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Items: 1 to 20 of 183

1.

Synthesis of 1'-C-cyano pyrimidine nucleosides and characterization as HCV polymerase inhibitors.

Kirschberg TA, Mish M, Squires NH, Zonte S, Aktoudianakis E, Metobo S, Butler T, Ju X, Cho A, Ray AS, Kim CU.

Nucleosides Nucleotides Nucleic Acids. 2015;34(11):763-85. doi: 10.1080/15257770.2015.1075550. Epub 2015 Sep 23.

PMID:
26398773
2.

Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.

Mish MR, Cho A, Kirschberg T, Xu J, Zonte CS, Fenaux M, Park Y, Babusis D, Feng JY, Ray AS, Kim CU.

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3092-5. doi: 10.1016/j.bmcl.2014.05.015. Epub 2014 May 22.

PMID:
24907145
3.

Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.

Kirschberg TA, Mish MR, Zhang L, Squires NH, Wang KY, Cho A, Feng JY, Fenaux M, Babusis D, Park Y, Ray AS, Kim CU.

Bioorg Med Chem Lett. 2015 Mar 1;25(5):1040-3. doi: 10.1016/j.bmcl.2015.01.021. Epub 2015 Jan 17.

PMID:
25650256
4.

[4'-C-modified nucleosides: synthesis and antiviral properties].

Aleksandrova LA.

Bioorg Khim. 2011 Nov-Dec;37(6):723-44. Review. Russian.

PMID:
22497074
5.

Furano- and pyrrolo [2,3-d] pyrimidine nucleosides and their 5'-O-triphospates: synthesis and enzymatic activity.

Alexandrova LA, Ivanov MA, Victorova LS, Kukhanova MK.

Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):1083-6.

PMID:
18058541
6.

Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs.

Rondla R, Coats SJ, McBrayer TR, Grier J, Johns M, Tharnish PM, Whitaker T, Zhou L, Schinazi RF.

Antivir Chem Chemother. 2009 Oct 19;20(2):99-106. doi: 10.3851/IMP1400.

PMID:
19843980
7.

Synthesis and biological evaluation of pyrimidine nucleoside monophosphate prodrugs targeted against influenza virus.

Meneghesso S, Vanderlinden E, Stevaert A, McGuigan C, Balzarini J, Naesens L.

Antiviral Res. 2012 Apr;94(1):35-43. doi: 10.1016/j.antiviral.2012.01.007. Epub 2012 Jan 28.

PMID:
22306172
8.

Synthesis of 2'-fluoro and 2',4'-dimethyl pyrimidine C-nucleoside analogues as potential anti-HCV agents.

Liu LJ, Hong JH.

Nucleosides Nucleotides Nucleic Acids. 2010 Mar;29(3):216-27. doi: 10.1080/15257771003705617.

PMID:
20408052
9.

Valopicitabine dihydrochloride:a specific polymerase inhibitor of hepatitis C virus.

Toniutto P, Fabris C, Bitetto D, Fornasiere E, Rapetti R, Pirisi M.

Curr Opin Investig Drugs. 2007 Feb;8(2):150-8. Review.

PMID:
17328231
10.

Synthetic strategies toward carbocyclic purine-pyrimidine hybrid nucleosides.

Sadler JM, Mosley SL, Dorgan KM, Zhou ZS, Seley-Radtke KL.

Bioorg Med Chem. 2009 Aug 1;17(15):5520-5. doi: 10.1016/j.bmc.2009.06.039. Epub 2009 Jun 23.

11.

Disaccharide pyrimidine nucleosides and their derivatives: a novel group of cell-penetrating inhibitors of poly(ADP-ribose) polymerase 1.

Efremova AS, Zakharenko AL, Shram SI, Kulikova IV, Drenichev MS, Sukhanova MV, Khodyreva SN, Myasoedov NF, Lavrik OI, Mikhailov SN.

Nucleosides Nucleotides Nucleic Acids. 2013;32(9):510-28. doi: 10.1080/15257770.2013.827793.

PMID:
24079274
12.

Synthesis and anti-hepatitis C virus (HCV) activity of 3'-C-substituted-methyl pyrimidine and purine nucleosides.

Choi WJ, Kim YM, Kim HO, Lee HW, Kim DE, Park KS, Chong Y, Jeong LS.

Bioorg Med Chem. 2010 Jul 1;18(13):4812-20. doi: 10.1016/j.bmc.2010.05.002. Epub 2010 May 31.

PMID:
20627592
13.

Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors.

Cho A, Zhang L, Xu J, Babusis D, Butler T, Lee R, Saunders OL, Wang T, Parrish J, Perry J, Feng JY, Ray AS, Kim CU.

Bioorg Med Chem Lett. 2012 Jun 15;22(12):4127-32. doi: 10.1016/j.bmcl.2012.04.065. Epub 2012 Apr 20.

PMID:
22578461
14.

Phosphoramidate prodrugs deliver with potency against hepatitis C virus.

Mehellou Y.

ChemMedChem. 2010 Nov 8;5(11):1841-2. doi: 10.1002/cmdc.201000310. No abstract available.

PMID:
20865770
15.

Branched-chain C-cyano pyranonucleosides: synthesis of 3'-C-cyano & 3'-C-cyano-3'-deoxy pyrimidine pyranonucleosides as novel cytotoxic agents.

Kiritsis C, Manta S, Parmenopoulou V, Balzarini J, Komiotis D.

Eur J Med Chem. 2011 Nov;46(11):5668-74. doi: 10.1016/j.ejmech.2011.08.033. Epub 2011 Sep 1.

PMID:
21917363
16.

Synthesis of 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-hepatitis C virus (HCV) agents.

Pei X, Choi WJ, Kim YM, Zhao LX, Jeong LS.

Arch Pharm Res. 2008 Jul;31(7):843-9. doi: 10.1007/s12272-001-1236-z. Epub 2008 Aug 14.

PMID:
18704325
17.

Synthesis and evaluation of multisubstrate bicyclic pyrimidine nucleoside inhibitors of human thymidine phosphorylase.

Allan AL, Gladstone PL, Price ML, Hopkins SA, Juarez JC, Doñate F, Ternansky RJ, Shaw DE, Ganem B, Li Y, Wang W, Ealick S.

J Med Chem. 2006 Dec 28;49(26):7807-15.

PMID:
17181163
18.

Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.

Bennett F, Kezar HS 3rd, Girijavallabhan V, Huang Y, Huelgas R, Rossman R, Shih NY, Piwinski JJ, MacCoss M, Kwong CD, Clark JL, Fowler AT, Geng F, Roychowdhury A, Reynolds RC, Maddry JA, Ananthan S, Secrist JA 3rd, Li C, Chase R, Curry S, Huang HC, Tong X, George Njoroge F, Arasappan A.

Bioorg Med Chem Lett. 2012 Aug 1;22(15):5144-9. doi: 10.1016/j.bmcl.2012.06.021. Epub 2012 Jun 19.

PMID:
22814211
19.

Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma.

Pomeisl K, Votruba I, Holý A, Pohl R.

Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):1025-8.

PMID:
18058530
20.

Synthesis and evaluation of ATP-binding site directed potential inhibitors of nucleoside triphosphatases/helicases and polymerases of hepatitis C and other selected Flaviviridae viruses.

Bretner M, Schalinski S, Haag A, Lang M, Schmitz H, Baier A, Behrens SE, Kulikowski T, Borowski P.

Antivir Chem Chemother. 2004 Jan;15(1):35-42.

PMID:
15074713

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