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Diallyl trisulfide protects against high glucose-induced cardiac apoptosis by stimulating the production of cystathionine gamma-lyase-derived hydrogen sulfide.

Tsai CY, Wen SY, Shibu MA, Yang YC, Peng H, Wang B, Wei YM, Chang HY, Lee CY, Huang CY, Kuo WW. Tsai CY, et al. Int J Cardiol. 2015 Sep 15;195:300-10. doi: 10.1016/j.ijcard.2015.05.111. Epub 2015 May 20. Int J Cardiol. 2015. PMID: 26056963

Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes.

Tsai CY, Wang CC, Lai TY, Tsu HN, Wang CH, Liang HY, Kuo WW. Tsai CY, et al. Int J Cardiol. 2013 Sep 30;168(2):1286-97. doi: 10.1016/j.ijcard.2012.12.004. Epub 2013 Feb 27. Int J Cardiol. 2013. PMID: 23453443

Diallyl trisufide (DATS) suppresses high glucose-induced cardiomyocyte apoptosis by inhibiting JNK/NFκB signaling via attenuating ROS generation.

Kuo WW, Wang WJ, Tsai CY, Way CL, Hsu HH, Chen LM. Kuo WW, et al. Int J Cardiol. 2013 Sep 20;168(1):270-80. doi: 10.1016/j.ijcard.2012.09.080. Epub 2012 Nov 13. Int J Cardiol. 2013. PMID: 23158927

The cystathionine γ-lyase/hydrogen sulfide pathway mediates the trimetazidine-induced protection of H9c2 cells against hypoxia/reoxygenation-induced apoptosis and oxidative stress.

Zheng W, Liu C. Zheng W, et al. Anatol J Cardiol. 2019 Sep;22(3):102-111. doi: 10.14744/AnatolJCardiol.2019.83648. Anatol J Cardiol. 2019. PMID: 31475956 Free PMC article.

Role of the cystathionine γ lyase/hydrogen sulfide pathway in human melanoma progression.

Panza E, De Cicco P, Armogida C, Scognamiglio G, Gigantino V, Botti G, Germano D, Napolitano M, Papapetropoulos A, Bucci M, Cirino G, Ianaro A. Panza E, et al. Pigment Cell Melanoma Res. 2015 Jan;28(1):61-72. doi: 10.1111/pcmr.12312. Epub 2014 Oct 6. Pigment Cell Melanoma Res. 2015. PMID: 25205294

Diallyl trisulfide protects against ethanol-induced oxidative stress and apoptosis via a hydrogen sulfide-mediated mechanism.

Chen LY, Chen Q, Zhu XJ, Kong DS, Wu L, Shao JJ, Zheng SZ. Chen LY, et al. Int Immunopharmacol. 2016 Jul;36:23-30. doi: 10.1016/j.intimp.2016.04.015. Epub 2016 Apr 22. Int Immunopharmacol. 2016. PMID: 27107369

The protective effects of endogenous hydrogen sulfide modulator, S-propargyl-cysteine, on high glucose-induced apoptosis in cardiomyocytes: A novel mechanism mediated by the activation of Nrf2.

Yang H, Mao Y, Tan B, Luo S, Zhu Y. Yang H, et al. Eur J Pharmacol. 2015 Aug 15;761:135-43. doi: 10.1016/j.ejphar.2015.05.001. Epub 2015 May 12. Eur J Pharmacol. 2015. PMID: 25979858

Dysregulation of cystathionine γ-lyase (CSE)/hydrogen sulfide pathway contributes to ox-LDL-induced inflammation in macrophage.

Wang XH, Wang F, You SJ, Cao YJ, Cao LD, Han Q, Liu CF, Hu LF. Wang XH, et al. Cell Signal. 2013 Nov;25(11):2255-62. doi: 10.1016/j.cellsig.2013.07.010. Epub 2013 Jul 18. Cell Signal. 2013. PMID: 23872072

Diallyl Trisulfide Suppresses Oxidative Stress-Induced Activation of Hepatic Stellate Cells through Production of Hydrogen Sulfide.

Zhang F, Jin H, Wu L, Shao J, Zhu X, Chen A, Zheng S. Zhang F, et al. Oxid Med Cell Longev. 2017;2017:1406726. doi: 10.1155/2017/1406726. Epub 2017 Feb 20. Oxid Med Cell Longev. 2017. PMID: 28303169 Free PMC article.

Diallyl Trisulfide (DATS) Suppresses AGE-Induced Cardiomyocyte Apoptosis by Targeting ROS-Mediated PKCδ Activation.

Hsieh DJ, Ng SC, Zeng RY, Padma VV, Huang CY, Kuo WW. Hsieh DJ, et al. Int J Mol Sci. 2020 Apr 9;21(7):2608. doi: 10.3390/ijms21072608. Int J Mol Sci. 2020. PMID: 32283691 Free PMC article.

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