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Items: 1 to 20 of 141

1.

Phosphodiesterase 1 regulation is a key mechanism in vascular aging.

Bautista Niño PK, Durik M, Danser AH, de Vries R, Musterd-Bhaggoe UM, Meima ME, Kavousi M, Ghanbari M, Hoeijmakers JH, O'Donnell CJ, Franceschini N, Janssen GM, De Mey JG, Liu Y, Shanahan CM, Franco OH, Dehghan A, Roks AJ.

Clin Sci (Lond). 2015 Dec;129(12):1061-75. doi: 10.1042/CS20140753. Epub 2015 Jun 25.

PMID:
26464516
2.

Cyclic nucleotide phosphodiesterase 1 and vascular aging.

Yan C.

Clin Sci (Lond). 2015 Dec;129(12):1077-81. doi: 10.1042/CS20150605. Epub 2015 Sep 15.

3.

Thrombospondin-1 inhibition of vascular smooth muscle cell responses occurs via modulation of both cAMP and cGMP.

Yao M, Roberts DD, Isenberg JS.

Pharmacol Res. 2011 Jan;63(1):13-22. doi: 10.1016/j.phrs.2010.10.014. Epub 2010 Oct 29.

4.

Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells.

Cai Y, Miller CL, Nagel DJ, Jeon KI, Lim S, Gao P, Knight PA, Yan C.

Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):616-23. doi: 10.1161/ATVBAHA.110.212621. Epub 2010 Dec 9.

5.

Nucleotide excision DNA repair is associated with age-related vascular dysfunction.

Durik M, Kavousi M, van der Pluijm I, Isaacs A, Cheng C, Verdonk K, Loot AE, Oeseburg H, Bhaggoe UM, Leijten F, van Veghel R, de Vries R, Rudez G, Brandt R, Ridwan YR, van Deel ED, de Boer M, Tempel D, Fleming I, Mitchell GF, Verwoert GC, Tarasov KV, Uitterlinden AG, Hofman A, Duckers HJ, van Duijn CM, Oostra BA, Witteman JC, Duncker DJ, Danser AH, Hoeijmakers JH, Roks AJ.

Circulation. 2012 Jul 24;126(4):468-78. doi: 10.1161/CIRCULATIONAHA.112.104380. Epub 2012 Jun 15.

6.

PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries.

Khammy MM, Dalsgaard T, Larsen PH, Christoffersen CT, Clausen D, Rasmussen LK, Folkersen L, Grunnet M, Kehler J, Aalkjaer C, Nielsen J.

Br J Pharmacol. 2017 Nov;174(22):4186-4198. doi: 10.1111/bph.14034. Epub 2017 Oct 15.

7.

PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries.

Santos-Silva AJ, Cairrão E, Morgado M, Alvarez E, Verde I.

Eur J Pharmacol. 2008 Mar 17;582(1-3):102-9. doi: 10.1016/j.ejphar.2007.12.017. Epub 2007 Dec 28.

PMID:
18234184
8.

Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia.

Cai Y, Nagel DJ, Zhou Q, Cygnar KD, Zhao H, Li F, Pi X, Knight PA, Yan C.

Circ Res. 2015 Mar 27;116(7):1120-32. doi: 10.1161/CIRCRESAHA.116.304408. Epub 2015 Jan 21.

9.

Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension.

Pojoga LH, Williams JS, Yao TM, Kumar A, Raffetto JD, do Nascimento GR, Reslan OM, Adler GK, Williams GH, Shi Y, Khalil RA.

Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1862-71. doi: 10.1152/ajpheart.00513.2011. Epub 2011 Aug 26.

10.

Differential expression of multidrug resistance protein 5 and phosphodiesterase 5 and regulation of cGMP levels in phasic and tonic smooth muscle.

Al-Shboul O, Mahavadi S, Sriwai W, Grider JR, Murthy KS.

Am J Physiol Gastrointest Liver Physiol. 2013 Aug 15;305(4):G314-24. doi: 10.1152/ajpgi.00457.2012. Epub 2013 Jun 13.

11.

Vasodilatory activity and antihypertensive profile mediated by inhibition of phosphodiesterase type 1 induced by a novel sulfonamide compound.

Pontes LB, Antunes F, Sudo RT, Raimundo JM, Lima LM, Barreiro EJ, Zapata-Sudo G.

Fundam Clin Pharmacol. 2012 Dec;26(6):690-700. doi: 10.1111/j.1472-8206.2011.00999.x. Epub 2011 Nov 9.

PMID:
22066694
12.

Phosphodiesterase 5 inhibition ameliorates angiotensin II-dependent hypertension and renal vascular dysfunction.

Thieme M, Sivritas SH, Mergia E, Potthoff SA, Yang G, Hering L, Grave K, Hoch H, Rump LC, Stegbauer J.

Am J Physiol Renal Physiol. 2017 Mar 1;312(3):F474-F481. doi: 10.1152/ajprenal.00376.2016. Epub 2017 Jan 4.

13.

Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance.

Kim D, Rybalkin SD, Pi X, Wang Y, Zhang C, Munzel T, Beavo JA, Berk BC, Yan C.

Circulation. 2001 Nov 6;104(19):2338-43.

PMID:
11696475
14.

Phosphodiesterase 5 and effects of sildenafil on cerebral arteries of man and guinea pig.

Kruuse C, Khurana TS, Rybalkin SD, Birk S, Engel U, Edvinsson L, Olesen J.

Eur J Pharmacol. 2005 Oct 3;521(1-3):105-14. Epub 2005 Sep 21.

PMID:
16182282
15.

Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure.

Lakshmikanthan S, Zieba BJ, Ge ZD, Momotani K, Zheng X, Lund H, Artamonov MV, Maas JE, Szabo A, Zhang DX, Auchampach JA, Mattson DL, Somlyo AV, Chrzanowska-Wodnicka M.

Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1486-94. doi: 10.1161/ATVBAHA.114.303678. Epub 2014 May 1.

16.

Brief hyperoxia increases mitochondrial oxidation and increases phosphodiesterase 5 activity in fetal pulmonary artery smooth muscle cells.

Farrow KN, Lee KJ, Perez M, Schriewer JM, Wedgwood S, Lakshminrusimha S, Smith CL, Steinhorn RH, Schumacker PT.

Antioxid Redox Signal. 2012 Aug 1;17(3):460-70. doi: 10.1089/ars.2011.4184. Epub 2012 Mar 8.

17.

H2O2 regulation of vascular function through sGC mRNA stabilization by HuR.

Martín-Garrido A, González-Ramos M, Griera M, Guijarro B, Cannata-Andia J, Rodriguez-Puyol D, Rodriguez-Puyol M, Saura M.

Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):567-73. doi: 10.1161/ATVBAHA.110.219725. Epub 2010 Dec 16.

PMID:
21164076
18.

Tirofiban increases soluble guanylate cyclase in rat vascular walls: pharmacological and pathophysiological consequences.

Ruiz-Torres MP, Griera M, Chamorro A, Díez-Marqués ML, Rodríguez-Puyol D, Rodríguez-Puyol M.

Cardiovasc Res. 2009 Apr 1;82(1):125-32. doi: 10.1093/cvr/cvn359. Epub 2009 Jan 6.

PMID:
19126601
19.

Inhibition of cGMP phosphodiesterase 5 suppresses matrix metalloproteinase-2 production in pulmonary artery smooth muscles cells.

Sun XZ, Li ZF, Liu Y, Fang P, Li MX.

Clin Exp Pharmacol Physiol. 2010 Mar;37(3):362-7. doi: 10.1111/j.1440-1681.2009.05304.x. Epub 2009 Sep 28.

PMID:
19793106
20.

Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells.

von Hayn K, Werthmann RC, Nikolaev VO, Hommers LG, Lohse MJ, Bünemann M.

Am J Physiol Cell Physiol. 2010 Feb;298(2):C324-32. doi: 10.1152/ajpcell.00197.2009. Epub 2009 Nov 4.

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