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Items: 1 to 20 of 110

1.

Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations.

Lorenz S, Barøy T, Sun J, Nome T, Vodák D, Bryne JC, Håkelien AM, Fernandez-Cuesta L, Möhlendick B, Rieder H, Szuhai K, Zaikova O, Ahlquist TC, Thomassen GO, Skotheim RI, Lothe RA, Tarpey PS, Campbell P, Flanagan A, Myklebost O, Meza-Zepeda LA.

Oncotarget. 2016 Feb 2;7(5):5273-88. doi: 10.18632/oncotarget.6567.

2.

Array comparative genomic hybridization in osteosarcoma.

Sadikovic B, Park PC, Selvarajah S, Zielenska M.

Methods Mol Biol. 2013;973:227-47. doi: 10.1007/978-1-62703-281-0_15. Review.

PMID:
23412794
3.

TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome.

Ribi S, Baumhoer D, Lee K, Edison, Teo AS, Madan B, Zhang K, Kohlmann WK, Yao F, Lee WH, Hoi Q, Cai S, Woo XY, Tan P, Jundt G, Smida J, Nathrath M, Sung WK, Schiffman JD, Virshup DM, Hillmer AM.

Oncotarget. 2015 Apr 10;6(10):7727-40.

4.

[The clonal evolution of osteosarcomas].

Baumhoer D.

Pathologe. 2016 Nov;37(Suppl 2):163-168. Review. German.

PMID:
27651058
5.

[Comparative genomic hybridization (CGH) for detecting a heretofore undescribed amplified chromosomal segment in high-grade medullary osteosarcoma].

Brinkschmidt C, Blasius S, Bürger H, Simon R, Diallo R, Battmann A, Winkelmann W, Böcker W, Dockhorn-Dworniczak B.

Verh Dtsch Ges Pathol. 1998;82:184-8. German.

PMID:
10095431
6.

Whole-exome sequencing in osteosarcoma reveals important heterogeneity of genetic alterations.

Bousquet M, Noirot C, Accadbled F, Sales de Gauzy J, Castex MP, Brousset P, Gomez-Brouchet A.

Ann Oncol. 2016 Apr;27(4):738-44. doi: 10.1093/annonc/mdw009. Epub 2016 Jan 19.

PMID:
26787232
7.

Spectral karyotyping identifies recurrent complex rearrangements of chromosomes 8, 17, and 20 in osteosarcomas.

Bayani J, Zielenska M, Pandita A, Al-Romaih K, Karaskova J, Harrison K, Bridge JA, Sorensen P, Thorner P, Squire JA.

Genes Chromosomes Cancer. 2003 Jan;36(1):7-16.

PMID:
12461745
8.

Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma.

Tsuchiya T, Sekine K, Hinohara S, Namiki T, Nobori T, Kaneko Y.

Cancer Genet Cytogenet. 2000 Jul 15;120(2):91-8.

PMID:
10942797
9.

Tp53 deletion in B lineage cells predisposes mice to lymphomas with oncogenic translocations.

Rowh MA, DeMicco A, Horowitz JE, Yin B, Yang-Iott KS, Fusello AM, Hobeika E, Reth M, Bassing CH.

Oncogene. 2011 Nov 24;30(47):4757-64. doi: 10.1038/onc.2011.191. Epub 2011 May 30.

PMID:
21625223
10.

Array comparative genomic hybridization reveals frequent alterations of G1/S checkpoint genes in undifferentiated pleomorphic sarcoma of bone.

Niini T, Lahti L, Michelacci F, Ninomiya S, Hattinger CM, Guled M, Böhling T, Picci P, Serra M, Knuutila S.

Genes Chromosomes Cancer. 2011 May;50(5):291-306. doi: 10.1002/gcc.20851. Epub 2011 Jan 19.

PMID:
21254299
11.

Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma.

Chen X, Bahrami A, Pappo A, Easton J, Dalton J, Hedlund E, Ellison D, Shurtleff S, Wu G, Wei L, Parker M, Rusch M, Nagahawatte P, Wu J, Mao S, Boggs K, Mulder H, Yergeau D, Lu C, Ding L, Edmonson M, Qu C, Wang J, Li Y, Navid F, Daw NC, Mardis ER, Wilson RK, Downing JR, Zhang J, Dyer MA; St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project.

Cell Rep. 2014 Apr 10;7(1):104-12. doi: 10.1016/j.celrep.2014.03.003. Epub 2014 Apr 3.

12.

[Molecular analysis of tumor suppressor genes p16INK4 and TP53 of osteosarcomas in Spanish children].

Patiño García A, Sierrasesúmaga Ariznabarreta L.

An Esp Pediatr. 1997 Nov;47(5):478-82. Spanish.

PMID:
9586287
13.

Microhomology-mediated mechanisms underlie non-recurrent disease-causing microdeletions of the FOXL2 gene or its regulatory domain.

Verdin H, D'haene B, Beysen D, Novikova Y, Menten B, Sante T, Lapunzina P, Nevado J, Carvalho CM, Lupski JR, De Baere E.

PLoS Genet. 2013;9(3):e1003358. doi: 10.1371/journal.pgen.1003358. Epub 2013 Mar 14.

14.

Frequency and structure of p53 rearrangements in human osteosarcoma.

Miller CW, Aslo A, Tsay C, Slamon D, Ishizaki K, Toguchida J, Yamamuro T, Lampkin B, Koeffler HP.

Cancer Res. 1990 Dec 15;50(24):7950-4.

15.

Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas.

Patiño-García A, Piñeiro ES, Díez MZ, Iturriagagoitia LG, Klüssmann FA, Ariznabarreta LS.

J Pediatr Hematol Oncol. 2003 May;25(5):362-7.

PMID:
12759621
16.

Cytogenetic and molecular characterization of plutonium-induced rat osteosarcomas.

Roch-Lefevre S, Daino K, Altmeyer-Morel S, Guilly MN, Chevillard S.

J Radiat Res. 2010;51(3):243-50.

17.

Analysis of oncogene, tumor suppressor gene, and chromosomal alterations in HeLa x osteosarcoma somatic cell hybrids.

Isfort RJ, Cody DB, Lovell GJ, Gioeli D, Weissman BE, Doersen CJ.

Mol Carcinog. 1999 May;25(1):30-41.

PMID:
10331742
18.

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.

Perry JA, Kiezun A, Tonzi P, Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E, Pedamallu CS, Helman E, Taylor-Weiner A, McKenna A, DeLuca DS, Lawrence MS, Ambrogio L, Sougnez C, Sivachenko A, Walensky LD, Wagle N, Mora J, de Torres C, Lavarino C, Dos Santos Aguiar S, Yunes JA, Brandalise SR, Mercado-Celis GE, Melendez-Zajgla J, Cárdenas-Cardós R, Velasco-Hidalgo L, Roberts CW, Garraway LA, Rodriguez-Galindo C, Gabriel SB, Lander ES, Golub TR, Orkin SH, Getz G, Janeway KA.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):E5564-73. doi: 10.1073/pnas.1419260111. Epub 2014 Dec 15.

19.

Alterations of the p53, Rb and MDM2 genes in osteosarcoma.

Miller CW, Aslo A, Won A, Tan M, Lampkin B, Koeffler HP.

J Cancer Res Clin Oncol. 1996;122(9):559-65.

PMID:
8781571
20.

The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability.

Overholtzer M, Rao PH, Favis R, Lu XY, Elowitz MB, Barany F, Ladanyi M, Gorlick R, Levine AJ.

Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11547-52. Epub 2003 Sep 12. Erratum in: Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14511.

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