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Metallothionein's role in PCB126 induced hepatotoxicity and hepatic micronutrient disruption.

Klaren WD, Flor S, Gibson-Corley KN, Ludewig G, Robertson LW.

Toxicol Rep. 2016;3:21-28.


Progression of micronutrient alteration and hepatotoxicity following acute PCB126 exposure.

Klaren WD, Gadupudi GS, Wels B, Simmons DL, Olivier AK, Robertson LW.

Toxicology. 2015 Dec 2;338:1-7. doi: 10.1016/j.tox.2015.09.004. Epub 2015 Sep 26.


Assessment of the Mitigative Capacity of Dietary Zinc on PCB126 Hepatotoxicity and the Contribution of Zinc to Toxicity.

Klaren WD, Gibson-Corley KN, Wels B, Simmons DL, McCormick ML, Spitz DR, Robertson LW.

Chem Res Toxicol. 2016 May 16;29(5):851-9. doi: 10.1021/acs.chemrestox.6b00022. Epub 2016 Mar 23.


Does dietary copper supplementation enhance or diminish PCB126 toxicity in the rodent liver?

Lai IK, Klaren WD, Li M, Wels B, Simmons DL, Olivier AK, Haschek WM, Wang K, Ludewig G, Robertson LW.

Chem Res Toxicol. 2013 May 20;26(5):634-44. doi: 10.1021/tx400049s. Epub 2013 Apr 15.


Dietary Manganese Modulates PCB126 Toxicity, Metal Status, and MnSOD in the Rat.

Wang B, Klaren WD, Wels BR, Simmons DL, Olivier AK, Wang K, Robertson LW, Ludewig G.

Toxicol Sci. 2016 Mar;150(1):15-26. doi: 10.1093/toxsci/kfv312. Epub 2015 Dec 10.


PCB126-Induced Disruption in Gluconeogenesis and Fatty Acid Oxidation Precedes Fatty Liver in Male Rats.

Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW.

Toxicol Sci. 2016 Jan;149(1):98-110. doi: 10.1093/toxsci/kfv215. Epub 2015 Sep 22.


Transcriptomics identifies differences between ultrapure non-dioxin-like polychlorinated biphenyls (PCBs) and dioxin-like PCB126 in cultured peripheral blood mononuclear cells.

Wens B, De Boever P, Maes M, Hollanders K, Schoeters G.

Toxicology. 2011 Sep 5;287(1-3):113-23. doi: 10.1016/j.tox.2011.06.004. Epub 2011 Jun 14.


Augmented hepatic injury followed by impaired regeneration in metallothionein-I/II knockout mice after treatment with thioacetamide.

Oliver JR, Jiang S, Cherian MG.

Toxicol Appl Pharmacol. 2006 Feb 1;210(3):190-9. Epub 2005 Jun 24.


Polychlorinated biphenyls (PCBs) inhibit hepcidin expression through an estrogen-like effect associated with disordered systemic iron homeostasis.

Qian Y, Zhang S, Guo W, Ma J, Chen Y, Wang L, Zhao M, Liu S.

Chem Res Toxicol. 2015 Apr 20;28(4):629-40. doi: 10.1021/tx500428r. Epub 2015 Feb 24.


Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL/6 mice.

Kopec AK, Burgoon LD, Ibrahim-Aibo D, Burg AR, Lee AW, Tashiro C, Potter D, Sharratt B, Harkema JR, Rowlands JC, Budinsky RA, Zacharewski TR.

Toxicol Sci. 2010 Nov;118(1):286-97. doi: 10.1093/toxsci/kfq236. Epub 2010 Aug 11.


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