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Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration.

Khiati S, Baechler SA, Factor VM, Zhang H, Huang SY, Dalla Rosa I, Sourbier C, Neckers L, Thorgeirsson SS, Pommier Y.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11282-7. doi: 10.1073/pnas.1511016112. Epub 2015 Aug 24.


Mapping topoisomerase sites in mitochondrial DNA with a poisonous mitochondrial topoisomerase I (Top1mt).

Dalla Rosa I, Huang SY, Agama K, Khiati S, Zhang H, Pommier Y.

J Biol Chem. 2014 Jun 27;289(26):18595-602. doi: 10.1074/jbc.M114.555367. Epub 2014 May 5.


The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis.

Baechler SA, Factor VM, Dalla Rosa I, Ravji A, Becker D, Khiati S, Miller Jenkins LM, Lang M, Sourbier C, Michaels SA, Neckers LM, Zhang HL, Spinazzola A, Huang SN, Marquardt JU, Pommier Y.

Nat Commun. 2019 Jan 8;10(1):83. doi: 10.1038/s41467-018-07922-3.


Mitochondrial topoisomerase I (top1mt) is a novel limiting factor of doxorubicin cardiotoxicity.

Khiati S, Dalla Rosa I, Sourbier C, Ma X, Rao VA, Neckers LM, Zhang H, Pommier Y.

Clin Cancer Res. 2014 Sep 15;20(18):4873-81. doi: 10.1158/1078-0432.CCR-13-3373. Epub 2014 Apr 8.


Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism.

Douarre C, Sourbier C, Dalla Rosa I, Brata Das B, Redon CE, Zhang H, Neckers L, Pommier Y.

PLoS One. 2012;7(7):e41094. doi: 10.1371/journal.pone.0041094. Epub 2012 Jul 20.


Transcription profiling suggests that mitochondrial topoisomerase IB acts as a topological barrier and regulator of mitochondrial DNA transcription.

Dalla Rosa I, Zhang H, Khiati S, Wu X, Pommier Y.

J Biol Chem. 2017 Dec 8;292(49):20162-20172. doi: 10.1074/jbc.M117.815241. Epub 2017 Oct 11.


Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria.

Zhang H, Zhang YW, Yasukawa T, Dalla Rosa I, Khiati S, Pommier Y.

Nucleic Acids Res. 2014 Jun;42(11):7259-67. doi: 10.1093/nar/gku384. Epub 2014 May 6.


Poisoning of mitochondrial topoisomerase I by lamellarin D.

Khiati S, Seol Y, Agama K, Dalla Rosa I, Agrawal S, Fesen K, Zhang H, Neuman KC, Pommier Y.

Mol Pharmacol. 2014 Aug;86(2):193-9. doi: 10.1124/mol.114.092833. Epub 2014 Jun 2.


Mitochondrial topoisomerase I sites in the regulatory D-loop region of mitochondrial DNA.

Zhang H, Pommier Y.

Biochemistry. 2008 Oct 28;47(43):11196-203. doi: 10.1021/bi800774b. Epub 2008 Oct 1.


Deceleration of liver regeneration by knockdown of augmenter of liver regeneration gene is associated with impairment of mitochondrial DNA synthesis in mice.

Han LH, Dong LY, Yu H, Sun GY, Wu Y, Gao J, Thasler W, An W.

Am J Physiol Gastrointest Liver Physiol. 2015 Jul 15;309(2):G112-22. doi: 10.1152/ajpgi.00435.2014. Epub 2015 May 14.


Prolonged exposure to insulin suppresses mitochondrial production in primary hepatocytes.

Liu HY, Yehuda-Shnaidman E, Hong T, Han J, Pi J, Liu Z, Cao W.

J Biol Chem. 2009 May 22;284(21):14087-95. doi: 10.1074/jbc.M807992200. Epub 2009 Mar 31.


Mitochondrial topoisomerases and alternative splicing of the human TOP1mt gene.

Zhang H, Meng LH, Pommier Y.

Biochimie. 2007 Apr;89(4):474-81. Epub 2006 Nov 27. Review.


Human mitochondrial topoisomerase I.

Zhang H, Barceló JM, Lee B, Kohlhagen G, Zimonjic DB, Popescu NC, Pommier Y.

Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10608-13. Epub 2001 Aug 28.


Coordinated regulation of mitochondrial topoisomerase IB with mitochondrial nuclear encoded genes and MYC.

Zoppoli G, Douarre C, Dalla Rosa I, Liu H, Reinhold W, Pommier Y.

Nucleic Acids Res. 2011 Aug;39(15):6620-32. doi: 10.1093/nar/gkr208. Epub 2011 Apr 29.


Role for the endoplasmic reticulum stress sensor IRE1α in liver regenerative responses.

Liu Y, Shao M, Wu Y, Yan C, Jiang S, Liu J, Dai J, Yang L, Li J, Jia W, Rui L, Liu Y.

J Hepatol. 2015 Mar;62(3):590-8. doi: 10.1016/j.jhep.2014.10.022. Epub 2014 Oct 22.


The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species.

Siegmund SV, Qian T, de Minicis S, Harvey-White J, Kunos G, Vinod KY, Hungund B, Schwabe RF.

FASEB J. 2007 Sep;21(11):2798-806. Epub 2007 Apr 17.


Interleukin-1 receptor antagonist modulates the early phase of liver regeneration after partial hepatectomy in mice.

Sgroi A, Gonelle-Gispert C, Morel P, Baertschiger RM, Niclauss N, Mentha G, Majno P, Serre-Beinier V, Buhler L.

PLoS One. 2011;6(9):e25442. doi: 10.1371/journal.pone.0025442. Epub 2011 Sep 27.


Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice.

Scheving LA, Zhang X, Stevenson MC, Threadgill DW, Russell WE.

Am J Physiol Gastrointest Liver Physiol. 2015 Mar 1;308(5):G364-77. doi: 10.1152/ajpgi.00364.2014. Epub 2014 Nov 20.


Rapid and random turnover of mitochondrial DNA in rat hepatocytes of primary culture.

Kai Y, Takamatsu C, Tokuda K, Okamoto M, Irita K, Takahashi S.

Mitochondrion. 2006 Dec;6(6):299-304. Epub 2006 Oct 17.


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