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Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression.

Kopecki Z, Yang GN, Jackson JE, Melville EL, Calley MP, Murrell DF, Darby IA, O'Toole EA, Samuel MS, Cowin AJ.

Oncotarget. 2015 Nov 3;6(34):36426-40. doi: 10.18632/oncotarget.5536.


Attenuation of Flightless I, an actin-remodelling protein, improves burn injury repair via modulation of transforming growth factor (TGF)-beta1 and TGF-beta3.

Adams DH, Ruzehaji N, Strudwick XL, Greenwood JE, Campbell HD, Arkell R, Cowin AJ.

Br J Dermatol. 2009 Aug;161(2):326-36. doi: 10.1111/j.1365-2133.2009.09296.x. Epub 2009 Jun 9.


Flightless I is a key regulator of the fibroproliferative process in hypertrophic scarring and a target for a novel antiscarring therapy.

Cameron AM, Turner CT, Adams DH, Jackson JE, Melville E, Arkell RM, Anderson PJ, Cowin AJ.

Br J Dermatol. 2016 Apr;174(4):786-94. doi: 10.1111/bjd.14263. Epub 2016 Jan 9.


Overexpression of the Flii gene increases dermal-epidermal blistering in an autoimmune ColVII mouse model of epidermolysis bullosa acquisita.

Kopecki Z, Arkell RM, Strudwick XL, Hirose M, Ludwig RJ, Kern JS, Bruckner-Tuderman L, Zillikens D, Murrell DF, Cowin AJ.

J Pathol. 2011 Nov;225(3):401-13. doi: 10.1002/path.2973. Epub 2011 Sep 26.


Reducing Flightless I expression decreases severity of psoriasis in an imiquimod-induced murine model of psoriasiform dermatitis.

Chong HT, Yang GN, Sidhu S, Ibbetson J, Kopecki Z, Cowin AJ.

Br J Dermatol. 2017 Mar;176(3):705-712. doi: 10.1111/bjd.14842. Epub 2016 Dec 10.


Restoration of S100A4 expression enhances invasive and metastatic potentials of COLO16 cutaneous squamous cancer cells.

Yu LJ, Li Y, Li C, Li H, Wu ML, Liu ZL, Kong QY, Chen XY, Liu XY, An LJ, Liu J.

Cancer Biomark. 2014;14(5):325-33. doi: 10.3233/CBM-140414.


Flightless I regulates hemidesmosome formation and integrin-mediated cellular adhesion and migration during wound repair.

Kopecki Z, Arkell R, Powell BC, Cowin AJ.

J Invest Dermatol. 2009 Aug;129(8):2031-45. doi: 10.1038/jid.2008.461. Epub 2009 Feb 12.


Flightless I Homolog Represses Prostate Cancer Progression through Targeting Androgen Receptor Signaling.

Wang T, Song W, Chen Y, Chen R, Liu Z, Wu L, Li M, Yang J, Wang L, Liu J, Ye Z, Wang C, Chen K.

Clin Cancer Res. 2016 Mar 15;22(6):1531-44. doi: 10.1158/1078-0432.CCR-15-1632. Epub 2015 Nov 2.


Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK.

Xu J, Liao L, Qin J, Xu J, Liu D, Songyang Z.

J Biol Chem. 2009 May 22;284(21):14377-85. doi: 10.1074/jbc.M807770200. Epub 2009 Mar 17.


Mouse strains for the ubiquitous or conditional overexpression of the Flii gene.

Thomsen N, Chappell A, Ali RG, Jones T, Adams DH, Matthaei KI, Campbell HD, Cowin AJ, Arkell RM.

Genesis. 2011 Aug;49(8):681-8. doi: 10.1002/dvg.20735. Epub 2011 Jul 22.


The flightless I protein interacts with RNA-binding proteins and is involved in the genome-wide mRNA post-transcriptional regulation in lung carcinoma cells.

Wang C, Chen K, Liao S, Gu W, Lian X, Zhang J, Gao X, Liu X, Wang T, He QY, Zhang G, Liu L.

Int J Oncol. 2017 Jul;51(1):347-361. doi: 10.3892/ijo.2017.3995. Epub 2017 May 11.


Regulation of focal adhesions by flightless i involves inhibition of paxillin phosphorylation via a Rac1-dependent pathway.

Kopecki Z, O'Neill GM, Arkell RM, Cowin AJ.

J Invest Dermatol. 2011 Jul;131(7):1450-9. doi: 10.1038/jid.2011.69. Epub 2011 Mar 24.


Cytoskeletal protein Flightless (Flii) is elevated in chronic and acute human wounds and wound fluid: neutralizing its activity in chronic but not acute wound fluid improves cellular proliferation.

Ruzehaji N, Grose R, Krumbiegel D, Zola H, Dasari P, Wallace H, Stacey M, Fitridge R, Cowin AJ.

Eur J Dermatol. 2012 Nov-Dec;22(6):740-50. doi: 10.1684/ejd.2012.1878.


S100A7 acts as a dual regulator in promoting proliferation and suppressing squamous differentiation through GATA-3/caspase-14 pathway in A431 cells.

Li T, Qi Z, Kong F, Li Y, Wang R, Zhang W, Shang Y, Huang L, He D, Xiao X.

Exp Dermatol. 2015 May;24(5):342-8. doi: 10.1111/exd.12645. Epub 2015 Mar 9.


Flightless, secreted through a late endosome/lysosome pathway, binds LPS and dampens cytokine secretion.

Lei N, Franken L, Ruzehaji N, Offenhäuser C, Cowin AJ, Murray RZ.

J Cell Sci. 2012 Sep 15;125(Pt 18):4288-96. doi: 10.1242/jcs.099507. Epub 2012 Jun 20.


Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma.

Loercher A, Lee TL, Ricker JL, Howard A, Geoghegen J, Chen Z, Sunwoo JB, Sitcheran R, Chuang EY, Mitchell JB, Baldwin AS Jr, Van Waes C.

Cancer Res. 2004 Sep 15;64(18):6511-23. Erratum in: Cancer Res. 2004 Nov 1;64(21):8130-2.


Flightless I deficiency enhances wound repair by increasing cell migration and proliferation.

Cowin AJ, Adams DH, Strudwick XL, Chan H, Hooper JA, Sander GR, Rayner TE, Matthaei KI, Powell BC, Campbell HD.

J Pathol. 2007 Apr;211(5):572-81.


Attenuation of flightless I improves wound healing and enhances angiogenesis in a murine model of type 1 diabetes.

Ruzehaji N, Kopecki Z, Melville E, Appleby SL, Bonder CS, Arkell RM, Fitridge R, Cowin AJ.

Diabetologia. 2014 Feb;57(2):402-12. doi: 10.1007/s00125-013-3107-6. Epub 2013 Nov 29.


Slit2 promotes tumor growth and invasion in chemically induced skin carcinogenesis.

Qi C, Lan H, Ye J, Li W, Wei P, Yang Y, Guo S, Lan T, Li J, Zhang Q, He X, Wang L.

Lab Invest. 2014 Jul;94(7):766-76. doi: 10.1038/labinvest.2014.70. Epub 2014 May 19.

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