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Items: 1 to 20 of 99


Efficient extravasation of tumor-repopulating cells depends on cell deformability.

Chen J, Zhou W, Jia Q, Chen J, Zhang S, Yao W, Wei F, Zhang Y, Yang F, Huang W, Zhang Y, Zhang H, Zhang Y, Huang B, Zhang Z, Jia H, Wang N.

Sci Rep. 2016 Jan 20;6:19304. doi: 10.1038/srep19304.


Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression.

Tan Y, Tajik A, Chen J, Jia Q, Chowdhury F, Wang L, Chen J, Zhang S, Hong Y, Yi H, Wu DC, Zhang Y, Wei F, Poh YC, Seong J, Singh R, Lin LJ, Doğanay S, Li Y, Jia H, Ha T, Wang Y, Huang B, Wang N.

Nat Commun. 2014 Aug 6;5:4619. doi: 10.1038/ncomms5619.


Soft matrices downregulate FAK activity to promote growth of tumor-repopulating cells.

Tan Y, Wood AR, Jia Q, Zhou W, Luo J, Yang F, Chen J, Chen J, Sun J, Seong J, Tajik A, Singh R, Wang N.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):456-462. doi: 10.1016/j.bbrc.2016.12.122. Epub 2016 Dec 20.


Low Levels of Sox2 are required for Melanoma Tumor-Repopulating Cell Dormancy.

Jia Q, Yang F, Huang W, Zhang Y, Bao B, Li K, Wei F, Zhang C, Jia H.

Theranostics. 2019 Jan 1;9(2):424-435. doi: 10.7150/thno.29698. eCollection 2019.


Downregulation of YAP-dependent Nupr1 promotes tumor-repopulating cell growth in soft matrices.

Jia Q, Zhou W, Yao W, Yang F, Zhang S, Singh R, Chen J, Chen JJ, Zhang Y, Wei F, Zhang Y, Jia H, Wang N.

Oncogenesis. 2016 Apr 18;5:e220. doi: 10.1038/oncsis.2016.29.


EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer.

Singh S, Trevino J, Bora-Singhal N, Coppola D, Haura E, Altiok S, Chellappan SP.

Mol Cancer. 2012 Sep 25;11:73. doi: 10.1186/1476-4598-11-73.


Cdc42-dependent modulation of rigidity sensing and cell spreading in tumor repopulating cells.

Chowdhury F, Doğanay S, Leslie BJ, Singh R, Amar K, Talluri B, Park S, Wang N, Ha T.

Biochem Biophys Res Commun. 2018 Jun 7;500(3):557-563. doi: 10.1016/j.bbrc.2018.04.085. Epub 2018 Apr 23.


Upregulation of cytosolic phosphoenolpyruvate carboxykinase is a critical metabolic event in melanoma cells that repopulate tumors.

Li Y, Luo S, Ma R, Liu J, Xu P, Zhang H, Tang K, Ma J, Zhang Y, Liang X, Sun Y, Ji T, Wang N, Huang B.

Cancer Res. 2015 Apr 1;75(7):1191-6. doi: 10.1158/0008-5472.CAN-14-2615. Epub 2015 Feb 24.


Evaluating human cancer cell metastasis in zebrafish.

Teng Y, Xie X, Walker S, White DT, Mumm JS, Cowell JK.

BMC Cancer. 2013 Oct 4;13:453. doi: 10.1186/1471-2407-13-453.


Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer.

Xiang R, Liao D, Cheng T, Zhou H, Shi Q, Chuang TS, Markowitz D, Reisfeld RA, Luo Y.

Br J Cancer. 2011 Apr 26;104(9):1410-7. doi: 10.1038/bjc.2011.94. Epub 2011 Apr 5. Erratum in: Br J Cancer. 2011 Jun 7;104(12):1931.


The dark side of SOX2: cancer - a comprehensive overview.

Wuebben EL, Rizzino A.

Oncotarget. 2017 Jul 4;8(27):44917-44943. doi: 10.18632/oncotarget.16570. Review.


YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells.

Bora-Singhal N, Nguyen J, Schaal C, Perumal D, Singh S, Coppola D, Chellappan S.

Stem Cells. 2015 Jun;33(6):1705-18. doi: 10.1002/stem.1993.


Development of a Sox2 reporter system modeling cellular heterogeneity in glioma.

Stoltz K, Sinyuk M, Hale JS, Wu Q, Otvos B, Walker K, Vasanji A, Rich JN, Hjelmeland AB, Lathia JD.

Neuro Oncol. 2015 Mar;17(3):361-71. doi: 10.1093/neuonc/nou320. Epub 2014 Nov 21.


SOX2 plays a critical role in EGFR-mediated self-renewal of human prostate cancer stem-like cells.

Rybak AP, Tang D.

Cell Signal. 2013 Dec;25(12):2734-42. doi: 10.1016/j.cellsig.2013.08.041. Epub 2013 Sep 13.


SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma.

Boumahdi S, Driessens G, Lapouge G, Rorive S, Nassar D, Le Mercier M, Delatte B, Caauwe A, Lenglez S, Nkusi E, Brohée S, Salmon I, Dubois C, del Marmol V, Fuks F, Beck B, Blanpain C.

Nature. 2014 Jul 10;511(7508):246-50. doi: 10.1038/nature13305. Epub 2014 Jun 8.


VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2.

Zhao D, Pan C, Sun J, Gilbert C, Drews-Elger K, Azzam DJ, Picon-Ruiz M, Kim M, Ullmer W, El-Ashry D, Creighton CJ, Slingerland JM.

Oncogene. 2015 Jun 11;34(24):3107-19. doi: 10.1038/onc.2014.257. Epub 2014 Aug 25.


Regulation of colorectal carcinoma stemness, growth, and metastasis by an miR-200c-Sox2-negative feedback loop mechanism.

Lu YX, Yuan L, Xue XL, Zhou M, Liu Y, Zhang C, Li JP, Zheng L, Hong M, Li XN.

Clin Cancer Res. 2014 May 15;20(10):2631-42. doi: 10.1158/1078-0432.CCR-13-2348. Epub 2014 Mar 21.


Cervical cancer cells with positive Sox2 expression exhibit the properties of cancer stem cells.

Liu XF, Yang WT, Xu R, Liu JT, Zheng PS.

PLoS One. 2014 Jan 28;9(1):e87092. doi: 10.1371/journal.pone.0087092. eCollection 2014.


SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells.

Santini R, Pietrobono S, Pandolfi S, Montagnani V, D'Amico M, Penachioni JY, Vinci MC, Borgognoni L, Stecca B.

Oncogene. 2014 Sep 18;33(38):4697-708. doi: 10.1038/onc.2014.71. Epub 2014 Mar 31.

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