Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 121

1.

Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21.

Dunshee DR, Bainbridge TW, Kljavin NM, Zavala-Solorio J, Schroeder AC, Chan R, Corpuz R, Wong M, Zhou W, Deshmukh G, Ly J, Sutherlin DP, Ernst JA, Sonoda J.

J Biol Chem. 2016 Mar 11;291(11):5986-96. doi: 10.1074/jbc.M115.710582. Epub 2016 Jan 21.

2.

FAP finds FGF21 easy to digest.

Gillum MP, Potthoff MJ.

Biochem J. 2016 May 1;473(9):1125-7. doi: 10.1042/BCJ20160004.

PMID:
27118870
3.

Human FGF-21 Is a Substrate of Fibroblast Activation Protein.

Coppage AL, Heard KR, DiMare MT, Liu Y, Wu W, Lai JH, Bachovchin WW.

PLoS One. 2016 Mar 10;11(3):e0151269. doi: 10.1371/journal.pone.0151269. eCollection 2016.

4.

Increased expression of fibroblast activation protein-alpha in keloid fibroblasts: implications for development of a novel treatment option.

Dienus K, Bayat A, Gilmore BF, Seifert O.

Arch Dermatol Res. 2010 Dec;302(10):725-31. doi: 10.1007/s00403-010-1084-x. Epub 2010 Sep 26.

PMID:
20872224
5.

A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys.

Stanislaus S, Hecht R, Yie J, Hager T, Hall M, Spahr C, Wang W, Weiszmann J, Li Y, Deng L, Winters D, Smith S, Zhou L, Li Y, Véniant MM, Xu J.

Endocrinology. 2017 May 1;158(5):1314-1327. doi: 10.1210/en.2016-1917.

PMID:
28324011
6.

Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice.

Fan MH, Zhu Q, Li HH, Ra HJ, Majumdar S, Gulick DL, Jerome JA, Madsen DH, Christofidou-Solomidou M, Speicher DW, Bachovchin WW, Feghali-Bostwick C, Puré E.

J Biol Chem. 2016 Apr 8;291(15):8070-89. doi: 10.1074/jbc.M115.701433. Epub 2015 Dec 9.

7.

A specific, transmembrane interface regulates fibroblast activation protein (FAP) homodimerization, trafficking and exopeptidase activity.

Wonganu B, Berger BW.

Biochim Biophys Acta. 2016 Aug;1858(8):1876-82. doi: 10.1016/j.bbamem.2016.05.001. Epub 2016 May 4.

8.

Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions.

Huang Y, Simms AE, Mazur A, Wang S, León NR, Jones B, Aziz N, Kelly T.

Clin Exp Metastasis. 2011 Aug;28(6):567-79. doi: 10.1007/s10585-011-9392-x. Epub 2011 May 22.

PMID:
21604185
9.

Circulating FGF21 proteolytic processing mediated by fibroblast activation protein.

Zhen EY, Jin Z, Ackermann BL, Thomas MK, Gutierrez JA.

Biochem J. 2016 Mar 1;473(5):605-14. doi: 10.1042/BJ20151085. Epub 2015 Dec 3.

10.

Iterative design of emetine-based prodrug targeting fibroblast activation protein (FAP) and dipeptidyl peptidase IV DPPIV using a tandem enzymatic activation strategy.

Akinboye ES, Brennen WN, Rosen DM, Bakare O, Denmeade SR.

Prostate. 2016 Jun;76(8):703-14. doi: 10.1002/pros.23162. Epub 2016 Feb 2.

PMID:
26835873
11.

Targeting the cancer stroma with a fibroblast activation protein-activated promelittin protoxin.

LeBeau AM, Brennen WN, Aggarwal S, Denmeade SR.

Mol Cancer Ther. 2009 May;8(5):1378-86. doi: 10.1158/1535-7163.MCT-08-1170. Epub 2009 May 5.

12.

Coupled expression of dipeptidyl peptidase-IV and fibroblast activation protein-α in transformed astrocytic cells.

Balaziova E, Busek P, Stremenova J, Sromova L, Krepela E, Lizcova L, Sedo A.

Mol Cell Biochem. 2011 Aug;354(1-2):283-9. doi: 10.1007/s11010-011-0828-z. Epub 2011 Apr 28.

PMID:
21526345
13.

Fibroblast activation protein regulates tumor-associated fibroblasts and epithelial ovarian cancer cells.

Lai D, Ma L, Wang F.

Int J Oncol. 2012 Aug;41(2):541-50. doi: 10.3892/ijo.2012.1475. Epub 2012 May 14.

PMID:
22614695
14.

Mechanistic investigation of the preclinical pharmacokinetics and interspecies scaling of PF-05231023, a fibroblast growth factor 21-antibody protein conjugate.

Giragossian C, Vage C, Li J, Pelletier K, Piché-Nicholas N, Rajadhyaksha M, Liras J, Logan A, Calle RA, Weng Y.

Drug Metab Dispos. 2015 Jun;43(6):803-11. doi: 10.1124/dmd.114.061713. Epub 2015 Mar 24.

15.

A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation.

Osborne B, Yao TW, Wang XM, Chen Y, Kotan LD, Nadvi NA, Herdem M, McCaughan GW, Allen JD, Yu DM, Topaloglu AK, Gorrell MD.

Biochim Biophys Acta. 2014 Jul;1844(7):1248-59. doi: 10.1016/j.bbapap.2014.03.015. Epub 2014 Apr 6.

PMID:
24717288
16.

Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers.

Scanlan MJ, Raj BK, Calvo B, Garin-Chesa P, Sanz-Moncasi MP, Healey JH, Old LJ, Rettig WJ.

Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5657-61.

17.

Fibroblast activation protein is dispensable in the anti-influenza immune response in mice.

Tan SY, Chowdhury S, Polak N, Gorrell MD, Weninger W.

PLoS One. 2017 Feb 3;12(2):e0171194. doi: 10.1371/journal.pone.0171194. eCollection 2017.

18.

Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis.

Jiang S, Yan C, Fang QC, Shao ML, Zhang YL, Liu Y, Deng YP, Shan B, Liu JQ, Li HT, Yang L, Zhou J, Dai Z, Liu Y, Jia WP.

J Biol Chem. 2014 Oct 24;289(43):29751-65. doi: 10.1074/jbc.M114.565960. Epub 2014 Aug 28.

19.

FGF21-receptor agonists: an emerging therapeutic class for obesity-related diseases.

Sonoda J, Chen MZ, Baruch A.

Horm Mol Biol Clin Investig. 2017 May 19;30(2). pii: /j/hmbci.2017.30.issue-2/hmbci-2017-0002/hmbci-2017-0002.xml. doi: 10.1515/hmbci-2017-0002. Review.

PMID:
28525362
20.

Identification of inhibitory scFv antibodies targeting fibroblast activation protein utilizing phage display functional screens.

Zhang J, Valianou M, Simmons H, Robinson MK, Lee HO, Mullins SR, Marasco WA, Adams GP, Weiner LM, Cheng JD.

FASEB J. 2013 Feb;27(2):581-9. doi: 10.1096/fj.12-210377. Epub 2012 Oct 26.

Supplemental Content

Support Center