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Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining.

Kukshal V, Kim IK, Hura GL, Tomkinson AE, Tainer JA, Ellenberger T.

Nucleic Acids Res. 2015 Aug 18;43(14):7021-31. doi: 10.1093/nar/gkv652. Epub 2015 Jun 29.


DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells.

Oh S, Harvey A, Zimbric J, Wang Y, Nguyen T, Jackson PJ, Hendrickson EA.

DNA Repair (Amst). 2014 Sep;21:97-110. doi: 10.1016/j.dnarep.2014.04.015. Epub 2014 May 16.


Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells.

Arakawa H, Bednar T, Wang M, Paul K, Mladenov E, Bencsik-Theilen AA, Iliakis G.

Nucleic Acids Res. 2012 Mar;40(6):2599-610. doi: 10.1093/nar/gkr1024. Epub 2011 Nov 29.


Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states.

Cotner-Gohara E, Kim IK, Hammel M, Tainer JA, Tomkinson AE, Ellenberger T.

Biochemistry. 2010 Jul 27;49(29):6165-76. doi: 10.1021/bi100503w.


Structure and function of the DNA ligases encoded by the mammalian LIG3 gene.

Tomkinson AE, Sallmyr A.

Gene. 2013 Dec 1;531(2):150-7. doi: 10.1016/j.gene.2013.08.061. Epub 2013 Sep 5. Review.


Two DNA-binding and nick recognition modules in human DNA ligase III.

Cotner-Gohara E, Kim IK, Tomkinson AE, Ellenberger T.

J Biol Chem. 2008 Apr 18;283(16):10764-72. doi: 10.1074/jbc.M708175200. Epub 2008 Jan 30.


Human DNA ligase I completely encircles and partially unwinds nicked DNA.

Pascal JM, O'Brien PJ, Tomkinson AE, Ellenberger T.

Nature. 2004 Nov 25;432(7016):473-8.


C-Terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin.

Liu S, Liu X, Kamdar RP, Wanotayan R, Sharma MK, Adachi N, Matsumoto Y.

Biochem Biophys Res Commun. 2013 Sep 20;439(2):173-8. doi: 10.1016/j.bbrc.2013.08.068. Epub 2013 Aug 28.


Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase.

Chen L, Trujillo K, Sung P, Tomkinson AE.

J Biol Chem. 2000 Aug 25;275(34):26196-205.


The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends.

Aniukwu J, Glickman MS, Shuman S.

Genes Dev. 2008 Feb 15;22(4):512-27. doi: 10.1101/gad.1631908.


Biochemical evidence for Ku-independent backup pathways of NHEJ.

Wang H, Perrault AR, Takeda Y, Qin W, Wang H, Iliakis G.

Nucleic Acids Res. 2003 Sep 15;31(18):5377-88.


Role of the DNA ligase III zinc finger in polynucleotide binding and ligation.

Taylor RM, Whitehouse J, Cappelli E, Frosina G, Caldecott KW.

Nucleic Acids Res. 1998 Nov 1;26(21):4804-10.


Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair.

Chen X, Ballin JD, Della-Maria J, Tsai MS, White EJ, Tomkinson AE, Wilson GM.

DNA Repair (Amst). 2009 Aug 6;8(8):961-8. doi: 10.1016/j.dnarep.2009.06.002. Epub 2009 Jul 8.


Two-Stage Synapsis of DNA Ends during Non-homologous End Joining.

Graham TG, Walter JC, Loparo JJ.

Mol Cell. 2016 Mar 17;61(6):850-8. doi: 10.1016/j.molcel.2016.02.010.


Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining.

Lu G, Duan J, Shu S, Wang X, Gao L, Guo J, Zhang Y.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1256-60. doi: 10.1073/pnas.1521597113. Epub 2016 Jan 19.


Ku recruits the XRCC4-ligase IV complex to DNA ends.

Nick McElhinny SA, Snowden CM, McCarville J, Ramsden DA.

Mol Cell Biol. 2000 May;20(9):2996-3003.


Pol I DNA polymerases stimulate DNA end-joining by Escherichia coli DNA ligase.

Yang Y, LiCata VJ.

Biochem Biophys Res Commun. 2018 Feb 26;497(1):13-18. doi: 10.1016/j.bbrc.2018.01.165. Epub 2018 Jan 31.


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