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Items: 1 to 20 of 222

1.
2.

Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling.

Wiley M, Sweeney KR, Chan DA, Brown KM, McMurtrey C, Howard EW, Giaccia AJ, Blader IJ.

J Biol Chem. 2010 Aug 27;285(35):26852-60. doi: 10.1074/jbc.M110.147041. Epub 2010 Jun 25.

3.

The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels.

Spear W, Chan D, Coppens I, Johnson RS, Giaccia A, Blader IJ.

Cell Microbiol. 2006 Feb;8(2):339-52.

PMID:
16441443
4.

Forward genetic screening identifies a small molecule that blocks Toxoplasma gondii growth by inhibiting both host- and parasite-encoded kinases.

Brown KM, Suvorova E, Farrell A, McLain A, Dittmar A, Wiley GB, Marth G, Gaffney PM, Gubbels MJ, White M, Blader IJ.

PLoS Pathog. 2014 Jun 12;10(6):e1004180. doi: 10.1371/journal.ppat.1004180. eCollection 2014 Jun.

5.
6.

Dicer mediating the expression of miR-143 and miR-155 regulates hexokinase II associated cellular response to hypoxia.

Yao M, Wang X, Tang Y, Zhang W, Cui B, Liu Q, Xing L.

Am J Physiol Lung Cell Mol Physiol. 2014 Dec 1;307(11):L829-37. doi: 10.1152/ajplung.00081.2014. Epub 2014 Aug 29.

7.

Intracellular pathogen Leishmania donovani activates hypoxia inducible factor-1 by dual mechanism for survival advantage within macrophage.

Singh AK, Mukhopadhyay C, Biswas S, Singh VK, Mukhopadhyay CK.

PLoS One. 2012;7(6):e38489. doi: 10.1371/journal.pone.0038489. Epub 2012 Jun 12.

8.

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death.

Cheung EC, Ludwig RL, Vousden KH.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20491-6. doi: 10.1073/pnas.1206530109. Epub 2012 Nov 26.

9.

Serum response factor regulates immediate early host gene expression in Toxoplasma gondii-infected host cells.

Wiley M, Teygong C, Phelps E, Radke J, Blader IJ.

PLoS One. 2011 Mar 29;6(3):e18335. doi: 10.1371/journal.pone.0018335.

10.

INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells.

Min JW, Kim KI, Kim HA, Kim EK, Noh WC, Jeon HB, Cho DH, Oh JS, Park IC, Hwang SG, Kim JS.

Biochem Biophys Res Commun. 2013 Oct 11;440(1):137-42. doi: 10.1016/j.bbrc.2013.09.041. Epub 2013 Sep 17.

PMID:
24051093
11.

Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose.

Maher JC, Wangpaichitr M, Savaraj N, Kurtoglu M, Lampidis TJ.

Mol Cancer Ther. 2007 Feb;6(2):732-41.

12.

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme.

Wolf A, Agnihotri S, Micallef J, Mukherjee J, Sabha N, Cairns R, Hawkins C, Guha A.

J Exp Med. 2011 Feb 14;208(2):313-26. doi: 10.1084/jem.20101470. Epub 2011 Jan 17.

13.

HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism.

Lambert CM, Roy M, Robitaille GA, Richard DE, Bonnet S.

Cardiovasc Res. 2010 Oct 1;88(1):196-204. doi: 10.1093/cvr/cvq152. Epub 2010 May 24.

PMID:
20498255
14.

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].

Stolze IP, Tian YM, Appelhoff RJ, Turley H, Wykoff CC, Gleadle JM, Ratcliffe PJ.

J Biol Chem. 2004 Oct 8;279(41):42719-25. Epub 2004 Aug 9. Erratum in: J Biol Chem. 2004 Dec 24;279(52):54974.

15.

Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme.

Wolf A, Agnihotri S, Munoz D, Guha A.

Neurobiol Dis. 2011 Oct;44(1):84-91. doi: 10.1016/j.nbd.2011.06.007. Epub 2011 Jun 25.

PMID:
21726646
16.

Regulation of HK2 expression through alterations in CpG methylation of the HK2 promoter during progression of hepatocellular carcinoma.

Lee HG, Kim H, Son T, Jeong Y, Kim SU, Dong SM, Park YN, Lee JD, Lee JM, Park JH.

Oncotarget. 2016 Jul 5;7(27):41798-41810. doi: 10.18632/oncotarget.9723.

17.

SIRT6 regulated nucleosomal occupancy affects Hexokinase 2 expression.

Gupta P, Sheikh T, Sen E.

Exp Cell Res. 2017 Aug 1;357(1):98-106. doi: 10.1016/j.yexcr.2017.05.005. Epub 2017 May 4.

PMID:
28478957
18.

STAT3 regulates glycolysis via targeting hexokinase 2 in hepatocellular carcinoma cells.

Li M, Jin R, Wang W, Zhang T, Sang J, Li N, Han Q, Zhao W, Li C, Liu Z.

Oncotarget. 2017 Apr 11;8(15):24777-24784. doi: 10.18632/oncotarget.15801.

19.

HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms.

Marín-Hernández A, Gallardo-Pérez JC, Ralph SJ, Rodríguez-Enríquez S, Moreno-Sánchez R.

Mini Rev Med Chem. 2009 Aug;9(9):1084-101. Review.

PMID:
19689405
20.

A genome-wide siRNA screen to identify host factors necessary for growth of the parasite Toxoplasma gondii.

Moser LA, Pollard AM, Knoll LJ.

PLoS One. 2013 Jun 28;8(6):e68129. doi: 10.1371/journal.pone.0068129. Print 2013.

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