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26540173,26068628,24795159,21956044,26382221,23548259,29860767,30082547,23490648,28748721,25681967,26969090,26894858,27438066,26020808,24975791,26108242,21306819,22658883,26744781,24819320,24931622,24356626,25952317,17577222,27324136,23317510,26455779,26886011,21802830,19064974,26045121,18669461,19745694,23684422,25618828,22237457,27664394,27771126,27484254,26492223,22860625,23511427,24070900,22235142,23956442,20806321,26908232,28143997,26457466,24307427,28254206,28789709,27448573,30268423,24565697,22628612,18618496,20230385,23267717,24559686,23446283,26723100,27487293,25466943,22682982,27119958,20346042,24215209,22095244,23041453,22056973,26687171,16827904,23106948,26215605,28521783,25458371,26658889,27468922,25260080,25688511,21244613,19558553,18692304,24321255,22056247,24485801,26439451,27102405,28199818,26011553,20386528,24321257,21717427,28645482,28532444,30374686,22700990,27754995,22013228,24206640,22766517,18635227,29076108,22460837,27318422,26746623,23579815,27338518,29678472,24613250,23630366,24556802,20089567,31445844,29277808,26707954,30158382,26520429,28720439,21346038,24184025,26652893,28385611,27825515,28392154,27625016,28511146,22173502,28188047,26497860,26685869,30307610,24556040,29774795,32738823,21435216,29055166,26727578,28535693,24247547,27026229,28077238,24675507,28230776,26656362,26408732,29853320,26556569,28549248,31101577,19826129,22033275,26774206,30927174,32727768,26617188,26330533,28122358,31971318,23807171,24474815,29687160,26472104,28220024,24661373,24549799,27981711,25698532,27286871,21953429,29657088,21827392,34583356,31174493,30396966,27541802,30607698,28810837,26163345,27228299,28977627,28089721,26335224,26032863,25502986,23254966,24595903,27638198,33650321,23342925,17619763,31043824,22752573,28423742,26494607,28044472,26769075,25381264,29065412,28113029,21464158,30380460,29198329,30607126,26597814,32958444,25283266,31065836,26763058,22933166,25841722,22886358,31377308,36707357,25476536,24634003,30194193,25503897,27863831,31473122,26313773,30682039,26526582,26899142,33649869,26678908,28404979,24351402,28130612,29940249,27661105,25505255,27198170,28572027,29563634,23300029,31630333,26372698,33212499,31000484,24365125,30417707,24127298,23462722,27395374,25538263,27553579,27008916,24302609,30887420,24107823,25688514,28683470,28271073,27727447,27003551,23254792,28667354,30194186,29737510,25267763,30279115,28056941,20502715,21882181,27473522,33863648,28436250,28413127,25386811,22877847,23140823,28216276,24685884,23262811,28801802,23179639,30341028,28378918,26031304,25688517,24337833,23696129,23138000,30459123,24807769,25714313,22228446,26969091,30680522,24398141,29268716,21174224,29084643,30917871,32321460,23972707,26449266,29607820,27817860,32037304,24987183,21490127,26320662,24841777,31342557,27601362,28040423,27777776,32889831,21829041,29437040,25586958,28485356,28545581,27537400,29641297,28143610,28485355,31416753,26694813,22733795,29503245,27040380,26830973,35125401,26625878,31640912,31753738,26210683,31727510,27174049,25577718,20171141,23971369,24414551,25688516,26708631,27178184,27165064,31926879,28732453,30128854,25291078,29848258,21799472,26676614,28276433,24217676,32972885,31786162,28073101,28044054,28213730,31594707,28945839,29311252,24852879,29570259,21386843,34726480,19364969,32164576,25424248,36014894,16729911,26959411,36328934,26300443,22004675,31562048,22020210,22327313,31595385,33512910,26832420,28676023,20952123,25987339,28552572,30301699,24556857,29041991,28882737,27467136,25956420,28205224,24755461,27342991,33688021,32693975,26400730,27485537,34559626,28414866,30421088,27142582,31388933,23962746,24839711,32694008,25076258,22139625,31229459,28653574,21812499,22573349,35687336,23636006,31063191,22968651,30507262,30785902,24598448,26997520,26825962,30572736,33135866,28506529,30111978,24906441,24169357,33674246,28056412,25724518,32162798,26654225,26832350,33479762,10637252,30194179,20956731,23646100,23686671,26507837,29264944,26683674,27690664,23999581,29935840,30529389,30624766,28932952,27407122,29714652,27515221,34397846,26758665,23567227,25267752,25267750,34475048,30711987,34472040,26087607,24093097,25267749,24687838,24691425,26306562,26614032,16185167,23312463,28082434,23436165,29803346,24548864,29858123,30131292,28448047,19430003,33388280,26906039,24766821,34191191,33491495,20089566,22752571,18774306,25275248,21711062,27462141,28196874,30385613,33290313,23708063,30428867,32703342,24731995,28624136,31400935,31010693,33812180,27613167,31762165,24140182,27923360,25115744,24631407,28224821,30194077,35693709,28167571,34791942,31646819,34295728,28188447,30374764,33229506,30772204,29848570,12448656,25701692,10561320,26305535,33730725,23925998,21827394,21051659,25922090,29281478,34158246,23404195,30831663,25956488,29172746,27404275,30858035,28392165,28183256,28920717,35674770,29428404,17366861,23995527,30007862,32591963,34176762,20145619,17553205,34741719,26001179,33183198,30173085,26068629,33271325,24061041,28723377,23682094,22545314,24135148,23457926,30348724,16034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Risk factors and model for predicting toxicity-related treatment discontinuation in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy: Results from the International Metastatic Renal Cell Carcinoma Database Consortium.

Kaymakcalan MD, Xie W, Albiges L, North SA, Kollmannsberger CK, Smoragiewicz M, Kroeger N, Wells JC, Rha SY, Lee JL, McKay RR, Fay AP, De Velasco G, Heng DY, Choueiri TK. Kaymakcalan MD, et al. Cancer. 2016 Feb 1;122(3):411-9. doi: 10.1002/cncr.29773. Epub 2015 Nov 5. Cancer. 2016. PMID: 26540173 Free article.

Prolonging survival in metastatic renal cell carcinoma patients treated with targeted anticancer agents: a single-center experience of treatment strategy modifications.

Ninomiya N, Tamada S, Kato M, Yamasaki T, Iguchi T, Nakatani T. Ninomiya N, et al. Can J Urol. 2015 Jun;22(3):7798-804. Can J Urol. 2015. PMID: 26068628

Sequential targeted therapy after pazopanib therapy in patients with metastatic renal cell cancer: efficacy and toxicity.

Bellmunt J, Pons F, Foreshew A, Fay AP, Powles T, Porta C, Bracarda S, Lampron ME, Cerbone L, Sternberg CN, Hutson TE, Choueiri TK. Bellmunt J, et al. Clin Genitourin Cancer. 2014 Aug;12(4):262-9. doi: 10.1016/j.clgc.2014.03.002. Epub 2014 Mar 14. Clin Genitourin Cancer. 2014. PMID: 24795159

Utilizing pre-therapy clinical schema and initial CT changes to predict progression-free survival in patients with metastatic renal cell carcinoma on VEGF-targeted therapy: a preliminary analysis.

Smith AD, Shah SN, Rini BI, Lieber ML, Remer EM. Smith AD, et al. Urol Oncol. 2013 Oct;31(7):1283-91. doi: 10.1016/j.urolonc.2011.08.010. Epub 2011 Sep 29. Urol Oncol. 2013. PMID: 21956044

Absence of Significant Correlation of Adverse Events Between First- and Second-Line Tyrosine Kinase Inhibitors in Patients With Metastatic Renal Cell Carcinoma.

Miyake H, Imai S, Harada K, Fujisawa M. Miyake H, et al. Clin Genitourin Cancer. 2016 Feb;14(1):e19-24. doi: 10.1016/j.clgc.2015.08.002. Epub 2015 Aug 15. Clin Genitourin Cancer. 2016. PMID: 26382221

Comparative efficacy of sunitinib versus sorafenib as first-line treatment for patients with metastatic renal cell carcinoma.

Park SJ, Lee JL, Park I, Park K, Ahn Y, Ahn JH, Lee DH, Ahn S, Song C, Hong JH, Kim CS, Ahn H. Park SJ, et al. Chemotherapy. 2012;58(6):468-74. doi: 10.1159/000346484. Epub 2013 Mar 20. Chemotherapy. 2012. PMID: 23548259 Free article.

[Comparison of efficacy between sorafenib and sunitinib as first-line therapy for metastatic renal cell carcinoma and analyze prognostic factors for survival].

Cai W, Yuan YC, Li MY, Kong W, Dong BJ, Chen YH, Zhang J, Xue W, Huang YR, Zhou LX, Huang JW. Cai W, et al. Zhonghua Zhong Liu Za Zhi. 2018 May 23;40(5):384-389. doi: 10.3760/cma.j.issn.0253-3766.2018.05.012. Zhonghua Zhong Liu Za Zhi. 2018. PMID: 29860767 Chinese.

First-line tyrosine kinase inhibitors in metastatic renal cell carcinoma: A regional cancer center experience.

Rudresha AH, Chaudhuri T, Lakshmaiah KC, Babu GK, Lokanatha D, Jacob LA, Suresh Babu MC, Lokesh KN, Rajeev LK. Rudresha AH, et al. Indian J Cancer. 2017 Oct-Dec;54(4):626-630. doi: 10.4103/ijc.IJC_380_17. Indian J Cancer. 2017. PMID: 30082547 Free article.

Second line treatment of metastatic renal cell carcinoma: The Institut Gustave Roussy experience with targeted therapies in 251 consecutive patients.

Levy A, Menard J, Albiges L, Loriot Y, Di Palma M, Fizazi K, Escudier B. Levy A, et al. Eur J Cancer. 2013 May;49(8):1898-904. doi: 10.1016/j.ejca.2013.02.003. Epub 2013 Mar 13. Eur J Cancer. 2013. PMID: 23490648

Real-world costs and outcomes in metastatic renal cell carcinoma patients treated with targeted therapies: a cohort study from the French health insurance database.

Maroun R, Fleury L, Nachbaur G, Maunoury F, Vanhille JL, Durand-Zaleski I. Maroun R, et al. Curr Med Res Opin. 2017 Oct;33(10):1755-1762. doi: 10.1080/03007995.2017.1360850. Epub 2017 Aug 7. Curr Med Res Opin. 2017. PMID: 28748721

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