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Items: 1 to 20 of 111

1.

Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein.

Ehrlich M, Hallmann AL, Reinhardt P, Araúzo-Bravo MJ, Korr S, Röpke A, Psathaki OE, Ehling P, Meuth SG, Oblak AL, Murrell JR, Ghetti B, Zaehres H, Schöler HR, Sterneckert J, Kuhlmann T, Hargus G.

Stem Cell Reports. 2015 Jul 14;5(1):83-96. doi: 10.1016/j.stemcr.2015.06.001. Epub 2015 Jul 2.

2.

MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations.

Biswas MHU, Almeida S, Lopez-Gonzalez R, Mao W, Zhang Z, Karydas A, Geschwind MD, Biernat J, Mandelkow EM, Futai K, Miller BL, Gao FB.

Stem Cell Reports. 2016 Sep 13;7(3):316-324. doi: 10.1016/j.stemcr.2016.08.006. Epub 2016 Sep 1.

3.

Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein.

Hallmann AL, Araúzo-Bravo MJ, Mavrommatis L, Ehrlich M, Röpke A, Brockhaus J, Missler M, Sterneckert J, Schöler HR, Kuhlmann T, Zaehres H, Hargus G.

Sci Rep. 2017 Mar 3;7:42991. doi: 10.1038/srep42991.

4.

Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells.

Wren MC, Zhao J, Liu CC, Murray ME, Atagi Y, Davis MD, Fu Y, Okano HJ, Ogaki K, Strongosky AJ, Tacik P, Rademakers R, Ross OA, Dickson DW, Wszolek ZK, Kanekiyo T, Bu G.

Mol Neurodegener. 2015 Sep 15;10:46. doi: 10.1186/s13024-015-0042-7.

5.

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.

Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MHU, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, Steen JA, Haggarty SJ.

Stem Cell Reports. 2016 Sep 13;7(3):325-340. doi: 10.1016/j.stemcr.2016.08.001. Epub 2016 Sep 1.

6.

Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration.

Esteras N, Rohrer JD, Hardy J, Wray S, Abramov AY.

Redox Biol. 2017 Aug;12:410-422. doi: 10.1016/j.redox.2017.03.008. Epub 2017 Mar 10.

7.

Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a P301L mutation in microtubule-associated protein tau (MAPT).

Rasmussen MA, Hjermind LE, Hasholt LF, Waldemar G, Nielsen JE, Clausen C, Hyttel P, Holst B.

Stem Cell Res. 2016 Jan;16(1):70-4. doi: 10.1016/j.scr.2015.12.008. Epub 2015 Dec 12.

8.

Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia.

Nimsanor N, Jørring I, Rasmussen MA, Clausen C, Mau-Holzmann UA, Kitiyanant N, Nielsen JE, Nielsen TT, Hyttel P, Holst B, Schmid B.

Stem Cell Res. 2016 Nov;17(3):564-567. doi: 10.1016/j.scr.2016.10.006. Epub 2016 Oct 20.

9.

Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene.

Nimsanor N, Poulsen U, Rasmussen MA, Clausen C, Mau-Holzmann UA, Nielsen JE, Nielsen TT, Hyttel P, Holst B, Schmid B.

Stem Cell Res. 2016 Nov;17(3):576-579. doi: 10.1016/j.scr.2016.09.020. Epub 2016 Sep 28.

10.

Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.

Sposito T, Preza E, Mahoney CJ, Setó-Salvia N, Ryan NS, Morris HR, Arber C, Devine MJ, Houlden H, Warner TT, Bushell TJ, Zagnoni M, Kunath T, Livesey FJ, Fox NC, Rossor MN, Hardy J, Wray S.

Hum Mol Genet. 2015 Sep 15;24(18):5260-9. doi: 10.1093/hmg/ddv246. Epub 2015 Jul 1.

11.

Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B.

Zhang Y, Schmid B, Nikolaisen NK, Rasmussen MA, Aldana BI, Agger M, Calloe K, Stummann TC, Larsen HM, Nielsen TT, Huang J, Xu F, Liu X, Bolund L, Meyer M, Bak LK, Waagepetersen HS, Luo Y, Nielsen JE; FReJA Consortium, Holst B, Clausen C, Hyttel P, Freude KK.

Stem Cell Reports. 2017 Mar 14;8(3):648-658. doi: 10.1016/j.stemcr.2017.01.012. Epub 2017 Feb 16.

12.

Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.

Iovino M, Agathou S, González-Rueda A, Del Castillo Velasco-Herrera M, Borroni B, Alberici A, Lynch T, O'Dowd S, Geti I, Gaffney D, Vallier L, Paulsen O, Káradóttir RT, Spillantini MG.

Brain. 2015 Nov;138(Pt 11):3345-59. doi: 10.1093/brain/awv222. Epub 2015 Jul 27.

13.

Induced pluripotent stem cells (iPSCs) derived from a pre-symptomatic carrier of a R406W mutation in microtubule-associated protein tau (MAPT) causing frontotemporal dementia.

Rasmussen MA, Hjermind LE, Hasholt LF, Waldemar G, Nielsen JE, Clausen C, Hyttel P, Holst B.

Stem Cell Res. 2016 Jan;16(1):105-9. doi: 10.1016/j.scr.2015.12.012. Epub 2015 Dec 23.

14.

Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration.

García-León JA, Cabrera-Socorro A, Eggermont K, Swijsen A, Terryn J, Fazal R, Nami F, Ordovás L, Quiles A, Lluis F, Serneels L, Wierda K, Sierksma A, Kreir M, Pestana F, Van Damme P, De Strooper B, Thorrez L, Ebneth A, Verfaillie CM.

Alzheimers Dement. 2018 Oct;14(10):1261-1280. doi: 10.1016/j.jalz.2018.05.007. Epub 2018 Jul 20.

15.

Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene.

Nimsanor N, Kitiyanant N, Poulsen U, Rasmussen MA, Clausen C, Mau-Holzmann UA, Nielsen JE, Nielsen TT, Hyttel P, Holst B, Schmid B.

Stem Cell Res. 2016 Nov;17(3):556-559. doi: 10.1016/j.scr.2016.09.021. Epub 2016 Sep 28.

16.

Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT).

Rasmussen MA, Hjermind LE, Hasholt LF, Waldemar G, Nielsen JE, Clausen C, Hyttel P, Holst B.

Stem Cell Res. 2016 Jan;16(1):75-8. doi: 10.1016/j.scr.2015.12.006. Epub 2015 Dec 12.

17.

Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia.

Raitano S, Ordovàs L, De Muynck L, Guo W, Espuny-Camacho I, Geraerts M, Khurana S, Vanuytsel K, Tóth BI, Voets T, Vandenberghe R, Cathomen T, Van Den Bosch L, Vanderhaeghen P, Van Damme P, Verfaillie CM.

Stem Cell Reports. 2015 Jan 13;4(1):16-24. doi: 10.1016/j.stemcr.2014.12.001. Epub 2014 Dec 31.

18.

Microtubule-associated protein tau genetic variations are uncommon cause of frontotemporal dementia in south India.

Aswathy PM, Jairani PS, Verghese J, Gopala S, Mathuranath PS.

Neurobiol Aging. 2014 Feb;35(2):443.e23-4. doi: 10.1016/j.neurobiolaging.2013.08.010. Epub 2013 Sep 13.

19.

Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP.

Jiang S, Wen N, Li Z, Dube U, Del Aguila J, Budde J, Martinez R, Hsu S, Fernandez MV, Cairns NJ; Dominantly Inherited Alzheimer Network (DIAN); International FTD-Genomics Consortium (IFGC), Harari O, Cruchaga C, Karch CM.

Transl Psychiatry. 2018 Dec 13;8(1):265. doi: 10.1038/s41398-018-0319-z.

20.

Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs.

Nakamura M, Shiozawa S, Tsuboi D, Amano M, Watanabe H, Maeda S, Kimura T, Yoshimatsu S, Kisa F, Karch CM, Miyasaka T, Takashima A, Sahara N, Hisanaga SI, Ikeuchi T, Kaibuchi K, Okano H.

Stem Cell Reports. 2019 Oct 8;13(4):684-699. doi: 10.1016/j.stemcr.2019.08.011. Epub 2019 Sep 19.

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