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26559681,11865092,10916110,29371246,16391331,11979347,28094233,19736473,24652221,26137654,10780318,15115259,16397167,22425007,21367581,28689805,16053010,17342693,14696754,28440964,22507617,9264011,11464650,22084937,16933832,26233336,26171850,29813097,10782453,10323785,15585767,15063399,10337865,10027946,12601627,17284634,11815318,12747601,18412997,11273876,11592445,20670473,11334318,14560345,11431185,16234842,16373648,11169021,11169020,19764044,15040829,15569335,15935452,12560354,30401001,11860891,17436239,12430779,21678004,16682831,32478379,15135689,24797049,24906854,16303969,17043779,22134713,12180000,16820193,12495282,12644913,27515258,26293976,17141597,11177206,11981084,28225483,35951145,17215186,24183735,16190942,18089344,11744804,21878957,14679361,17243563,23818036,21625172,26497154,29182708,16489563,15561486,26142939,20089204,16704755,26774115,11330536,15216546,36662122,12081832,14693836,23698160,11295026,9687553,9194768,29796841,12653261,14608052,28598562,15179108,11257267,10852611,22230384,35904038,10446107,16379339,10081520,34645434,14644226,9583842,19936026,10926884,11060826,30080444,15735067,25297611,12187094,17914182,11981075,10743479,23298970,27187171,19466593,29395581,11523237,29244251,22983814,27486122,22664498,28360116,32019154,15319318,33923969,17332146,10727548,15527064,20216560,9244205,18981340,30255822,14524579,10859289,31932513,23885778,12033523,30245375,11420199,32992197,21508090,16479177,19211833,11589919,26442927,36876682,18803866,9740165,20096138,15895286,34167037,12187113,15883436,26689687,15952099,27453118,16723687,31962182,27783031,36848988,34058062,12077735,25095762,19219535,15528294,37121723,21597397,10919921,19056652,15831132,11555700,22354693,29674265,14581802,30884849,12437493,28938431,31143237,14656250,33486813,32299541,29776960,12092633,10820175,23697869,24498831,12681883,29532755,20065615,28963520,10809239,19768245,29024723,18790817,31055527,19248194,29722849,20926035,16679643,36889645,12399074,26991917,17036383,17396161,15321804,11028163,30264170,37101129,16596805,34019199,19153374,30771856,30999684,23856660,12050947,23247802,22303578,20571015,7931701,15600263,20841390,14597156,15447919,12694331,30207526,34145098,22217364,21966393,16144556,27431367,22069468,19424840,9697819,21772318,30022794,12707400,28381531,24167429,30014716,15755387,10770966,23765945,32432712,30278440,16002796,15765596,12512994,37111114,30451038,28992284,12230295,9550566,18591889,29117460,9952016,10696633,10591669,17622392,32127061,11472746,25391194,12801608,24040787,15354385,27793182,36806868,17449548,31371071,22116453,32325916,14655730,12652107,17028545,30372582,11585023,34836291,10527405,21697534,31127676,19625220,10690947,16407736,11070147,26719836,12220694,19094231,16317120,29644956,35807880,21394321,10590184,34469084,31765437,11961021,15806473,34409847,11466665,22136481,22872164,21358708,32189314,12486865,27379829,10570095,27188895,23873438,14613740,10971789,25758536,26147383,22232016,10208493,21967576,15525878,36308028,32800386,18521531,11470733,18206175,33259482,10229730,36704788,27051654,20433440,19075497,12930236,12370840,23522838,11257557,15912197,21857689,30405296,16960155,11085827,34397449,9472972,30687218,23731042,11902805,33724098,19744961,12535751,8124058,35346016,17024599,11737242,30341095,30217770,31525435,30670531,15466944,16624841,19577940,15469653,28984369,15785306,35337625,12962778,37076800,24705833,28024829,11752047,12127934,12781093,10809271,29395637,30646578,10052494,12198008,28396257,24865596,29529168,29097387,12021579,24711158,11918548,33526724,19630705,18189241,31651110,19484186,25573400,27336853,12429870,32199937,12823643,11889451,33222971,11867886,18787277,10440398,30785218,11169022,17438114,17305530,25016692,12814389,36717385,14630804,24988417,12801809,15630149,33348139,28863787,23716934,31353838,12194912,31864233,14690253,32577886,30813413,10075332,19180309,1444025,11181477,26311810,23105845,22022143,12873546,16612246,34707639,26217629,28149369,29072168,11125576,28910538,33313200,18080853,11981074,33888102,19967264,20374299,29030456,11500187,32234968,22623744,36978223,25644193,10511285,35956194,33865356,11448801,19804640,32161077,12110060,26447155,12793968,36619923,18670064,8642470,11169023,28806886,29679304,20720587,16596546,29384828,11514114,36170884,16407737,31151052,36678310,25994139,27431289,3747349,26929921,34226116,11726432,17896987,35995922,30350398,36264281,24434266,16510043,31915511,11837987,23073272,15354976,34864672,24168846,20814760,23869894,16917400,31401974,18415702,16250860,16361298,20092401,10486705,24122328,14747392,36606759,23716893,23346007,33066869,27462097,12871346,35060542,8261682,37080624,10100295,18447992,33851596,12534325,8770960,32320840,15968341,25221401,24846474,23430668,31015243,34229262,36980981,14559932,20163740,11576930,11123849,22933895,32038964,20975658,19277125,31254573,14989639,9919419,22727498,34680361,32279306,19039474,19560951,33214054,17625006,10681665,3818116,12528764,31389788,36757031,9415345,33809274,15725691,29876016,2257392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The C677T MTHFR genotypes influence the efficacy of B9 and B12 vitamins supplementation to lowering plasma total homocysteine in hemodialysis.

Achour O, Elmtaoua S, Zellama D, Omezzine A, Moussa A, Rejeb J, Boumaiza I, Bouacida L, Rejeb NB, Achour A, Bouslama A. Achour O, et al. J Nephrol. 2016 Oct;29(5):691-8. doi: 10.1007/s40620-015-0235-8. Epub 2015 Nov 11. J Nephrol. 2016. PMID: 26559681 Clinical Trial.

Hyperhomocysteinaemia, folate and vitamin B12 in unsupplemented haemodialysis patients: effect of oral therapy with folic acid and vitamin B12.

Billion S, Tribout B, Cadet E, Queinnec C, Rochette J, Wheatley P, Bataille P. Billion S, et al. Nephrol Dial Transplant. 2002 Mar;17(3):455-61. doi: 10.1093/ndt/17.3.455. Nephrol Dial Transplant. 2002. PMID: 11865092

Hyperhomocysteinemia in hemodialysis patients: effects of 12-month supplementation with hydrosoluble vitamins.

Tremblay R, Bonnardeaux A, Geadah D, Busque L, Lebrun M, Ouimet D, Leblanc M. Tremblay R, et al. Kidney Int. 2000 Aug;58(2):851-8. doi: 10.1046/j.1523-1755.2000.00234.x. Kidney Int. 2000. PMID: 10916110 Free article. Clinical Trial.

MTHFR Gene and Serum Folate Interaction on Serum Homocysteine Lowering: Prospect for Precision Folic Acid Treatment.

Huang X, Qin X, Yang W, Liu L, Jiang C, Zhang X, Jiang S, Bao H, Su H, Li P, He M, Song Y, Zhao M, Yin D, Wang Y, Zhang Y, Li J, Yang R, Wu Y, Hong K, Wu Q, Chen Y, Sun N, Li X, Tang G, Wang B, Cai Y, Hou FF, Huo Y, Wang H, Wang X, Cheng X. Huang X, et al. Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):679-685. doi: 10.1161/ATVBAHA.117.310211. Epub 2018 Jan 25. Arterioscler Thromb Vasc Biol. 2018. PMID: 29371246 Clinical Trial.

Effects of folic acid before and after vitamin B12 on plasma homocysteine concentrations in hemodialysis patients with known MTHFR genotypes.

Pastore A, De Angelis S, Casciani S, Ruggia R, Di Giovamberardino G, Noce A, Splendiani G, Cortese C, Federici G, Dessi' M. Pastore A, et al. Clin Chem. 2006 Jan;52(1):145-8. doi: 10.1373/clinchem.2005.056119. Clin Chem. 2006. PMID: 16391331 Clinical Trial.

Methylenetetrahydrofolate reductase genotype, vitamin B12, and folate influence plasma homocysteine in hemodialysis patients.

Nakamura T, Saionji K, Hiejima Y, Hirayama H, Tago K, Takano H, Tajiri M, Hayashi K, Kawabata M, Funamizu M, Makita Y, Hata A. Nakamura T, et al. Am J Kidney Dis. 2002 May;39(5):1032-9. doi: 10.1053/ajkd.2002.32779. Am J Kidney Dis. 2002. PMID: 11979347

Association between the MTHFR C677T polymorphism, blood folate and vitamin B12 deficiency, and elevated serum total homocysteine in healthy individuals in Yunnan Province, China.

Ni J, Zhang L, Zhou T, Xu WJ, Xue JL, Cao N, Wang X. Ni J, et al. J Chin Med Assoc. 2017 Mar;80(3):147-153. doi: 10.1016/j.jcma.2016.07.005. Epub 2017 Jan 13. J Chin Med Assoc. 2017. PMID: 28094233 Free article.

Efficacy of folate and vitamin B12 in lowering homocysteine concentrations in hemodialysis patients.

Azadibakhsh N, Hosseini RS, Atabak S, Nateghiyan N, Golestan B, Rad AH. Azadibakhsh N, et al. Saudi J Kidney Dis Transpl. 2009 Sep;20(5):779-88. Saudi J Kidney Dis Transpl. 2009. PMID: 19736473 Clinical Trial.

Influence of dialysis techniques and alternate vitamin supplementation on homocysteine levels in patients with known MTHFR genotypes.

Dessì M, Di Giovamberardino G, Pieri M, Noce A, Zenobi R, Di Daniele N, Pastore A. Dessì M, et al. Clin Exp Nephrol. 2015 Feb;19(1):140-5. doi: 10.1007/s10157-014-0961-6. Epub 2014 Mar 21. Clin Exp Nephrol. 2015. PMID: 24652221 Clinical Trial.

Association of Vitamin B12 Deficiency with Homozygosity of the TT MTHFR C677T Genotype, Hyperhomocysteinemia, and Endothelial Cell Dysfunction.

Shiran A, Remer E, Asmer I, Karkabi B, Zittan E, Cassel A, Barak M, Rozenberg O, Karkabi K, Flugelman MY. Shiran A, et al. Isr Med Assoc J. 2015 May;17(5):288-92. Isr Med Assoc J. 2015. PMID: 26137654 Free article.

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