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CagA of Helicobacter pylori interacts with and inhibits the serine-threonine kinase PRK2.

Mishra JP, Cohen D, Zamperone A, Nesic D, Muesch A, Stein M.

Cell Microbiol. 2015 Nov;17(11):1670-82. doi: 10.1111/cmi.12464. Epub 2015 Jun 19.


Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity.

Saadat I, Higashi H, Obuse C, Umeda M, Murata-Kamiya N, Saito Y, Lu H, Ohnishi N, Azuma T, Suzuki A, Ohno S, Hatakeyama M.

Nature. 2007 May 17;447(7142):330-3.


Helicobacter pylori stimulates epithelial cell migration via CagA-mediated perturbation of host cell signaling.

Kikuchi K, Murata-Kamiya N, Kondo S, Hatakeyama M.

Microbes Infect. 2012 May;14(5):470-6. doi: 10.1016/j.micinf.2011.12.003. Epub 2011 Dec 11.


Natural variant of the Helicobacter pylori CagA oncoprotein that lost the ability to interact with PAR1.

Hashi K, Murata-Kamiya N, Varon C, Mégraud F, Dominguez-Bello MG, Hatakeyama M.

Cancer Sci. 2014 Mar;105(3):245-51. doi: 10.1111/cas.12342. Epub 2014 Feb 12.


Impact of structural polymorphism for the Helicobacter pylori CagA oncoprotein on binding to polarity-regulating kinase PAR1b.

Nishikawa H, Hayashi T, Arisaka F, Senda T, Hatakeyama M.

Sci Rep. 2016 Jul 22;6:30031. doi: 10.1038/srep30031.


Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA.

Tegtmeyer N, Neddermann M, Asche CI, Backert S.

Mol Microbiol. 2017 Aug;105(3):358-372. doi: 10.1111/mmi.13707. Epub 2017 May 30. Review.


Role of partitioning-defective 1/microtubule affinity-regulating kinases in the morphogenetic activity of Helicobacter pylori CagA.

Lu H, Murata-Kamiya N, Saito Y, Hatakeyama M.

J Biol Chem. 2009 Aug 21;284(34):23024-36. doi: 10.1074/jbc.M109.001008. Epub 2009 Jun 24.


Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates.

Nesić D, Miller MC, Quinkert ZT, Stein M, Chait BT, Stebbins CE.

Nat Struct Mol Biol. 2010 Jan;17(1):130-2. doi: 10.1038/nsmb.1705. Epub 2009 Dec 6.


Interaction between the Helicobacter pylori CagA and alpha-Pix in gastric epithelial AGS cells.

Baek HY, Lim JW, Kim H.

Ann N Y Acad Sci. 2007 Jan;1096:18-23.


Helicobacter pylori and gastric carcinogenesis.

Hatakeyama M.

J Gastroenterol. 2009;44(4):239-48. doi: 10.1007/s00535-009-0014-1. Epub 2009 Mar 7. Review.


Structural and functional diversity in the PAR1b/MARK2-binding region of Helicobacter pylori CagA.

Lu HS, Saito Y, Umeda M, Murata-Kamiya N, Zhang HM, Higashi H, Hatakeyama M.

Cancer Sci. 2008 Oct;99(10):2004-11. doi: 10.1111/j.1349-7006.2008.00950.x.


Helicobacter pylori CagA protein induces factors involved in the epithelial to mesenchymal transition (EMT) in infected gastric epithelial cells in an EPIYA- phosphorylation-dependent manner.

Sougleri IS, Papadakos KS, Zadik MP, Mavri-Vavagianni M, Mentis AF, Sgouras DN.

FEBS J. 2016 Jan;283(2):206-20. doi: 10.1111/febs.13592. Epub 2015 Dec 11.


Attenuation of Helicobacter pylori CagA x SHP-2 signaling by interaction between CagA and C-terminal Src kinase.

Tsutsumi R, Higashi H, Higuchi M, Okada M, Hatakeyama M.

J Biol Chem. 2003 Feb 7;278(6):3664-70. Epub 2002 Nov 21.


Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis.

Tegtmeyer N, Wessler S, Backert S.

FEBS J. 2011 Apr;278(8):1190-202. doi: 10.1111/j.1742-4658.2011.08035.x. Epub 2011 Feb 25. Review.


Sequence Polymorphism and Intrinsic Structural Disorder as Related to Pathobiological Performance of the Helicobacter pylori CagA Oncoprotein.

Nishikawa H, Hatakeyama M.

Toxins (Basel). 2017 Apr 13;9(4). pii: E136. doi: 10.3390/toxins9040136. Review.


[Oncogenic mechanism of Helicobacter pylori].

Hatakeyama M.

Nihon Rinsho Meneki Gakkai Kaishi. 2008 Jun;31(3):132-40. Japanese.


Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA.

Tsutsumi R, Takahashi A, Azuma T, Higashi H, Hatakeyama M.

Mol Cell Biol. 2006 Jan;26(1):261-76.


Haem oxygenase-1 inhibits phosphorylation of the Helicobacter pylori oncoprotein CagA in gastric epithelial cells.

Gobert AP, Verriere T, de Sablet T, Peek RM Jr, Chaturvedi R, Wilson KT.

Cell Microbiol. 2013 Jan;15(1):145-56. doi: 10.1111/cmi.12039. Epub 2012 Nov 7.


The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation.

Selbach M, Moese S, Hurwitz R, Hauck CR, Meyer TF, Backert S.

EMBO J. 2003 Feb 3;22(3):515-28.

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