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26025474,24269813,24747563,34304130,26099526,25460735,29159825,25524063,32404932,28190475,27534992,28442273,19501927,30664797,25156247,27573244,22376231,32607891,35869657,30120929,21645218,26305715,30803859,17283114,18036573,18972444,26579442,30836218,36209823,33290278,29375205,28892150,19572984,29730159,18198478,23700488,27859576,27062444,23663886,27167736,28496104,15885730,29721568,18948497,24548803,27605663,28895119,29660435,27122661,31450152,28711154,24217957,26655953,17383432,31986416,25655198,27939985,36909161,33784797,18316028,19195631,29870742,27739086,30037014,25690590,23461012,27773935,36706173,32141703,24954587,28428116,28714273,24713361,26682726,16357057,20868235,23811326,26740296,18599584,23299969,26812075,35689610,30392748,31188634,25583360,35930537,28673684,27932556,33068587,17127137,24262277,31325638,30411084,33665587,36709356,21540105,23646923,29107287,28130067,27666676,35251469,24280415,32325178,31195351,35338490,23787969,31409057,30635917,29802399,25309079,36107013,35985473,29800811,19965603,22273278,21535024,32552182,20842630,30933435,19182371,31201553,32306456,34870866,34523155,34268860,26867493,30038487,32604760,32087348,31117231,29123032,28894223,35163821,35491473,20682011,34423788,35576742,33959012,30192394,33015098,31129048,34603061,33581174,32991173,32329946,24091600,24498295,24773203,30602573,32355674,27889186,23872024,27709009,30520052,22474109,36448414,34116071,27639801,11254735,23802886,16864508,34267188,21123943,25536043,21211565,20699418,17321001,23200777,34690775,22261820,35277054,28550049,35054960,29028769,32534989,35429548,27124661,35068872,31940200,34921864,30702902,30206765,36130662,37058105,28546081,22676331,30403751,24456332,35456053,32553670,22728874,21593203,15597091,36555867,31731192,29597356,29148806,35597796,30294325,30951700,23460643,35623174,30256818,32418220,19398233,35040254,31004178,29763374,36904254,36154116,19387919,33713857,36336231,23507574,36655918,34270928,20573685,35786161,25217800,31671697,34759011,35955885,32984886,25356030,22884994,35472625,31438968,4018729,21707532,28983452,29235014,36162519,36430732,34027340,34525389,24430730,31883408,30454825,36835145,32190913,32377219,34995284,87483,31540133,23731694,22206017,34834064,24833709,30115921,29323242,23763294,33073044,25184625,33598648,27239399,33545430,31034614,30580029,34896286,35240510,32557026,32197424,32038785,24483773,23449255,34774847,36803569,36708882,28162230,29096734,30517762,32398264,30658730,34064981,36377258,19221436,11825853,34998040,33930378,32796650,32875282,31949131,32919135,31173814,35640740,19155080,31679693,31197565,33067186,35400467,32029510,33325949,32671585,32701948,31840358,19957376,36191854,35761571,32248671,21790669,27403993,33106141,31696159,6295907,29669937,32686578,27213081,22997409,34889100,32583938,36347091,20659474,32314869,36375336,28586124,33857491,20868231,35867996,31114130,2059245,32268085,26904554,29098111,30025151,36826472,34396890,26992446,36739928,35797110,26594598,36174925,21947253,33162823,29404516,15970563,36196594,33321885,36807831,28988570,31971384,33631374,35700583,32514497,33624852,11472435,23813550,35554627,20460374,22187656,32355675,35156518,21354120,31076642,35217809,6336713,34035824,32200644,35397391,33849361,28870670,2258155,33895191,33860214,25352951,31701069,30090613,30658725,33994911,36690432,32047433,23849208,31199920,21672564,29928671,31909359,36737665,26835538,33905196,31188604,36875742,30658726,28411363,36809683,21319202,36626632,19645734,29670525,28492308,30660600,37005411,27733832,20463294,29892294,36145643,25926979,26201322,32050066,31214376,34973190,26867181,31474877,33294085,6751130,35619282,21286378,27777888,32626893,34811964,20395005,9719392,36353888,9751944,31123622,35982712,36703463,35704802,1744427,34887405,24570954,31061954,34327512,34596220,22861370,36923641,33826947,27709014,27342423,29900399,22489260,31632541,32012846,30680167,30283336,34335299,31982006,36008929,26005679,33435328,31555134,31491888,32064266,33770118,8015491,3234242,36768731,6822376,3695814,30826275,29038503,32939922,30362097,32582865,32500081,36454392,3226358,29404515,28596796,35790996,35605722,28164071,36873184,34888230,29457048,32635847,34531950,33290990,21757150,27138729,35933684,2795524,26909225,16499204,34804432,34141166,15706758,36590256,34290612,36418288,29795774,26201327,37111128,23813144,31933989,8445213,35747395,32477115,1845298,30191025,30279623,25040591,30386459,35754511,32371195,22007317,29924722,34659635,32674619,26357621,32118004,7948006,28926117,16499202,16499203,16499205,32275777,31798089,34414117,11151050,19669341,33819305,36334655,37056984,36630370,24580680,35892055,17617114,34627652,35022579,34430534,34493776,31894088,37148318,34159177,35112549,30992829[uid]

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Excessive bile acid activated NF-kappa B and promoted the development of alcoholic steatohepatitis in farnesoid X receptor deficient mice.

Wu WB, Chen YY, Zhu B, Peng XM, Zhang SW, Zhou ML. Wu WB, et al. Biochimie. 2015 Aug;115:86-92. doi: 10.1016/j.biochi.2015.05.014. Epub 2015 May 27. Biochimie. 2015. PMID: 26025474

Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease.

Wu W, Zhu B, Peng X, Zhou M, Jia D, Gu J. Wu W, et al. Biochem Biophys Res Commun. 2014 Jan 3;443(1):68-73. doi: 10.1016/j.bbrc.2013.11.057. Epub 2013 Nov 20. Biochem Biophys Res Commun. 2014. PMID: 24269813

Bile acids override steatosis in farnesoid X receptor deficient mice in a model of non-alcoholic steatohepatitis.

Wu W, Liu X, Peng X, Xue R, Ji L, Shen X, Chen S, Gu J, Zhang S. Wu W, et al. Biochem Biophys Res Commun. 2014 May 23;448(1):50-5. doi: 10.1016/j.bbrc.2014.04.048. Epub 2014 Apr 18. Biochem Biophys Res Commun. 2014. PMID: 24747563

Yangonin modulates lipid homeostasis, ameliorates cholestasis and cellular senescence in alcoholic liver disease via activating nuclear receptor FXR.

Kong L, Dong R, Huang K, Wang X, Wang D, Yue N, Wang C, Sun P, Gu J, Luo H, Liu K, Wu J, Sun H, Meng Q. Kong L, et al. Phytomedicine. 2021 Sep;90:153629. doi: 10.1016/j.phymed.2021.153629. Epub 2021 Jun 17. Phytomedicine. 2021. PMID: 34304130

Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans.

Xu MJ, Cai Y, Wang H, Altamirano J, Chang B, Bertola A, Odena G, Lu J, Tanaka N, Matsusue K, Matsubara T, Mukhopadhyay P, Kimura S, Pacher P, Gonzalez FJ, Bataller R, Gao B. Xu MJ, et al. Gastroenterology. 2015 Oct;149(4):1030-41.e6. doi: 10.1053/j.gastro.2015.06.009. Epub 2015 Jun 20. Gastroenterology. 2015. PMID: 26099526 Free PMC article.

Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity.

Manley S, Ni HM, Williams JA, Kong B, DiTacchio L, Guo G, Ding WX. Manley S, et al. Redox Biol. 2014;2:991-1002. doi: 10.1016/j.redox.2014.08.007. Epub 2014 Aug 28. Redox Biol. 2014. PMID: 25460735 Free PMC article.

Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice.

Hartmann P, Hochrath K, Horvath A, Chen P, Seebauer CT, Llorente C, Wang L, Alnouti Y, Fouts DE, Stärkel P, Loomba R, Coulter S, Liddle C, Yu RT, Ling L, Rossi SJ, DePaoli AM, Downes M, Evans RM, Brenner DA, Schnabl B. Hartmann P, et al. Hepatology. 2018 Jun;67(6):2150-2166. doi: 10.1002/hep.29676. Epub 2018 Apr 16. Hepatology. 2018. PMID: 29159825 Free PMC article.

Role of Fn14 in acute alcoholic steatohepatitis in mice.

Karaca G, Xie G, Moylan C, Swiderska-Syn M, Guy CD, Krüger L, Machado MV, Choi SS, Michelotti GA, Burkly LC, Diehl AM. Karaca G, et al. Am J Physiol Gastrointest Liver Physiol. 2015 Feb 15;308(4):G325-34. doi: 10.1152/ajpgi.00429.2013. Epub 2014 Dec 18. Am J Physiol Gastrointest Liver Physiol. 2015. PMID: 25524063 Free PMC article.

Enhanced alcoholic liver disease in mice with intestine-specific farnesoid X receptor deficiency.

Huang M, Kong B, Zhang M, Rizzolo D, Armstrong LE, Schumacher JD, Chow MD, Lee YH, Joseph LB, Stofan M, Zhang L, Guo GL. Huang M, et al. Lab Invest. 2020 Sep;100(9):1158-1168. doi: 10.1038/s41374-020-0439-y. Epub 2020 May 13. Lab Invest. 2020. PMID: 32404932 Free PMC article.

Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor.

Duan X, Meng Q, Wang C, Liu Z, Liu Q, Sun H, Sun P, Yang X, Huo X, Peng J, Liu K. Duan X, et al. Phytomedicine. 2017 Feb 15;25:83-92. doi: 10.1016/j.phymed.2016.12.006. Epub 2016 Dec 13. Phytomedicine. 2017. PMID: 28190475

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