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Items: 1 to 20 of 242

1.

RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.

Ohshima J, Sasai M, Liu J, Yamashita K, Ma JS, Lee Y, Bando H, Howard JC, Ebisu S, Hayashi M, Takeda K, Standley DM, Frickel EM, Yamamoto M.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4581-90. doi: 10.1073/pnas.1510031112. Epub 2015 Aug 3.

2.

Role of mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii.

Ohshima J, Lee Y, Sasai M, Saitoh T, Su Ma J, Kamiyama N, Matsuura Y, Pann-Ghill S, Hayashi M, Ebisu S, Takeda K, Akira S, Yamamoto M.

J Immunol. 2014 Apr 1;192(7):3328-35. doi: 10.4049/jimmunol.1302822. Epub 2014 Feb 21.

3.

A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii.

Yamamoto M, Okuyama M, Ma JS, Kimura T, Kamiyama N, Saiga H, Ohshima J, Sasai M, Kayama H, Okamoto T, Huang DC, Soldati-Favre D, Horie K, Takeda J, Takeda K.

Immunity. 2012 Aug 24;37(2):302-13. Epub 2012 Jul 12.

4.

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens.

Liesenfeld O, Parvanova I, Zerrahn J, Han SJ, Heinrich F, Muñoz M, Kaiser F, Aebischer T, Buch T, Waisman A, Reichmann G, Utermöhlen O, von Stebut E, von Loewenich FD, Bogdan C, Specht S, Saeftel M, Hoerauf A, Mota MM, Könen-Waisman S, Kaufmann SH, Howard JC.

PLoS One. 2011;6(6):e20568. doi: 10.1371/journal.pone.0020568. Epub 2011 Jun 17.

5.

The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii.

Pawlowski N, Khaminets A, Hunn JP, Papic N, Schmidt A, Uthaiah RC, Lange R, Vopper G, Martens S, Wolf E, Howard JC.

BMC Biol. 2011 Jan 28;9:7. doi: 10.1186/1741-7007-9-7.

6.
7.

Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.

Martens S, Parvanova I, Zerrahn J, Griffiths G, Schell G, Reichmann G, Howard JC.

PLoS Pathog. 2005 Nov;1(3):e24. Epub 2005 Nov 18.

8.

Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii.

Selleck EM, Fentress SJ, Beatty WL, Degrandi D, Pfeffer K, Virgin HW 4th, Macmicking JD, Sibley LD.

PLoS Pathog. 2013;9(4):e1003320. doi: 10.1371/journal.ppat.1003320. Epub 2013 Apr 25.

9.

In astrocytes the accumulation of the immunity-related GTPases Irga6 and Irgb6 at the vacuole of Toxoplasma gondii is dependent on the parasite virulence.

Lubitz FP, Degrandi D, Pfeffer K, Mausberg AK.

ScientificWorldJournal. 2013 Nov 12;2013:480231. doi: 10.1155/2013/480231. eCollection 2013.

10.

The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii.

Kravets E, Degrandi D, Weidtkamp-Peters S, Ries B, Konermann C, Felekyan S, Dargazanli JM, Praefcke GJ, Seidel CA, Schmitt L, Smits SH, Pfeffer K.

J Biol Chem. 2012 Aug 10;287(33):27452-66. doi: 10.1074/jbc.M112.379636. Epub 2012 Jun 22.

11.

Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it.

Virreira Winter S, Niedelman W, Jensen KD, Rosowski EE, Julien L, Spooner E, Caradonna K, Burleigh BA, Saeij JP, Ploegh HL, Frickel EM.

PLoS One. 2011;6(9):e24434. doi: 10.1371/journal.pone.0024434. Epub 2011 Sep 8.

12.
13.

The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.

Haldar AK, Piro AS, Pilla DM, Yamamoto M, Coers J.

PLoS One. 2014 Jan 17;9(1):e86684. doi: 10.1371/journal.pone.0086684. eCollection 2014.

14.

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells.

Selleck EM, Orchard RC, Lassen KG, Beatty WL, Xavier RJ, Levine B, Virgin HW, Sibley LD.

MBio. 2015 Sep 8;6(5):e01157-15. doi: 10.1128/mBio.01157-15.

15.

Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii.

Steinfeldt T, Könen-Waisman S, Tong L, Pawlowski N, Lamkemeyer T, Sibley LD, Hunn JP, Howard JC.

PLoS Biol. 2010 Dec 21;8(12):e1000576. doi: 10.1371/journal.pbio.1000576. Erratum in: PLoS Biol. 2015 Jul;13(7):e1002199.

17.

Inactive and active states of the interferon-inducible resistance GTPase, Irga6, in vivo.

Papic N, Hunn JP, Pawlowski N, Zerrahn J, Howard JC.

J Biol Chem. 2008 Nov 14;283(46):32143-51. doi: 10.1074/jbc.M804846200. Epub 2008 Sep 10.

18.

Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse.

Alaganan A, Fentress SJ, Tang K, Wang Q, Sibley LD.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1126-31. doi: 10.1073/pnas.1313501111. Epub 2014 Jan 3.

19.

Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens.

Zhao Z, Fux B, Goodwin M, Dunay IR, Strong D, Miller BC, Cadwell K, Delgado MA, Ponpuak M, Green KG, Schmidt RE, Mizushima N, Deretic V, Sibley LD, Virgin HW.

Cell Host Microbe. 2008 Nov 13;4(5):458-69. doi: 10.1016/j.chom.2008.10.003.

20.

Antimicrobial effects of murine mesenchymal stromal cells directed against Toxoplasma gondii and Neospora caninum: role of immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs).

Spekker K, Leineweber M, Degrandi D, Ince V, Brunder S, Schmidt SK, Stuhlsatz S, Howard JC, Schares G, Degistirici O, Meisel R, Sorg RV, Seissler J, Hemphill A, Pfeffer K, Däubener W.

Med Microbiol Immunol. 2013 Jun;202(3):197-206. doi: 10.1007/s00430-012-0281-y. Epub 2012 Dec 27.

PMID:
23269418

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