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Receptor for Advanced Glycation End Products (RAGE) Serves a Protective Role during Klebsiella pneumoniae - Induced Pneumonia.

Achouiti A, de Vos AF, van 't Veer C, Florquin S, Tanck MW, Nawroth PP, Bierhaus A, van der Poll T, van Zoelen MA.

PLoS One. 2016 Jan 29;11(1):e0141000. doi: 10.1371/journal.pone.0141000. eCollection 2016.


Interleukin-1 receptor-associated kinase M-deficient mice demonstrate an improved host defense during Gram-negative pneumonia.

Hoogerwerf JJ, van der Windt GJ, Blok DC, Hoogendijk AJ, De Vos AF, van 't Veer C, Florquin S, Kobayashi KS, Flavell RA, van der Poll T.

Mol Med. 2012 Sep 25;18:1067-75. doi: 10.2119/molmed.2011.00450.


The receptor for advanced glycation end products impairs host defense in pneumococcal pneumonia.

van Zoelen MA, Schouten M, de Vos AF, Florquin S, Meijers JC, Nawroth PP, Bierhaus A, van der Poll T.

J Immunol. 2009 Apr 1;182(7):4349-56. doi: 10.4049/jimmunol.0801199.


Coagulation factor XI improves host defence during murine pneumonia-derived sepsis independent of factor XII activation.

Stroo I, Zeerleder S, Ding C, Luken BM, Roelofs JJTH, de Boer OJ, Meijers JCM, Castellino FJ, van 't Veer C, van der Poll T.

Thromb Haemost. 2017 Jul 26;117(8):1601-1614. doi: 10.1160/TH16-12-0920. Epub 2017 May 11.


Platelet and endothelial cell P-selectin are required for host defense against Klebsiella pneumoniae-induced pneumosepsis.

de Stoppelaar SF, Van't Veer C, Roelofs JJ, Claushuis TA, de Boer OJ, Tanck MW, Hoogendijk AJ, van der Poll T.

J Thromb Haemost. 2015 Jun;13(6):1128-38. doi: 10.1111/jth.12893. Epub 2015 Apr 23.


Klebsiella pneumoniae Siderophores Induce Inflammation, Bacterial Dissemination, and HIF-1α Stabilization during Pneumonia.

Holden VI, Breen P, Houle S, Dozois CM, Bachman MA.

MBio. 2016 Sep 13;7(5). pii: e01397-16. doi: 10.1128/mBio.01397-16.


Osteopontin promotes host defense during Klebsiella pneumoniae-induced pneumonia.

van der Windt GJ, Hoogerwerf JJ, de Vos AF, Florquin S, van der Poll T.

Eur Respir J. 2010 Dec;36(6):1337-45. doi: 10.1183/09031936.00002710. Epub 2010 Apr 8.


Leptin and host defense against Gram-positive and Gram-negative pneumonia in mice.

Wieland CW, Stegenga ME, Florquin S, Fantuzzi G, van der Poll T.

Shock. 2006 Apr;25(4):414-9.


Granzymes A and B Regulate the Local Inflammatory Response during Klebsiella pneumoniae Pneumonia.

García-Laorden MI, Stroo I, Blok DC, Florquin S, Medema JP, de Vos AF, van der Poll T.

J Innate Immun. 2016;8(3):258-68. doi: 10.1159/000443401. Epub 2016 Feb 20.


Limited role of the receptor for advanced glycation end products during Streptococcus pneumoniae bacteremia.

Achouiti A, de Vos AF, de Beer R, Florquin S, van 't Veer C, van der Poll T.

J Innate Immun. 2013;5(6):603-12. doi: 10.1159/000348739. Epub 2013 Jun 15.


Role of triggering receptor expressed on myeloid cells-1/3 in Klebsiella-derived pneumosepsis.

Hommes TJ, Dessing MC, Veer Cv, Florquin S, Colonna M, de Vos AF, van der Poll T.

Am J Respir Cell Mol Biol. 2015 Nov;53(5):647-55. doi: 10.1165/rcmb.2014-0485OC.


Protective role of Mincle in bacterial pneumonia by regulation of neutrophil mediated phagocytosis and extracellular trap formation.

Sharma A, Steichen AL, Jondle CN, Mishra BB, Sharma J.

J Infect Dis. 2014 Jun 1;209(11):1837-46. doi: 10.1093/infdis/jit820. Epub 2013 Dec 17.


The shedding-derived soluble receptor for advanced glycation endproducts sustains inflammation during acute Pseudomonas aeruginosa lung infection.

Antonelli A, Di Maggio S, Rejman J, Sanvito F, Rossi A, Catucci A, Gorzanelli A, Bragonzi A, Bianchi ME, Raucci A.

Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):354-364. doi: 10.1016/j.bbagen.2016.11.040. Epub 2016 Nov 30.


CD44 deficiency is associated with increased bacterial clearance but enhanced lung inflammation during Gram-negative pneumonia.

van der Windt GJ, Florquin S, de Vos AF, van't Veer C, Queiroz KC, Liang J, Jiang D, Noble PW, van der Poll T.

Am J Pathol. 2010 Nov;177(5):2483-94. doi: 10.2353/ajpath.2010.100562. Epub 2010 Sep 23.


Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia.

Mancuso P, Gottschalk A, Phare SM, Peters-Golden M, Lukacs NW, Huffnagle GB.

J Immunol. 2002 Apr 15;168(8):4018-24.


RAGE-Mediated Suppression of Interleukin-10 Results in Enhanced Mortality in a Murine Model of Acinetobacter baumannii Sepsis.

Noto MJ, Becker KW, Boyd KL, Schmidt AM, Skaar EP.

Infect Immun. 2017 Feb 23;85(3). pii: e00954-16. doi: 10.1128/IAI.00954-16. Print 2017 Mar.


Epithelial Myeloid-Differentiation Factor 88 Is Dispensable during Klebsiella Pneumonia.

Anas AA, Claushuis TAM, Mohan RA, Christoffels VM, Aidinis V, Florquin S, Van't Veer C, Hou B, de Vos AF, van der Poll T.

Am J Respir Cell Mol Biol. 2017 May;56(5):648-656. doi: 10.1165/rcmb.2016-0190OC.


Lack of the receptor for advanced glycation end-products attenuates E. coli pneumonia in mice.

Ramsgaard L, Englert JM, Manni ML, Milutinovic PS, Gefter J, Tobolewski J, Crum L, Coudriet GM, Piganelli J, Zamora R, Vodovotz Y, Enghild JJ, Oury TD.

PLoS One. 2011;6(5):e20132. doi: 10.1371/journal.pone.0020132. Epub 2011 May 23.


Receptor for advanced glycation end products facilitates host defense during Escherichia coli-induced abdominal sepsis in mice.

van Zoelen MA, Schmidt AM, Florquin S, Meijers JC, de Beer R, de Vos AF, Nawroth PP, Bierhaus A, van der Poll T.

J Infect Dis. 2009 Sep 1;200(5):765-73. doi: 10.1086/604730. Erratum in: J Infect Dis. 2009 Nov 15;200(10):1629.


Nitric oxide is required for effective innate immunity against Klebsiella pneumoniae.

Tsai WC, Strieter RM, Zisman DA, Wilkowski JM, Bucknell KA, Chen GH, Standiford TJ.

Infect Immun. 1997 May;65(5):1870-5.

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