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Items: 1 to 20 of 152

1.

Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites.

Dotiwala F, Mulik S, Polidoro RB, Ansara JA, Burleigh BA, Walch M, Gazzinelli RT, Lieberman J.

Nat Med. 2016 Feb;22(2):210-6. doi: 10.1038/nm.4023. Epub 2016 Jan 11.

PMID:
26752517
2.

Granulysin delivered by cytotoxic cells damages endoplasmic reticulum and activates caspase-7 in target cells.

Saini RV, Wilson C, Finn MW, Wang T, Krensky AM, Clayberger C.

J Immunol. 2011 Mar 15;186(6):3497-504. doi: 10.4049/jimmunol.1003409. Epub 2011 Feb 4.

3.

Granulysin expression and the interplay of granulysin and perforin at the maternal-fetal interface.

Veljkovic Vujaklija D, Dominovic M, Gulic T, Mahmutefendic H, Haller H, Saito S, Rukavina D.

J Reprod Immunol. 2013 Apr;97(2):186-96. doi: 10.1016/j.jri.2012.11.003. Epub 2013 Feb 9.

PMID:
23399514
4.

Healthy lifestyles are associated with higher levels of perforin, granulysin and granzymes A/B-expressing cells in peripheral blood lymphocytes.

Li Q, Morimoto K, Nakadai A, Qu T, Matsushima H, Katsumata M, Shimizu T, Inagaki H, Hirata Y, Hirata K, Kawada T, Lu Y, Nakayama K, Krensky AM.

Prev Med. 2007 Feb;44(2):117-23. Epub 2006 Oct 9.

PMID:
17030356
5.

Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes.

Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J.

Cell. 2014 Jun 5;157(6):1309-23. doi: 10.1016/j.cell.2014.03.062. Erratum in: Cell. 2015 May 21;161(5):1229.

7.
8.

Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly decreases the expression of perforin, granzyme A and granulysin in human NK-92CI cell line.

Li Q, Nakadai A, Ishizaki M, Morimoto K, Ueda A, Krensky AM, Kawada T.

Toxicology. 2005 Sep 15;213(1-2):107-16.

PMID:
16002202
9.

Paraflagellar rod protein-specific CD8+ cytotoxic T lymphocytes target Trypanosoma cruzi-infected host cells.

Wrightsman RA, Luhrs KA, Fouts D, Manning JE.

Parasite Immunol. 2002 Aug;24(8):401-12.

10.

A High Yield and Cost-efficient Expression System of Human Granzymes in Mammalian Cells.

Dotiwala F, Fellay I, Filgueira L, Martinvalet D, Lieberman J, Walch M.

J Vis Exp. 2015 Jun 10;(100):e52911. doi: 10.3791/52911.

11.

An antimicrobial activity of cytolytic T cells mediated by granulysin.

Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melián A, Bogdan C, Porcelli SA, Bloom BR, Krensky AM, Modlin RL.

Science. 1998 Oct 2;282(5386):121-5.

12.

Unlocking the secrets of cytotoxic granule proteins.

Smyth MJ, Kelly JM, Sutton VR, Davis JE, Browne KA, Sayers TJ, Trapani JA.

J Leukoc Biol. 2001 Jul;70(1):18-29. Review.

PMID:
11435481
13.

Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis.

Susanto O, Stewart SE, Voskoboinik I, Brasacchio D, Hagn M, Ellis S, Asquith S, Sedelies KA, Bird PI, Waterhouse NJ, Trapani JA.

Cell Death Differ. 2013 Sep;20(9):1183-93. doi: 10.1038/cdd.2013.59. Epub 2013 Jun 7.

14.

New mechanism of organophosphorus pesticide-induced immunotoxicity.

Li Q.

J Nippon Med Sch. 2007 Apr;74(2):92-105. Review.

15.

Trypanosoma cruzi: resistance to the pore forming protein of cytotoxic lymphocytes--perforin.

Bisaggio Rda C, de Castro SL, Barbosa HS, Brandão Cde A, Persechini PM.

Exp Parasitol. 1997 Jun;86(2):144-54.

PMID:
9207744
16.

Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event.

Persic V, Ruzic A, Miletic B, Samsa DT, Rakic M, Raljevic D, Pejcinovic VP, Eminovic S, Zaputovic L, Laskarin G.

Scand J Immunol. 2012 Feb;75(2):231-42. doi: 10.1111/j.1365-3083.2011.02646.x.

17.

Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity.

Sutton VR, Brennan AJ, Ellis S, Danne J, Thia K, Jenkins MR, Voskoboinik I, Pejler G, Johnstone RW, Andrews DM, Trapani JA.

FEBS J. 2016 Mar;283(5):947-61. doi: 10.1111/febs.13649. Epub 2016 Jan 22.

18.
19.

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack.

Lopez JA, Susanto O, Jenkins MR, Lukoyanova N, Sutton VR, Law RH, Johnston A, Bird CH, Bird PI, Whisstock JC, Trapani JA, Saibil HR, Voskoboinik I.

Blood. 2013 Apr 4;121(14):2659-68. doi: 10.1182/blood-2012-07-446146. Epub 2013 Feb 1.

20.

Molecular mechanisms of lymphocyte-mediated cytotoxicity.

Fan Z, Zhang Q.

Cell Mol Immunol. 2005 Aug;2(4):259-64. Review.

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