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Items: 1 to 20 of 141

1.

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells.

Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJ, Klenerman P, Sharpe AH, Lauer GM, Haining WN.

PLoS Pathog. 2015 Oct 20;11(10):e1005177. doi: 10.1371/journal.ppat.1005177. eCollection 2015 Oct.

2.

On the role of the inhibitory receptor LAG-3 in acute and chronic LCMV infection.

Richter K, Agnellini P, Oxenius A.

Int Immunol. 2010 Jan;22(1):13-23. doi: 10.1093/intimm/dxp107. Epub 2009 Oct 30.

PMID:
19880580
3.

Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults.

Duraiswamy J, Ibegbu CC, Masopust D, Miller JD, Araki K, Doho GH, Tata P, Gupta S, Zilliox MJ, Nakaya HI, Pulendran B, Haining WN, Freeman GJ, Ahmed R.

J Immunol. 2011 Apr 1;186(7):4200-12. doi: 10.4049/jimmunol.1001783. Epub 2011 Mar 7.

4.

Follicular CXCR5- expressing CD8(+) T cells curtail chronic viral infection.

He R, Hou S, Liu C, Zhang A, Bai Q, Han M, Yang Y, Wei G, Shen T, Yang X, Xu L, Chen X, Hao Y, Wang P, Zhu C, Ou J, Liang H, Ni T, Zhang X, Zhou X, Deng K, Chen Y, Luo Y, Xu J, Qi H, Wu Y, Ye L.

Nature. 2016 Aug 2;537(7620):412-428. doi: 10.1038/nature19317. Erratum in: Nature. 2016 Oct 19;540(7633):470.

PMID:
27501245
5.

Functional restoration of exhausted CD4(+) and CD8(+) T cells in chronic viral infection by vinegar-processed flos of Daphne genkwa.

Uyangaa E, Choi JY, Patil AM, Kim JH, Kim SB, Kim K, Ryu HW, Oh SR, Eo SK.

Comp Immunol Microbiol Infect Dis. 2015 Apr;39:25-37. doi: 10.1016/j.cimid.2015.02.001. Epub 2015 Feb 16.

PMID:
25744061
6.

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection.

Jin HT, Anderson AC, Tan WG, West EE, Ha SJ, Araki K, Freeman GJ, Kuchroo VK, Ahmed R.

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14733-8. doi: 10.1073/pnas.1009731107. Epub 2010 Aug 2.

7.

Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade.

Blackburn SD, Shin H, Freeman GJ, Wherry EJ.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15016-21. doi: 10.1073/pnas.0801497105. Epub 2008 Sep 22.

8.

Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection.

Blattman JN, Wherry EJ, Ha SJ, van der Most RG, Ahmed R.

J Virol. 2009 May;83(9):4386-94. doi: 10.1128/JVI.02524-08. Epub 2009 Feb 11.

9.

T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections.

Utzschneider DT, Charmoy M, Chennupati V, Pousse L, Ferreira DP, Calderon-Copete S, Danilo M, Alfei F, Hofmann M, Wieland D, Pradervand S, Thimme R, Zehn D, Held W.

Immunity. 2016 Aug 16;45(2):415-27. doi: 10.1016/j.immuni.2016.07.021.

10.

Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion.

Blackburn SD, Crawford A, Shin H, Polley A, Freeman GJ, Wherry EJ.

J Virol. 2010 Feb;84(4):2078-89. doi: 10.1128/JVI.01579-09. Epub 2009 Dec 2.

11.

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, Betts MR, Freeman GJ, Vignali DA, Wherry EJ.

Nat Immunol. 2009 Jan;10(1):29-37. doi: 10.1038/ni.1679. Epub 2008 Nov 30.

12.

Id3 Controls Cell Death of 2B4+ Virus-Specific CD8+ T Cells in Chronic Viral Infection.

Menner AJ, Rauch KS, Aichele P, Pircher H, Schachtrup C, Schachtrup K.

J Immunol. 2015 Sep 1;195(5):2103-14. doi: 10.4049/jimmunol.1402607. Epub 2015 Jul 31.

13.

Polymicrobial Sepsis Increases Susceptibility to Chronic Viral Infection and Exacerbates CD8+ T Cell Exhaustion.

Condotta SA, Khan SH, Rai D, Griffith TS, Badovinac VP.

J Immunol. 2015 Jul 1;195(1):116-25. doi: 10.4049/jimmunol.1402473. Epub 2015 May 15.

14.

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy.

Im SJ, Hashimoto M, Gerner MY, Lee J, Kissick HT, Burger MC, Shan Q, Hale JS, Lee J, Nasti TH, Sharpe AH, Freeman GJ, Germain RN, Nakaya HI, Xue HH, Ahmed R.

Nature. 2016 Sep 15;537(7620):417-421. doi: 10.1038/nature19330. Epub 2016 Aug 2.

15.

A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection.

Shin H, Blackburn SD, Intlekofer AM, Kao C, Angelosanto JM, Reiner SL, Wherry EJ.

Immunity. 2009 Aug 21;31(2):309-20. doi: 10.1016/j.immuni.2009.06.019. Epub 2009 Aug 6.

16.

Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection.

Hoffmann M, Pantazis N, Martin GE, Hickling S, Hurst J, Meyerowitz J, Willberg CB, Robinson N, Brown H, Fisher M, Kinloch S, Babiker A, Weber J, Nwokolo N, Fox J, Fidler S, Phillips R, Frater J; SPARTAC and CHERUB Investigators.

PLoS Pathog. 2016 Jul 14;12(7):e1005661. doi: 10.1371/journal.ppat.1005661. eCollection 2016 Jul.

17.

Progressive loss of memory T cell potential and commitment to exhaustion during chronic viral infection.

Angelosanto JM, Blackburn SD, Crawford A, Wherry EJ.

J Virol. 2012 Aug;86(15):8161-70. doi: 10.1128/JVI.00889-12. Epub 2012 May 23.

18.

IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection.

Beltra JC, Bourbonnais S, Bédard N, Charpentier T, Boulangé M, Michaud E, Boufaied I, Bruneau J, Shoukry NH, Lamarre A, Decaluwe H.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5444-53. doi: 10.1073/pnas.1604256113. Epub 2016 Aug 29.

19.

Restoring function in exhausted CD8 T cells during chronic viral infection.

Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, Freeman GJ, Ahmed R.

Nature. 2006 Feb 9;439(7077):682-7. Epub 2005 Dec 28.

PMID:
16382236
20.

Molecular signature of CD8+ T cell exhaustion during chronic viral infection.

Wherry EJ, Ha SJ, Kaech SM, Haining WN, Sarkar S, Kalia V, Subramaniam S, Blattman JN, Barber DL, Ahmed R.

Immunity. 2007 Oct;27(4):670-84. Epub 2007 Oct 18. Erratum in: Immunity. 2007 Nov;27(5):824.

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