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Items: 1 to 20 of 88

1.

β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis.

Smith LK, He Y, Park JS, Bieri G, Snethlage CE, Lin K, Gontier G, Wabl R, Plambeck KE, Udeochu J, Wheatley EG, Bouchard J, Eggel A, Narasimha R, Grant JL, Luo J, Wyss-Coray T, Villeda SA.

Nat Med. 2015 Aug;21(8):932-7. doi: 10.1038/nm.3898. Epub 2015 Jul 6.

2.

Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal.

Yousef H, Conboy MJ, Morgenthaler A, Schlesinger C, Bugaj L, Paliwal P, Greer C, Conboy IM, Schaffer D.

Oncotarget. 2015 May 20;6(14):11959-78.

3.

The ageing systemic milieu negatively regulates neurogenesis and cognitive function.

Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Després S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T.

Nature. 2011 Aug 31;477(7362):90-4. doi: 10.1038/nature10357.

4.

Differential reactivity of residual CD8+ T lymphocytes in TAP1 and beta 2-microglobulin mutant mice.

Ljunggren HG, Van Kaer L, Ashton-Rickardt PG, Tonegawa S, Ploegh HL.

Eur J Immunol. 1995 Jan;25(1):174-8.

PMID:
7843229
5.

Adult neurogenesis is unaffected by a functional knock-out of MHC class I in mice.

Laguna Goya R, Tyers P, Barker RA.

Neuroreport. 2010 Mar 31;21(5):349-53. doi: 10.1097/WNR.0b013e3283377463.

PMID:
20147861
6.

Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain.

Gontier G, Iyer M, Shea JM, Bieri G, Wheatley EG, Ramalho-Santos M, Villeda SA.

Cell Rep. 2018 Feb 20;22(8):1974-1981. doi: 10.1016/j.celrep.2018.02.001.

7.

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.

Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo FM, Wyss-Coray T.

Nat Med. 2014 Jun;20(6):659-63. doi: 10.1038/nm.3569. Epub 2014 May 4.

8.

MHC class I immune proteins are critical for hippocampus-dependent memory and gate NMDAR-dependent hippocampal long-term depression.

Nelson PA, Sage JR, Wood SC, Davenport CM, Anagnostaras SG, Boulanger LM.

Learn Mem. 2013 Sep 1;20(9):505-17. doi: 10.1101/lm.031351.113.

10.

The circulatory systemic environment as a modulator of neurogenesis and brain aging.

Villeda SA, Wyss-Coray T.

Autoimmun Rev. 2013 Apr;12(6):674-7. doi: 10.1016/j.autrev.2012.10.014. Epub 2012 Nov 29. Review.

PMID:
23201925
11.

Expression of antigen processing and presenting molecules in brain metastasis of breast cancer.

Liu Y, Komohara Y, Domenick N, Ohno M, Ikeura M, Hamilton RL, Horbinski C, Wang X, Ferrone S, Okada H.

Cancer Immunol Immunother. 2012 Jun;61(6):789-801. doi: 10.1007/s00262-011-1137-9. Epub 2011 Nov 8.

12.

Targeted Disruption of the β2-Microglobulin Gene Minimizes the Immunogenicity of Human Embryonic Stem Cells.

Wang D, Quan Y, Yan Q, Morales JE, Wetsel RA.

Stem Cells Transl Med. 2015 Oct;4(10):1234-45. doi: 10.5966/sctm.2015-0049. Epub 2015 Aug 18.

13.

Breaking bad blood: β2-microglobulin as a pro-aging factor in blood.

Filiano AJ, Kipnis J.

Nat Med. 2015 Aug;21(8):844-5. doi: 10.1038/nm.3926. No abstract available.

PMID:
26248266
14.

Effect of B2m gene disruption on MHC-determined odortypes.

Bard J, Yamazaki K, Curran M, Boyse EA, Beauchamp GK.

Immunogenetics. 2000 Jun;51(7):514-8.

PMID:
10912502
16.

MHC class I-deficient metastatic tumor variants immunoselected by T lymphocytes originate from the coordinated downregulation of APM components.

Garcia-Lora A, Martinez M, Algarra I, Gaforio JJ, Garrido F.

Int J Cancer. 2003 Sep 10;106(4):521-7.

17.

Hippocampal β2‑microglobulin mediates sepsis‑induced cognitive impairment.

Gao R, Li G, Yang R, Yuan H, Zhang S.

Mol Med Rep. 2018 Jun;17(6):7813-7820. doi: 10.3892/mmr.2018.8858. Epub 2018 Apr 5.

PMID:
29620245
18.

Development of CD8 alpha alpha+ intestinal intraepithelial T cells in beta 2-microglobulin- and/or TAP1-deficient mice.

Fujiura Y, Kawaguchi M, Kondo Y, Obana S, Yamamoto H, Nanno M, Ishikawa H.

J Immunol. 1996 Apr 15;156(8):2710-5.

PMID:
8609387
19.

The systemic environment: at the interface of aging and adult neurogenesis.

Smith LK, White CW 3rd, Villeda SA.

Cell Tissue Res. 2018 Jan;371(1):105-113. doi: 10.1007/s00441-017-2715-8. Epub 2017 Nov 9. Review.

20.

Maturation of Qa-1b class I molecules requires beta 2-microglobulin but is TAP independent.

Robinson PJ, Travers PJ, Stackpoole A, Flaherty L, Djaballah H.

J Immunol. 1998 Apr 1;160(7):3217-24.

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