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26769048,30354195,18945968,26848157,23636277,25614284,23659638,22516070,17652512,28083075,21136018,30184110,20089298,24947525,16839345,31766871,24855058,18464157,28148841,24408325,26136249,11487044,32463151,19660789,24233488,31381558,2104522,26355696,32680988,20634381,23559626,19561489,26878340,22225793,25769543,26857798,12968031,30700130,33471623,2611327,28882875,22704541,11304482,2760221,19572071,8883269,21976677,35007530,9485373,23667186,26773447,25587039,27605669,19351955,19661487,14521591,32726315,24342536,15059608,7579397,15072993,16254207,15630498,16520742,33267658,28192448,23106920,31511847,8338946,30444568,22197449,12689935,28592700,22187047,9459343,27992950,20589321,26613657,23925504,29472230,35352494,28760385,29724819,20727068,10781579,15923400,20589316,27207414,3362867,11434684,27764259,7627702,26848552,22463102,25246564,16357309,870397,21600632,29490257,18419749,27207416,15842358,27813324,12969982,15317813,27634832,8639834,35008781,34813608,29452445,12524437,32102568,9888880,36583671,2297347,6713090,27789475,8343496,18441012,7981188,32369849,29378359,23515926,36696199,9685818,27933406,28095402,2029508,2019570,27085896,24236042,33811105,15522884,19372258,25311576,28124063,8631976,30722019,3537069,27207433,12944405,32276277,9787166,20796202,26725377,33298665,24118982,20223370,25911238,30071479,11342438,28358995,20454680,27339024,8427954,28287584,27672182,11091186,29378352,28957360,7919337,952763,1996320,12167623,11742890,32320291,3487355,33094904,31216638,32920807,350334,23174566,32907366,19541671,30046749,20941387,25116206,28441034,8603018,27559095,23549358,24815347,21527525,33397811,36695400,7489241,26886854,15238823,27126646,28718695,10961575,12351386,27174099,31242030,30808684,33805059,27431334,36774992,22978514,19855083,6453136,10552949,27575053,1191567,6821701,15026422,36037547,3502201,24261634,31519061,32961573,27119646,20439306,34670127,11328287,29654993,32174022,451451,9685817,29223926,8068609,3873069,28032527,34462367,9573017,32375196,19179771,23087356,2346782,29537929,14521588,36239466,24152424,35638310,33920051,28267256,31129447,25163645,6873753,12029092,32653340,36913497,36240297,2944482,2317161,29727017,30842734,35288766,31216587,28251913,26471268,29573326,18983510,21902184,35993516,36598039,25156521,15711719,31055691,28820747,8085234,26384283,350333,15009455,29488682,6117897,8634462,13730014,35452868,19808248,30580561,28756877,29782929,34923393,31754949,28035007,9430333,3487352,20807891,26330411,20439754,33945121,22104070,8303681,32945081,34130349,23026660,18553102,20149924,31237986,25398937,31558144,10880423,28747771,28643538,3017409,238214,34396675,9886908,23348747,35032838,18203955,2344300,27862691,8218859,11020480,32640902,32973556,34066261,30301959,36190110,33462294,10856973,11429331,8148359,7669082,28584295,25303860,25596265,32729516,36940715,35089923,36074709,28981554,30462538,32542960,22550155,27117228,31935292,11604560,28470538,29302840,22674803,22460075,12064570,30980737,29158361,25772112,20405028,21604243,26474813,36813377,6096983,12871398,389757,15280200,28580033,9886907,34768079,25915545,7959365,8948060,27354721,22442348,35284776,26745503,6812674,23634198,22246038,25104801,24951426,3486671,28277064,410226,36936858,31351019,10936860,29211557,27268383,10468229,31655039,36835580,25214193,31863548,8634463,511012,28214822,33537548,8572959,34025450,33122712,24175924,32480168,30692123,8236157,4257236,1471251,20541793,27637310,22837468,28028712,27596064,19465929,7841598,35180657,32510519,23903698,17544031,30674670,28186112,24759142,22194395,16532615,15544706,9335957,15725689,10630991,31827142,34856423,27866916,30898865,3830277,10468228,34553123,23870271,8049446,33709517,27496706,34491991,25908762,7918038,32543068,28802974,14760207,24605991,28053049,33530862,27016582,21304105,11339329,23974300,21727917,28542700,33784516,11137839,24329163,28097231,27006387,5537739,29887539,30462159,29442535,1450175,11460013,3047022,22206421,14081249,34529037,12406151,24951424,12058364,15665395,32343724,35684431,31371073,27894676,27780803,24330648,24501216,30083534,27034318,3865606,7884545,27887727,8172859,31127371,14155476,26842994,24759131,920416,9199819,32932519,12850838,24396387,32426056,36376109,8944926,33134782,26386264,2847155,34476426,31731710,31575344,30365350,28301900,36190991,23200057,11083453,32529909,23447024,27688780,23691951,23642241,8013531,2093400,33974422,31622994,24194822,35401796,24951425,27464497,33600275,34047558,29227293,2054331,33498089,23785270,36442804,34445311,27133256,32949112,24046067,31394759,30048479,25022613,34351069,8794524,6733271,7376130,235595,36636464,23766384,32544388,593991,18204318,34714969,28857774,26969126,32379574,8507885,15170392,10942795,33529943,32112535,8091405,31053712,21221848,7417033,36999030,36137043,12469501,24420855,23200038,26933837,32310682,29399204,1331709,28529666,33860522,20008207,541980,27318053,29395231,28102740,33292285,33868498,36241224,18753650,36547434,26222505,33270819,32929881,28031903,27876270,20441735,36167948,30654498,21437353,3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Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear Flow.

Zilberman-Rudenko J, Itakura A, Wiesenekker CP, Vetter R, Maas C, Gailani D, Tucker EI, Gruber A, Gerdes C, McCarty OJ. Zilberman-Rudenko J, et al. Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):510-7. doi: 10.1161/ATVBAHA.115.307034. Epub 2016 Jan 14. Arterioscler Thromb Vasc Biol. 2016. PMID: 26769048 Free PMC article.

Factor XII Activation Promotes Platelet Consumption in the Presence of Bacterial-Type Long-Chain Polyphosphate In Vitro and In Vivo.

Zilberman-Rudenko J, Reitsma SE, Puy C, Rigg RA, Smith SA, Tucker EI, Silasi R, Merkulova A, McCrae KR, Maas C, Urbanus RT, Gailani D, Morrissey JH, Gruber A, Lupu F, Schmaier AH, McCarty OJT. Zilberman-Rudenko J, et al. Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1748-1760. doi: 10.1161/ATVBAHA.118.311193. Arterioscler Thromb Vasc Biol. 2018. PMID: 30354195 Free PMC article.

Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI.

Tucker EI, Marzec UM, White TC, Hurst S, Rugonyi S, McCarty OJ, Gailani D, Gruber A, Hanson SR. Tucker EI, et al. Blood. 2009 Jan 22;113(4):936-44. doi: 10.1182/blood-2008-06-163675. Epub 2008 Oct 22. Blood. 2009. PMID: 18945968 Free PMC article.

Platelet Control of Fibrin Distribution and Microelasticity in Thrombus Formation Under Flow.

Swieringa F, Baaten CC, Verdoold R, Mastenbroek TG, Rijnveld N, van der Laan KO, Breel EJ, Collins PW, Lancé MD, Henskens YM, Cosemans JM, Heemskerk JW, van der Meijden PE. Swieringa F, et al. Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):692-9. doi: 10.1161/ATVBAHA.115.306537. Epub 2016 Feb 4. Arterioscler Thromb Vasc Biol. 2016. PMID: 26848157

Elevated plasma factor VIII enhances venous thrombus formation in rabbits: contribution of factor XI, von Willebrand factor and tissue factor.

Sugita C, Yamashita A, Matsuura Y, Iwakiri T, Okuyama N, Matsuda S, Matsumoto T, Inoue O, Harada A, Kitazawa T, Hattori K, Shima M, Asada Y. Sugita C, et al. Thromb Haemost. 2013 Jul;110(1):62-75. doi: 10.1160/TH13-01-0069. Epub 2013 May 2. Thromb Haemost. 2013. PMID: 23636277

Fibrin, γ'-fibrinogen, and transclot pressure gradient control hemostatic clot growth during human blood flow over a collagen/tissue factor wound.

Muthard RW, Welsh JD, Brass LF, Diamond SL. Muthard RW, et al. Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):645-54. doi: 10.1161/ATVBAHA.114.305054. Epub 2015 Jan 22. Arterioscler Thromb Vasc Biol. 2015. PMID: 25614284 Free PMC article.

Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates.

Puy C, Tucker EI, Wong ZC, Gailani D, Smith SA, Choi SH, Morrissey JH, Gruber A, McCarty OJ. Puy C, et al. J Thromb Haemost. 2013 Jul;11(7):1341-52. doi: 10.1111/jth.12295. J Thromb Haemost. 2013. PMID: 23659638 Free PMC article.

Thrombus growth and embolism on tissue factor-bearing collagen surfaces under flow: role of thrombin with and without fibrin.

Colace TV, Muthard RW, Diamond SL. Colace TV, et al. Arterioscler Thromb Vasc Biol. 2012 Jun;32(6):1466-76. doi: 10.1161/ATVBAHA.112.249789. Epub 2012 Apr 19. Arterioscler Thromb Vasc Biol. 2012. PMID: 22516070 Free PMC article.

Feedback activation of factor XI by thrombin does not occur in plasma.

Pedicord DL, Seiffert D, Blat Y. Pedicord DL, et al. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12855-60. doi: 10.1073/pnas.0705566104. Epub 2007 Jul 25. Proc Natl Acad Sci U S A. 2007. PMID: 17652512 Free PMC article.

Biorheology of platelet activation in the bloodstream distal to thrombus formation.

Zilberman-Rudenko J, Itakura A, Maddala J, Baker-Groberg SM, Vetter R, Tucker EI, Gruber A, Gerdes C, McCarty OJ. Zilberman-Rudenko J, et al. Cell Mol Bioeng. 2016 Dec;9(4):496-508. doi: 10.1007/s12195-016-0448-5. Epub 2016 May 26. Cell Mol Bioeng. 2016. PMID: 28083075 Free PMC article.

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