Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 121

1.

An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion.

Priyadarshini M, Villa SR, Fuller M, Wicksteed B, Mackay CR, Alquier T, Poitout V, Mancebo H, Mirmira RG, Gilchrist A, Layden BT.

Mol Endocrinol. 2015 Jul;29(7):1055-66. doi: 10.1210/me.2015-1007. Epub 2015 Jun 15. Erratum in: Mol Endocrinol. 2016 Jul;30(7):826.

2.

The short-chain fatty acid receptor, FFA2, contributes to gestational glucose homeostasis.

Fuller M, Priyadarshini M, Gibbons SM, Angueira AR, Brodsky M, Hayes MG, Kovatcheva-Datchary P, Bäckhed F, Gilbert JA, Lowe WL Jr, Layden BT.

Am J Physiol Endocrinol Metab. 2015 Nov 15;309(10):E840-51. doi: 10.1152/ajpendo.00171.2015. Epub 2015 Sep 22.

3.

GPR43 Potentiates β-Cell Function in Obesity.

McNelis JC, Lee YS, Mayoral R, van der Kant R, Johnson AM, Wollam J, Olefsky JM.

Diabetes. 2015 Sep;64(9):3203-17. doi: 10.2337/db14-1938. Epub 2015 May 28.

4.

G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1.

Ferdaoussi M, Bergeron V, Zarrouki B, Kolic J, Cantley J, Fielitz J, Olson EN, Prentki M, Biden T, MacDonald PE, Poitout V.

Diabetologia. 2012 Oct;55(10):2682-2692. doi: 10.1007/s00125-012-2650-x. Epub 2012 Jul 22.

5.

Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.

Tang C, Ahmed K, Gille A, Lu S, Gröne HJ, Tunaru S, Offermanns S.

Nat Med. 2015 Feb;21(2):173-7. doi: 10.1038/nm.3779. Epub 2015 Jan 12.

PMID:
25581519
6.

FFAR3 modulates insulin secretion and global gene expression in mouse islets.

Priyadarshini M, Layden BT.

Islets. 2015;7(2):e1045182. doi: 10.1080/19382014.2015.1045182. Epub 2015 Jun 19.

7.

Homology modeling of FFA2 identifies novel agonists that potentiate insulin secretion.

Villa SR, Mishra RK, Zapater JL, Priyadarshini M, Gilchrist A, Mancebo H, Schiltz GE, Layden BT.

J Investig Med. 2017 Dec;65(8):1116-1124. doi: 10.1136/jim-2017-000523. Epub 2017 Aug 7.

8.

Alteration of the glucagon axis in GPR120 (FFAR4) knockout mice: a role for GPR120 in glucagon secretion.

Suckow AT, Polidori D, Yan W, Chon S, Ma JY, Leonard J, Briscoe CP.

J Biol Chem. 2014 May 30;289(22):15751-63. doi: 10.1074/jbc.M114.568683. Epub 2014 Apr 17.

9.

Short chain fatty acids stimulate insulin secretion and reduce apoptosis in mouse and human islets in vitro: Role of free fatty acid receptor 2.

Pingitore A, Gonzalez-Abuin N, Ruz-Maldonado I, Huang GC, Frost G, Persaud SJ.

Diabetes Obes Metab. 2019 Feb;21(2):330-339. doi: 10.1111/dom.13529. Epub 2018 Oct 3.

PMID:
30203438
10.

β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.

Mancini AD, Bertrand G, Vivot K, Carpentier É, Tremblay C, Ghislain J, Bouvier M, Poitout V.

J Biol Chem. 2015 Aug 21;290(34):21131-40. doi: 10.1074/jbc.M115.644450. Epub 2015 Jul 8.

11.

Uncoupling protein 2 regulates daily rhythms of insulin secretion capacity in MIN6 cells and isolated islets from male mice.

Seshadri N, Jonasson ME, Hunt KL, Xiang B, Cooper S, Wheeler MB, Dolinsky VW, Doucette CA.

Mol Metab. 2017 Apr 27;6(7):760-769. doi: 10.1016/j.molmet.2017.04.008. eCollection 2017 Jul.

12.

The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice.

Sassmann A, Gier B, Gröne HJ, Drews G, Offermanns S, Wettschureck N.

J Clin Invest. 2010 Jun;120(6):2184-93. doi: 10.1172/JCI41541. Epub 2010 May 3.

13.

Potentiation of insulin secretion and improvement of glucose intolerance by combining a novel G protein-coupled receptor 40 agonist DS-1558 with glucagon-like peptide-1 receptor agonists.

Nakashima R, Yano T, Ogawa J, Tanaka N, Toda N, Yoshida M, Takano R, Inoue M, Honda T, Kume S, Matsumoto K.

Eur J Pharmacol. 2014 Aug 15;737:194-201. doi: 10.1016/j.ejphar.2014.05.014. Epub 2014 May 22.

PMID:
24858371
14.

Differential role of GPR142 in tryptophan-mediated enhancement of insulin secretion in obese and lean mice.

Ueda Y, Iwakura H, Bando M, Doi A, Ariyasu H, Inaba H, Morita S, Akamizu T.

PLoS One. 2018 Jun 11;13(6):e0198762. doi: 10.1371/journal.pone.0198762. eCollection 2018.

15.

Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice.

Tan CP, Feng Y, Zhou YP, Eiermann GJ, Petrov A, Zhou C, Lin S, Salituro G, Meinke P, Mosley R, Akiyama TE, Einstein M, Kumar S, Berger JP, Mills SG, Thornberry NA, Yang L, Howard AD.

Diabetes. 2008 Aug;57(8):2211-9. doi: 10.2337/db08-0130. Epub 2008 May 13.

16.

Bombesin receptor subtype-3 (BRS-3) regulates glucose-stimulated insulin secretion in pancreatic islets across multiple species.

Feng Y, Guan XM, Li J, Metzger JM, Zhu Y, Juhl K, Zhang BB, Thornberry NA, Reitman ML, Zhou YP.

Endocrinology. 2011 Nov;152(11):4106-15. doi: 10.1210/en.2011-1440. Epub 2011 Aug 30.

PMID:
21878513
17.

Disruption of G protein-coupled receptor 39 impairs insulin secretion in vivo.

Tremblay F, Richard AM, Will S, Syed J, Stedman N, Perreault M, Gimeno RE.

Endocrinology. 2009 Jun;150(6):2586-95. doi: 10.1210/en.2008-1251. Epub 2009 Feb 12.

PMID:
19213841
18.

Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.

Alquier T, Peyot ML, Latour MG, Kebede M, Sorensen CM, Gesta S, Ronald Kahn C, Smith RD, Jetton TL, Metz TO, Prentki M, Poitout V.

Diabetes. 2009 Nov;58(11):2607-15. doi: 10.2337/db09-0362. Epub 2009 Aug 31.

19.

FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing.

Ang Z, Xiong D, Wu M, Ding JL.

FASEB J. 2018 Jan;32(1):289-303. doi: 10.1096/fj.201700252RR. Epub 2017 Sep 7.

20.

The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro.

Pingitore A, Chambers ES, Hill T, Maldonado IR, Liu B, Bewick G, Morrison DJ, Preston T, Wallis GA, Tedford C, Castañera González R, Huang GC, Choudhary P, Frost G, Persaud SJ.

Diabetes Obes Metab. 2017 Feb;19(2):257-265. doi: 10.1111/dom.12811. Epub 2016 Nov 23.

PMID:
27761989

Supplemental Content

Support Center