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Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.

Zhu L, Zhong M, Elder GA, Sano M, Holtzman DM, Gandy S, Cardozo C, Haroutunian V, Robakis NK, Cai D.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11965-70. doi: 10.1073/pnas.1510011112. Epub 2015 Sep 8.


ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury.

Cao J, Gaamouch FE, Meabon JS, Meeker KD, Zhu L, Zhong MB, Bendik J, Elder G, Jing P, Xia J, Luo W, Cook DG, Cai D.

Sci Rep. 2017 Sep 12;7(1):11372. doi: 10.1038/s41598-017-11654-7.


Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models.

Huang Y.

Biochem Soc Trans. 2011 Aug;39(4):924-32. doi: 10.1042/BST0390924.


Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y.

J Neurosci. 2004 Mar 10;24(10):2527-34.


Gene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice.

Engstrom AK, Snyder JM, Maeda N, Xia Z.

Mol Neurodegener. 2017 Feb 7;12(1):14. doi: 10.1186/s13024-017-0155-2. Erratum in: Mol Neurodegener. 2017 Nov 3;12(1):81.


In Thai Nationals, the ApoE4 Allele Affects Multiple Domains of Neuropsychological, Biobehavioral, and Social Functioning Thereby Contributing to Alzheimer's Disorder, while the ApoE3 Allele Protects Against Neuropsychiatric Symptoms and Psychosocial Deficits.

Tangwongchai S, Supasitthumrong T, Hemrunroj S, Tunvirachaisakul C, Chuchuen P, Houngngam N, Snabboon T, Tawankanjanachot I, Likitchareon Y, Phanthumchindad K, Maes M.

Mol Neurobiol. 2018 Aug;55(8):6449-6462. doi: 10.1007/s12035-017-0848-0. Epub 2018 Jan 6.


Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice.

Leung L, Andrews-Zwilling Y, Yoon SY, Jain S, Ring K, Dai J, Wang MM, Tong L, Walker D, Huang Y.

PLoS One. 2012;7(12):e53569. doi: 10.1371/journal.pone.0053569. Epub 2012 Dec 31.


Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice.

Ophir G, Meilin S, Efrati M, Chapman J, Karussis D, Roses A, Michaelson DM.

Neurobiol Dis. 2003 Feb;12(1):56-64.


Identification and modification of amyloid-independent phenotypes of APOE4 mice.

DiBattista AM, Dumanis SB, Newman J, Rebeck GW.

Exp Neurol. 2016 Jun;280:97-105. doi: 10.1016/j.expneurol.2016.04.014. Epub 2016 Apr 14.


Human apolipoprotein E4 modulates the expression of Pin1, Sirtuin 1, and Presenilin 1 in brain regions of targeted replacement apoE mice.

Lattanzio F, Carboni L, Carretta D, Rimondini R, Candeletti S, Romualdi P.

Neuroscience. 2014 Jan 3;256:360-9. doi: 10.1016/j.neuroscience.2013.10.017. Epub 2013 Oct 23.


PKR Inhibition Rescues Memory Deficit and ATF4 Overexpression in ApoE ε4 Human Replacement Mice.

Segev Y, Barrera I, Ounallah-Saad H, Wibrand K, Sporild I, Livne A, Rosenberg T, David O, Mints M, Bramham CR, Rosenblum K.

J Neurosci. 2015 Sep 23;35(38):12986-93. doi: 10.1523/JNEUROSCI.5241-14.2015.


Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice.

Zhong N, Scearce-Levie K, Ramaswamy G, Weisgraber KH.

Alzheimers Dement. 2008 May;4(3):179-92. doi: 10.1016/j.jalz.2008.01.006.


Cellular source-specific effects of apolipoprotein (apo) E4 on dendrite arborization and dendritic spine development.

Jain S, Yoon SY, Leung L, Knoferle J, Huang Y.

PLoS One. 2013;8(3):e59478. doi: 10.1371/journal.pone.0059478. Epub 2013 Mar 19.


Apolipoprotein E4 Causes Age-Dependent Disruption of Slow Gamma Oscillations during Hippocampal Sharp-Wave Ripples.

Gillespie AK, Jones EA, Lin YH, Karlsson MP, Kay K, Yoon SY, Tong LM, Nova P, Carr JS, Frank LM, Huang Y.

Neuron. 2016 May 18;90(4):740-51. doi: 10.1016/j.neuron.2016.04.009. Epub 2016 May 5.


Intraneuronal amyloid-beta plays a role in mediating the synergistic pathological effects of apoE4 and environmental stimulation.

Levi O, Dolev I, Belinson H, Michaelson DM.

J Neurochem. 2007 Nov;103(3):1031-40. Epub 2007 Jul 31.


Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2.

Vandal M, Alata W, Tremblay C, Rioux-Perreault C, Salem N Jr, Calon F, Plourde M.

J Neurochem. 2014 May;129(3):516-26. doi: 10.1111/jnc.12640. Epub 2014 Jan 29.


Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease.

Halliday MR, Rege SV, Ma Q, Zhao Z, Miller CA, Winkler EA, Zlokovic BV.

J Cereb Blood Flow Metab. 2016 Jan;36(1):216-27.

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