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Items: 1 to 20 of 92

1.

Synthesis and Characterization in Vitro and in Vivo of (l)-(Trimethylsilyl)alanine Containing Neurotensin Analogues.

Fanelli R, Besserer-Offroy É, René A, Côté J, Tétreault P, Collerette-Tremblay J, Longpré JM, Leduc R, Martinez J, Sarret P, Cavelier F.

J Med Chem. 2015 Oct 8;58(19):7785-95. doi: 10.1021/acs.jmedchem.5b00841. Epub 2015 Sep 16.

PMID:
26348111
2.

Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues.

Fanelli R, Floquet N, Besserer-Offroy É, Delort B, Vivancos M, Longpré JM, Renault P, Martinez J, Sarret P, Cavelier F.

J Med Chem. 2017 Apr 27;60(8):3303-3313. doi: 10.1021/acs.jmedchem.6b01848. Epub 2017 Apr 10.

PMID:
28368584
3.

Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity.

Roussy G, Dansereau MA, Baudisson S, Ezzoubaa F, Belleville K, Beaudet N, Martinez J, Richelson E, Sarret P.

Mol Pain. 2009 Jul 6;5:38. doi: 10.1186/1744-8069-5-38.

4.

NTS1 and NTS2 mediate analgesia following neurotensin analog treatment in a mouse model for visceral pain.

Smith KE, Boules M, Williams K, Richelson E.

Behav Brain Res. 2012 Jun 15;232(1):93-7. doi: 10.1016/j.bbr.2012.03.044. Epub 2012 Apr 5.

PMID:
22504145
5.

Synthesis and biological effects of c(Lys-Lys-Pro-Tyr-Ile-Leu-Lys-Lys-Pro-Tyr-Ile-Leu) (JMV2012), a new analogue of neurotensin that crosses the blood-brain barrier.

Bredeloux P, Cavelier F, Dubuc I, Vivet B, Costentin J, Martinez J.

J Med Chem. 2008 Mar 27;51(6):1610-6. doi: 10.1021/jm700925k. Epub 2008 Mar 6.

PMID:
18321036
6.

Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2.

Thomas JB, Giddings AM, Wiethe RW, Olepu S, Warner KR, Sarret P, Gendron L, Longpre JM, Zhang Y, Runyon SP, Gilmour BP.

J Med Chem. 2014 Sep 11;57(17):7472-7. doi: 10.1021/jm500857r. Epub 2014 Aug 26.

7.

Novel bioactive and stable neurotensin peptide analogues capable of delivering radiopharmaceuticals and molecular beacons to tumors.

Achilefu S, Srinivasan A, Schmidt MA, Jimenez HN, Bugaj JE, Erion JL.

J Med Chem. 2003 Jul 17;46(15):3403-11.

PMID:
12852770
8.

Potent spinal analgesia elicited through stimulation of NTS2 neurotensin receptors.

Sarret P, Esdaile MJ, Perron A, Martinez J, Stroh T, Beaudet A.

J Neurosci. 2005 Sep 7;25(36):8188-96.

9.

Synthesis of neurotensin(9-13) analogues exhibiting enhanced human neurotensin receptor binding affinities.

Lundquist JT 4th, Büllesbach EE, Dix TA.

Bioorg Med Chem Lett. 2000 Mar 6;10(5):453-5.

PMID:
10743946
10.

NTS2-selective neurotensin mimetics with tetrahydrofuran amino acids.

Simeth NA, Bause M, Dobmeier M, Kling RC, Lachmann D, Hübner H, Einsiedel J, Gmeiner P, König B.

Bioorg Med Chem. 2017 Jan 1;25(1):350-359. doi: 10.1016/j.bmc.2016.10.039. Epub 2016 Nov 1.

PMID:
27842797
11.

In vitro analysis of stable, receptor-selective neurotensin[8-13] analogues.

Kokko KP, Hadden MK, Orwig KS, Mazella J, Dix TA.

J Med Chem. 2003 Sep 11;46(19):4141-8.

PMID:
12954066
12.

Synthesis of a biologically active fluorescent probe for labeling neurotensin receptors.

Faure MP, Gaudreau P, Shaw I, Cashman NR, Beaudet A.

J Histochem Cytochem. 1994 Jun;42(6):755-63.

PMID:
8189037
13.

Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound.

Thomas JB, Giddings AM, Wiethe RW, Olepu S, Warner KR, Sarret P, Gendron L, Longpre JM, Zhang Y, Runyon SP, Gilmour BP.

J Med Chem. 2014 Jun 26;57(12):5318-32. doi: 10.1021/jm5003843. Epub 2014 Jun 5.

14.

In vivo and in vitro structure-activity studies with peptide and pseudopeptide neurotensin analogs suggest the existence of distinct central neurotensin receptor subtypes.

Labbé-Jullié C, Dubuc I, Brouard A, Doulut S, Bourdel E, Pelaprat D, Mazella J, Martinez J, Rostène W, Costentin J, et al.

J Pharmacol Exp Ther. 1994 Jan;268(1):328-36.

PMID:
8301574
15.

[Synthesis and study of cyclic and linear analogs of neurotensin].

Grinshteĭne IV, Myshliakova NV, Vegner RE, Vosekalna IA, Gaĭlite EA.

Bioorg Khim. 1985 Dec;11(12):1589-97. Russian.

PMID:
4084322
16.

Low-affinity neurotensin receptor (NTS2) signaling: internalization-dependent activation of extracellular signal-regulated kinases 1/2.

Gendron L, Perron A, Payet MD, Gallo-Payet N, Sarret P, Beaudet A.

Mol Pharmacol. 2004 Dec;66(6):1421-30. Epub 2004 Sep 10.

PMID:
15361549
17.

Novel neurotensin analogues for radioisotope targeting to neurotensin receptor-positive tumors.

Alshoukr F, Rosant C, Maes V, Abdelhak J, Raguin O, Burg S, Sarda L, Barbet J, Tourwé D, Pelaprat D, Gruaz-Guyon A.

Bioconjug Chem. 2009 Aug 19;20(8):1602-10. doi: 10.1021/bc900151z. Epub 2009 Jul 17.

PMID:
19610615
18.

Radical arylation of tyrosine and its application in the synthesis of a highly selective neurotensin receptor 2 ligand.

Pratsch G, Unfried JF, Einsiedel J, Plomer M, Hübner H, Gmeiner P, Heinrich MR.

Org Biomol Chem. 2011 May 21;9(10):3746-52. doi: 10.1039/c1ob05292f. Epub 2011 Apr 6.

PMID:
21472182
19.

[Synthesis and biological activity of cyclic and linear analogs of C-terminal fragments of neurotensin].

Grinshteĭne IV, Misinia IP, Vegner RE, Vosekalna IA, Gaĭlite EA.

Bioorg Khim. 1985 Sep;11(9):1167-79. Russian.

PMID:
4062994
20.

Emerging role of neurotensin in regulation of the cardiovascular system.

Osadchii OE.

Eur J Pharmacol. 2015 Sep 5;762:184-92. doi: 10.1016/j.ejphar.2015.05.025. Epub 2015 May 21. Review.

PMID:
26004530

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