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Items: 1 to 20 of 97

1.

Altered kynurenine pathway metabolism in autism: Implication for immune-induced glutamatergic activity.

Lim CK, Essa MM, de Paula Martins R, Lovejoy DB, Bilgin AA, Waly MI, Al-Farsi YM, Al-Sharbati M, Al-Shaffae MA, Guillemin GJ.

Autism Res. 2016 Jun;9(6):621-31. doi: 10.1002/aur.1565. Epub 2015 Oct 24.

PMID:
26497015
2.

Kynurenine Pathway in Autism Spectrum Disorders in Children.

Bryn V, Verkerk R, Skjeldal OH, Saugstad OD, Ormstad H.

Neuropsychobiology. 2017;76(2):82-88. doi: 10.1159/000488157. Epub 2018 Apr 25.

PMID:
29694960
3.

Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism.

Gevi F, Zolla L, Gabriele S, Persico AM.

Mol Autism. 2016 Nov 24;7:47. eCollection 2016.

4.

Involvement of the kynurenine pathway in the pathogenesis of Parkinson's disease.

Lim CK, Fernández-Gomez FJ, Braidy N, Estrada C, Costa C, Costa S, Bessede A, Fernandez-Villalba E, Zinger A, Herrero MT, Guillemin GJ.

Prog Neurobiol. 2017 Aug;155:76-95. doi: 10.1016/j.pneurobio.2015.12.009. Epub 2016 Apr 9. Review.

PMID:
27072742
5.

Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases.

Lovelace MD, Varney B, Sundaram G, Lennon MJ, Lim CK, Jacobs K, Guillemin GJ, Brew BJ.

Neuropharmacology. 2017 Jan;112(Pt B):373-388. doi: 10.1016/j.neuropharm.2016.03.024. Epub 2016 Mar 16. Review.

PMID:
26995730
6.

Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals.

Clark SM, Pocivavsek A, Nicholson JD, Notarangelo FM, Langenberg P, McMahon RP, Kleinman JE, Hyde TM, Stiller J, Postolache TT, Schwarcz R, Tonelli LH.

J Psychiatry Neurosci. 2016 Oct;41(6):386-394.

7.

Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression.

Laugeray A, Launay JM, Callebert J, Surget A, Belzung C, Barone PR.

Behav Brain Res. 2010 Jun 26;210(1):84-91. doi: 10.1016/j.bbr.2010.02.014. Epub 2010 Feb 12.

PMID:
20153778
8.

Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans.

Yan EB, Frugier T, Lim CK, Heng B, Sundaram G, Tan M, Rosenfeld JV, Walker DW, Guillemin GJ, Morganti-Kossmann MC.

J Neuroinflammation. 2015 May 30;12:110. doi: 10.1186/s12974-015-0328-2.

9.

Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired blood-brain barrier integrity.

Steiner J, Bogerts B, Sarnyai Z, Walter M, Gos T, Bernstein HG, Myint AM.

World J Biol Psychiatry. 2012 Oct;13(7):482-92. doi: 10.3109/15622975.2011.583941. Epub 2011 Jun 28. Review.

PMID:
21707463
10.

Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition.

Zavitsanou K, Lim CK, Purves-Tyson T, Karl T, Kassiou M, Banister SD, Guillemin GJ, Weickert CS.

Brain Behav Immun. 2014 Oct;41:173-81. doi: 10.1016/j.bbi.2014.05.011. Epub 2014 May 27.

PMID:
24878170
11.

L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: Focus on cell type differences.

Fujigaki H, Yamamoto Y, Saito K.

Neuropharmacology. 2017 Jan;112(Pt B):264-274. doi: 10.1016/j.neuropharm.2016.01.011. Epub 2016 Jan 6. Review.

PMID:
26767951
12.

Abnormalities in Kynurenine Pathway Metabolism in Treatment-Resistant Depression and Suicidality: A Systematic Review.

Serafini G, Adavastro G, Canepa G, Capobianco L, Conigliaro C, Pittaluga F, Murri MB, Valchera A, De Berardis D, Pompili M, Lindqvist D, Brundin L, Amore M.

CNS Neurol Disord Drug Targets. 2017;16(4):440-453. doi: 10.2174/1871527316666170413110605. Review.

PMID:
28412922
13.

Kynurenines and Glutamate: Multiple Links and Therapeutic Implications.

Schwarcz R.

Adv Pharmacol. 2016;76:13-37. doi: 10.1016/bs.apha.2016.01.005. Epub 2016 Mar 11. Review.

14.

Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis.

Lovelace MD, Varney B, Sundaram G, Franco NF, Ng ML, Pai S, Lim CK, Guillemin GJ, Brew BJ.

Front Immunol. 2016 Aug 4;7:246. doi: 10.3389/fimmu.2016.00246. eCollection 2016. Review.

15.

The kynurenine pathway and neurodegenerative disease.

Maddison DC, Giorgini F.

Semin Cell Dev Biol. 2015 Apr;40:134-41. doi: 10.1016/j.semcdb.2015.03.002. Epub 2015 Mar 12. Review.

PMID:
25773161
16.

Understanding the role of the kynurenine pathway in human breast cancer immunobiology.

Heng B, Lim CK, Lovejoy DB, Bessede A, Gluch L, Guillemin GJ.

Oncotarget. 2016 Feb 9;7(6):6506-20. doi: 10.18632/oncotarget.6467. Review.

17.

Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease.

Mazarei G, Budac DP, Lu G, Adomat H, Tomlinson Guns ES, Möller T, Leavitt BR.

J Neurochem. 2013 Dec;127(6):852-67. doi: 10.1111/jnc.12350. Epub 2013 Jul 15.

18.

Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART.

Drewes JL, Meulendyke KA, Liao Z, Witwer KW, Gama L, Ubaida-Mohien C, Li M, Notarangelo FM, Tarwater PM, Schwarcz R, Graham DR, Zink MC.

J Neurovirol. 2015 Aug;21(4):449-63. doi: 10.1007/s13365-015-0334-2. Epub 2015 Mar 17.

19.

Role of Kynurenine Metabolism Pathway Activation in Major Depressive Disorders.

Savitz J.

Curr Top Behav Neurosci. 2017;31:249-267. doi: 10.1007/7854_2016_12. Review.

PMID:
27221627
20.

The urinary 1 H-NMR metabolomics profile of an italian autistic children population and their unaffected siblings.

Lussu M, Noto A, Masili A, Rinaldi AC, Dessì A, De Angelis M, De Giacomo A, Fanos V, Atzori L, Francavilla R.

Autism Res. 2017 Jun;10(6):1058-1066. doi: 10.1002/aur.1748. Epub 2017 Mar 11.

PMID:
28296209

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