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A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis.

Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu FX, Karin M, Pan D, Guan KL.

Genes Dev. 2015 Jun 15;29(12):1271-84. doi: 10.1101/gad.262816.115.


An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2.

Park GS, Oh H, Kim M, Kim T, Johnson RL, Irvine KD, Lim DS.

Oncotarget. 2016 Apr 26;7(17):24063-75. doi: 10.18632/oncotarget.8211.


The Hippo pathway effector proteins YAP and TAZ have both distinct and overlapping functions in the cell.

Plouffe SW, Lin KC, Moore JL 3rd, Tan FE, Ma S, Ye Z, Qiu Y, Ren B, Guan KL.

J Biol Chem. 2018 Jul 13;293(28):11230-11240. doi: 10.1074/jbc.RA118.002715. Epub 2018 May 25.


The Hippo pathway member Nf2 is required for inner cell mass specification.

Cockburn K, Biechele S, Garner J, Rossant J.

Curr Biol. 2013 Jul 8;23(13):1195-201. doi: 10.1016/j.cub.2013.05.044. Epub 2013 Jun 20.


The PDZ-binding motif of Yes-associated protein is required for its co-activation of TEAD-mediated CTGF transcription and oncogenic cell transforming activity.

Shimomura T, Miyamura N, Hata S, Miura R, Hirayama J, Nishina H.

Biochem Biophys Res Commun. 2014 Jan 17;443(3):917-23. doi: 10.1016/j.bbrc.2013.12.100. Epub 2013 Dec 28.


Cysteine S-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ).

Gandhirajan RK, Jain M, Walla B, Johnsen M, Bartram MP, Huynh Anh M, Rinschen MM, Benzing T, Schermer B.

J Biol Chem. 2016 May 27;291(22):11596-607. doi: 10.1074/jbc.M115.712539. Epub 2016 Apr 5.


Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation.

Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan KL.

Nat Cell Biol. 2017 Jul 28;19(8):996-1002. doi: 10.1038/ncb3581. Erratum in: Nat Cell Biol. 2018 Sep;20(9):1098.


Ski regulates Hippo and TAZ signaling to suppress breast cancer progression.

Rashidian J, Le Scolan E, Ji X, Zhu Q, Mulvihill MM, Nomura D, Luo K.

Sci Signal. 2015 Feb 10;8(363):ra14. doi: 10.1126/scisignal.2005735.


Sphingosylphosphorylcholine regulates the Hippo signaling pathway in a dual manner.

Kemppainen K, Wentus N, Lassila T, Laiho A, Törnquist K.

Cell Signal. 2016 Dec;28(12):1894-1903. doi: 10.1016/j.cellsig.2016.09.004. Epub 2016 Sep 12.


YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis.

Cho H, Kim J, Ahn JH, Hong YK, Mäkinen T, Lim DS, Koh GY.

Circ Res. 2019 Jan 18;124(2):225-242. doi: 10.1161/CIRCRESAHA.118.313707.


The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number.

Lavado A, Park JY, Paré J, Finkelstein D, Pan H, Xu B, Fan Y, Kumar RP, Neale G, Kwak YD, McKinnon PJ, Johnson RL, Cao X.

Dev Cell. 2018 Dec 3;47(5):576-591.e8. doi: 10.1016/j.devcel.2018.09.021. Epub 2018 Oct 25.


Transcriptional co-repressor function of the hippo pathway transducers YAP and TAZ.

Kim M, Kim T, Johnson RL, Lim DS.

Cell Rep. 2015 Apr 14;11(2):270-82. doi: 10.1016/j.celrep.2015.03.015. Epub 2015 Apr 2.


Proliferation of hepatic stellate cells, mediated by YAP and TAZ, contributes to liver repair and regeneration after liver ischemia-reperfusion injury.

Konishi T, Schuster RM, Lentsch AB.

Am J Physiol Gastrointest Liver Physiol. 2018 Apr 1;314(4):G471-G482. doi: 10.1152/ajpgi.00153.2017. Epub 2018 Jan 11.


Arsenic-induced cutaneous hyperplastic lesions are associated with the dysregulation of Yap, a Hippo signaling-related protein.

Li C, Srivastava RK, Elmets CA, Afaq F, Athar M.

Biochem Biophys Res Commun. 2013 Sep 6;438(4):607-12. doi: 10.1016/j.bbrc.2013.08.008. Epub 2013 Aug 11.


The Hippo pathway effectors TAZ/YAP regulate dicer expression and microRNA biogenesis through Let-7.

Chaulk SG, Lattanzi VJ, Hiemer SE, Fahlman RP, Varelas X.

J Biol Chem. 2014 Jan 24;289(4):1886-91. doi: 10.1074/jbc.C113.529362. Epub 2013 Dec 9.


The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1.

Hansen CG, Ng YL, Lam WL, Plouffe SW, Guan KL.

Cell Res. 2015 Dec;25(12):1299-313. doi: 10.1038/cr.2015.140. Epub 2015 Nov 27.


A feed forward loop enforces YAP/TAZ signaling during tumorigenesis.

Gill MK, Christova T, Zhang YY, Gregorieff A, Zhang L, Narimatsu M, Song S, Xiong S, Couzens AL, Tong J, Krieger JR, Moran MF, Zlotta AR, van der Kwast TH, Gingras AC, Sicheri F, Wrana JL, Attisano L.

Nat Commun. 2018 Aug 29;9(1):3510. doi: 10.1038/s41467-018-05939-2.


β1 integrin-dependent Rac/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2/merlin.

Sabra H, Brunner M, Mandati V, Wehrle-Haller B, Lallemand D, Ribba AS, Chevalier G, Guardiola P, Block MR, Bouvard D.

J Biol Chem. 2017 Nov 24;292(47):19179-19197. doi: 10.1074/jbc.M117.808063. Epub 2017 Sep 29.


Upregulation of miR-181c contributes to chemoresistance in pancreatic cancer by inactivating the Hippo signaling pathway.

Chen M, Wang M, Xu S, Guo X, Jiang J.

Oncotarget. 2015 Dec 29;6(42):44466-79. doi: 10.18632/oncotarget.6298.


The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment.

Santucci M, Vignudelli T, Ferrari S, Mor M, Scalvini L, Bolognesi ML, Uliassi E, Costi MP.

J Med Chem. 2015 Jun 25;58(12):4857-73. doi: 10.1021/jm501615v. Epub 2015 Mar 11. Review.


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