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Items: 1 to 20 of 80

1.

Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants.

Rueda P, Harley E, Lu Y, Stewart GD, Fabb S, Diepenhorst N, Cremers B, Rouillon MH, Wehrle I, Geant A, Lamarche G, Leach K, Charman WN, Christopoulos A, Summers RJ, Sexton PM, Langmead CJ.

PLoS One. 2016 Jan 19;11(1):e0146846. doi: 10.1371/journal.pone.0146846. eCollection 2016.

2.

GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo.

Pi M, Wu Y, Quarles LD.

J Bone Miner Res. 2011 Jul;26(7):1680-3. doi: 10.1002/jbmr.390.

3.

Evidence for Osteocalcin Binding and Activation of GPRC6A in β-Cells.

Pi M, Kapoor K, Ye R, Nishimoto SK, Smith JC, Baudry J, Quarles LD.

Endocrinology. 2016 May;157(5):1866-80. doi: 10.1210/en.2015-2010. Epub 2016 Mar 23.

4.

Multiligand specificity and wide tissue expression of GPRC6A reveals new endocrine networks.

Pi M, Quarles LD.

Endocrinology. 2012 May;153(5):2062-9. doi: 10.1210/en.2011-2117. Epub 2012 Feb 28. Review.

5.

GPRC6A: Jack of all metabolism (or master of none).

Pi M, Nishimoto SK, Quarles LD.

Mol Metab. 2016 Dec 21;6(2):185-193. doi: 10.1016/j.molmet.2016.12.006. eCollection 2017 Feb. Review.

6.

Delineation of the GPRC6A receptor signaling pathways using a mammalian cell line stably expressing the receptor.

Jacobsen SE, Nørskov-Lauritsen L, Thomsen AR, Smajilovic S, Wellendorph P, Larsson NH, Lehmann A, Bhatia VK, Bräuner-Osborne H.

J Pharmacol Exp Ther. 2013 Nov;347(2):298-309. doi: 10.1124/jpet.113.206276. Epub 2013 Sep 5.

PMID:
24008333
7.

Robust GLP-1 secretion by basic L-amino acids does not require the GPRC6A receptor.

Clemmensen C, Jørgensen CV, Smajilovic S, Bräuner-Osborne H.

Diabetes Obes Metab. 2017 Apr;19(4):599-603. doi: 10.1111/dom.12845. Epub 2017 Jan 19.

PMID:
27943578
8.

GPRC6A mediates the effects of L-arginine on insulin secretion in mouse pancreatic islets.

Pi M, Wu Y, Lenchik NI, Gerling I, Quarles LD.

Endocrinology. 2012 Oct;153(10):4608-15. Epub 2012 Aug 7.

9.

Identification of a novel extracellular cation-sensing G-protein-coupled receptor.

Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD.

J Biol Chem. 2005 Dec 2;280(48):40201-9. Epub 2005 Sep 30.

10.

The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells.

Oya M, Kitaguchi T, Pais R, Reimann F, Gribble F, Tsuboi T.

J Biol Chem. 2013 Feb 15;288(7):4513-21. doi: 10.1074/jbc.M112.402677. Epub 2012 Dec 26.

11.

Pharmacological characterization of mouse GPRC6A, an L-alpha-amino-acid receptor modulated by divalent cations.

Christiansen B, Hansen KB, Wellendorph P, Bräuner-Osborne H.

Br J Pharmacol. 2007 Mar;150(6):798-807. Epub 2007 Jan 22.

12.

Structural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral Tissues.

Pi M, Kapoor K, Wu Y, Ye R, Senogles SE, Nishimoto SK, Hwang DJ, Miller DD, Narayanan R, Smith JC, Baudry J, Quarles LD.

Mol Endocrinol. 2015 Dec;29(12):1759-73. doi: 10.1210/me.2015-1161. Epub 2015 Oct 6.

13.

Osteocalcin induces release of glucagon-like peptide-1 and thereby stimulates insulin secretion in mice.

Mizokami A, Yasutake Y, Gao J, Matsuda M, Takahashi I, Takeuchi H, Hirata M.

PLoS One. 2013;8(2):e57375. doi: 10.1371/journal.pone.0057375. Epub 2013 Feb 20.

14.

GPCR6A Is a Molecular Target for the Natural Products Gallate and EGCG in Green Tea.

Pi M, Kapoor K, Ye R, Smith JC, Baudry J, Quarles LD.

Mol Nutr Food Res. 2018 Apr;62(8):e1700770. doi: 10.1002/mnfr.201700770. Epub 2018 Apr 14.

15.

GPRC6A regulates prostate cancer progression.

Pi M, Quarles LD.

Prostate. 2012 Mar;72(4):399-409. doi: 10.1002/pros.21442. Epub 2011 Jun 16.

16.

The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function.

Clemmensen C, Smajilovic S, Wellendorph P, Bräuner-Osborne H.

Br J Pharmacol. 2014 Mar;171(5):1129-41. doi: 10.1111/bph.12365. Review.

17.

CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model.

Ye R, Pi M, Cox JV, Nishimoto SK, Quarles LD.

J Exp Clin Cancer Res. 2017 Jun 28;36(1):90. doi: 10.1186/s13046-017-0561-x.

18.

Impaired osteoblast function in GPRC6A null mice.

Pi M, Zhang L, Lei SF, Huang MZ, Zhu W, Zhang J, Shen H, Deng HW, Quarles LD.

J Bone Miner Res. 2010 May;25(5):1092-102. doi: 10.1359/jbmr.091037.

19.

Osteocalcin and Sex Hormone Binding Globulin Compete on a Specific Binding Site of GPRC6A.

De Toni L, Guidolin D, De Filippis V, Tescari S, Strapazzon G, Santa Rocca M, Ferlin A, Plebani M, Foresta C.

Endocrinology. 2016 Nov;157(11):4473-4486. Epub 2016 Sep 27.

PMID:
27673554
20.

Oral administration of osteocalcin improves glucose utilization by stimulating glucagon-like peptide-1 secretion.

Mizokami A, Yasutake Y, Higashi S, Kawakubo-Yasukochi T, Chishaki S, Takahashi I, Takeuchi H, Hirata M.

Bone. 2014 Dec;69:68-79. doi: 10.1016/j.bone.2014.09.006. Epub 2014 Sep 16.

PMID:
25230237

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