 Dec 28. Review.


Anti-inflammatory drugs in the 21st century.

Rainsford KD.

Subcell Biochem. 2007;42:3-27. Review.


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