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Items: 1 to 20 of 112

1.

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart.

Kwong JQ, Lu X, Correll RN, Schwanekamp JA, Vagnozzi RJ, Sargent MA, York AJ, Zhang J, Bers DM, Molkentin JD.

Cell Rep. 2015 Jul 7;12(1):15-22. doi: 10.1016/j.celrep.2015.06.002. Epub 2015 Jun 25.

2.

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition.

Luongo TS, Lambert JP, Yuan A, Zhang X, Gross P, Song J, Shanmughapriya S, Gao E, Jain M, Houser SR, Koch WJ, Cheung JY, Madesh M, Elrod JW.

Cell Rep. 2015 Jul 7;12(1):23-34. doi: 10.1016/j.celrep.2015.06.017. Epub 2015 Jun 25.

3.

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.

Rasmussen TP, Wu Y, Joiner ML, Koval OM, Wilson NR, Luczak ED, Wang Q, Chen B, Gao Z, Zhu Z, Wagner BA, Soto J, McCormick ML, Kutschke W, Weiss RM, Yu L, Boudreau RL, Abel ED, Zhan F, Spitz DR, Buettner GR, Song LS, Zingman LV, Anderson ME.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9129-34. doi: 10.1073/pnas.1504705112. Epub 2015 Jul 7.

4.

Expression of the mitochondrial calcium uniporter in cardiac myocytes improves impaired mitochondrial calcium handling and metabolism in simulated hyperglycemia.

Diaz-Juarez J, Suarez J, Cividini F, Scott BT, Diemer T, Dai A, Dillmann WH.

Am J Physiol Cell Physiol. 2016 Dec 1;311(6):C1005-C1013. doi: 10.1152/ajpcell.00236.2016. Epub 2016 Sep 28.

5.

Restoring mitochondrial calcium uniporter expression in diabetic mouse heart improves mitochondrial calcium handling and cardiac function.

Suarez J, Cividini F, Scott BT, Lehmann K, Diaz-Juarez J, Diemer T, Dai A, Suarez JA, Jain M, Dillmann WH.

J Biol Chem. 2018 May 25;293(21):8182-8195. doi: 10.1074/jbc.RA118.002066. Epub 2018 Apr 6.

6.

Deletion of mitochondrial calcium uniporter incompletely inhibits calcium uptake and induction of the permeability transition pore in brain mitochondria.

Hamilton J, Brustovetsky T, Rysted JE, Lin Z, Usachev YM, Brustovetsky N.

J Biol Chem. 2018 Oct 5;293(40):15652-15663. doi: 10.1074/jbc.RA118.002926. Epub 2018 Aug 28.

7.

Content of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy.

Zaglia T, Ceriotti P, Campo A, Borile G, Armani A, Carullo P, Prando V, Coppini R, Vida V, Stølen TO, Ulrik W, Cerbai E, Stellin G, Faggian G, De Stefani D, Sandri M, Rizzuto R, Di Lisa F, Pozzan T, Catalucci D, Mongillo M.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9006-E9015. doi: 10.1073/pnas.1708772114. Epub 2017 Oct 9.

8.

Small Interfering RNA Targeting Mitochondrial Calcium Uniporter Improves Cardiomyocyte Cell Viability in Hypoxia/Reoxygenation Injury by Reducing Calcium Overload.

Oropeza-Almazán Y, Vázquez-Garza E, Chapoy-Villanueva H, Torre-Amione G, García-Rivas G.

Oxid Med Cell Longev. 2017;2017:5750897. doi: 10.1155/2017/5750897. Epub 2017 Feb 27.

9.

Opening of mitochondrial permeability transition pore induces hypercontracture in Ca2+ overloaded cardiac myocytes.

Ruiz-Meana M, Abellán A, Miró-Casas E, Garcia-Dorado D.

Basic Res Cardiol. 2007 Nov;102(6):542-52. Epub 2007 Sep 24.

PMID:
17891523
10.

Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells.

Quan X, Nguyen TT, Choi SK, Xu S, Das R, Cha SK, Kim N, Han J, Wiederkehr A, Wollheim CB, Park KS.

J Biol Chem. 2015 Feb 13;290(7):4086-96. doi: 10.1074/jbc.M114.632547. Epub 2014 Dec 29.

11.

Global ablation of the mitochondrial calcium uniporter increases glycolysis in cortical neurons subjected to energetic stressors.

Nichols M, Elustondo PA, Warford J, Thirumaran A, Pavlov EV, Robertson GS.

J Cereb Blood Flow Metab. 2017 Aug;37(8):3027-3041. doi: 10.1177/0271678X16682250. Epub 2016 Jan 1.

12.

Impaired expression of the mitochondrial calcium uniporter suppresses mast cell degranulation.

Furuno T, Shinkai N, Inoh Y, Nakanishi M.

Mol Cell Biochem. 2015 Dec;410(1-2):215-21. doi: 10.1007/s11010-015-2554-4. Epub 2015 Sep 8.

PMID:
26350567
13.

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.

Pan X, Liu J, Nguyen T, Liu C, Sun J, Teng Y, Fergusson MM, Rovira II, Allen M, Springer DA, Aponte AM, Gucek M, Balaban RS, Murphy E, Finkel T.

Nat Cell Biol. 2013 Dec;15(12):1464-72. doi: 10.1038/ncb2868. Epub 2013 Nov 10.

14.

Glutamate excitotoxicity and Ca2+-regulation of respiration: Role of the Ca2+ activated mitochondrial transporters (CaMCs).

Rueda CB, Llorente-Folch I, Traba J, Amigo I, Gonzalez-Sanchez P, Contreras L, Juaristi I, Martinez-Valero P, Pardo B, Del Arco A, Satrustegui J.

Biochim Biophys Acta. 2016 Aug;1857(8):1158-1166. doi: 10.1016/j.bbabio.2016.04.003. Epub 2016 Apr 7. Review.

15.

Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter.

O-Uchi J, Jhun BS, Xu S, Hurst S, Raffaello A, Liu X, Yi B, Zhang H, Gross P, Mishra J, Ainbinder A, Kettlewell S, Smith GL, Dirksen RT, Wang W, Rizzuto R, Sheu SS.

Antioxid Redox Signal. 2014 Aug 20;21(6):863-79. doi: 10.1089/ars.2013.5394. Epub 2014 Jun 25.

16.

Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter.

Holmström KM, Pan X, Liu JC, Menazza S, Liu J, Nguyen TT, Pan H, Parks RJ, Anderson S, Noguchi A, Springer D, Murphy E, Finkel T.

J Mol Cell Cardiol. 2015 Aug;85:178-82. doi: 10.1016/j.yjmcc.2015.05.022. Epub 2015 Jun 6.

17.

CaMKII determines mitochondrial stress responses in heart.

Joiner ML, Koval OM, Li J, He BJ, Allamargot C, Gao Z, Luczak ED, Hall DD, Fink BD, Chen B, Yang J, Moore SA, Scholz TD, Strack S, Mohler PJ, Sivitz WI, Song LS, Anderson ME.

Nature. 2012 Nov 8;491(7423):269-73. doi: 10.1038/nature11444. Epub 2012 Oct 10.

18.

The mitochondrial calcium uniporter regulates procoagulant platelet formation.

Kholmukhamedov A, Janecke R, Choo HJ, Jobe SM.

J Thromb Haemost. 2018 Nov;16(11):2315-2321. doi: 10.1111/jth.14284. Epub 2018 Oct 29.

PMID:
30179298
19.

TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria.

Miller BA, Hoffman NE, Merali S, Zhang XQ, Wang J, Rajan S, Shanmughapriya S, Gao E, Barrero CA, Mallilankaraman K, Song J, Gu T, Hirschler-Laszkiewicz I, Koch WJ, Feldman AM, Madesh M, Cheung JY.

J Biol Chem. 2014 Mar 14;289(11):7615-29. doi: 10.1074/jbc.M113.533851. Epub 2014 Feb 3.

20.

Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes.

Drago I, De Stefani D, Rizzuto R, Pozzan T.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12986-91. doi: 10.1073/pnas.1210718109. Epub 2012 Jul 20.

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