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Items: 1 to 20 of 130

1.

New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccine Na-APR-1M74.

Pearson MS, Jariwala AR, Abbenante G, Plieskatt J, Wilson D, Bottazzi ME, Hotez PJ, Keegan B, Bethony JM, Loukas A.

Hum Vaccin Immunother. 2015;11(5):1251-7. doi: 10.4161/21645515.2014.980199.

2.

Expression, purification, and characterization of the Necator americanus aspartic protease-1 (Na-APR-1 (M74)) antigen, a component of the bivalent human hookworm vaccine.

Seid CA, Curti E, Jones RM, Hudspeth E, Rezende W, Pollet J, Center L, Versteeg L, Pritchard S, Musiychuk K, Yusibov V, Hotez PJ, Bottazzi ME.

Hum Vaccin Immunother. 2015;11(6):1474-88. doi: 10.1080/21645515.2015.1036207.

3.

Neutralizing antibodies to the hookworm hemoglobinase Na-APR-1: implications for a multivalent vaccine against hookworm infection and schistosomiasis.

Pearson MS, Pickering DA, Tribolet L, Cooper L, Mulvenna J, Oliveira LM, Bethony JM, Hotez PJ, Loukas A.

J Infect Dis. 2010 May 15;201(10):1561-9. doi: 10.1086/651953.

PMID:
20367477
4.

An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection.

Pearson MS, Bethony JM, Pickering DA, de Oliveira LM, Jariwala A, Santiago H, Miles AP, Zhan B, Jiang D, Ranjit N, Mulvenna J, Tribolet L, Plieskatt J, Smith T, Bottazzi ME, Jones K, Keegan B, Hotez PJ, Loukas A.

FASEB J. 2009 Sep;23(9):3007-19. doi: 10.1096/fj.09-131433. Epub 2009 Apr 20.

5.

Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults.

Diemert DJ, Freire J, Valente V, Fraga CG, Talles F, Grahek S, Campbell D, Jariwala A, Periago MV, Enk M, Gazzinelli MF, Bottazzi ME, Hamilton R, Brelsford J, Yakovleva A, Li G, Peng J, Correa-Oliveira R, Hotez P, Bethony J.

PLoS Negl Trop Dis. 2017 May 2;11(5):e0005574. doi: 10.1371/journal.pntd.0005574. eCollection 2017 May.

6.

The evaluation of recombinant hookworm antigens as vaccines in hamsters (Mesocricetus auratus) challenged with human hookworm, Necator americanus.

Xiao S, Zhan B, Xue J, Goud GN, Loukas A, Liu Y, Williamson A, Liu S, Deumic V, Hotez P.

Exp Parasitol. 2008 Jan;118(1):32-40. Epub 2007 Jun 6.

PMID:
17645877
7.

Peptide-based subunit vaccine against hookworm infection.

Skwarczynski M, Dougall AM, Khoshnejad M, Chandrudu S, Pearson MS, Loukas A, Toth I.

PLoS One. 2012;7(10):e46870. doi: 10.1371/journal.pone.0046870. Epub 2012 Oct 3.

8.

Molecular cloning, biochemical characterization, and partial protective immunity of the heme-binding glutathione S-transferases from the human hookworm Necator americanus.

Zhan B, Perally S, Brophy PM, Xue J, Goud G, Liu S, Deumic V, de Oliveira LM, Bethony J, Bottazzi ME, Jiang D, Gillespie P, Xiao SH, Gupta R, Loukas A, Ranjit N, Lustigman S, Oksov Y, Hotez P.

Infect Immun. 2010 Apr;78(4):1552-63. doi: 10.1128/IAI.00848-09. Epub 2010 Feb 9.

9.

Enhanced protective efficacy of a chimeric form of the schistosomiasis vaccine antigen Sm-TSP-2.

Pearson MS, Pickering DA, McSorley HJ, Bethony JM, Tribolet L, Dougall AM, Hotez PJ, Loukas A.

PLoS Negl Trop Dis. 2012;6(3):e1564. doi: 10.1371/journal.pntd.0001564. Epub 2012 Mar 13.

10.

Advances in neglected tropical disease vaccines: Developing relative potency and functional assays for the Na-GST-1/Alhydrogel hookworm vaccine.

Brelsford JB, Plieskatt JL, Yakovleva A, Jariwala A, Keegan BP, Peng J, Xia P, Li G, Campbell D, Periago MV, Correa-Oliveira R, Bottazzi ME, Hotez PJ, Diemert D, Bethony JM.

PLoS Negl Trop Dis. 2017 Feb 13;11(2):e0005385. doi: 10.1371/journal.pntd.0005385. eCollection 2017 Feb.

11.

Experimental approaches to the development of a recombinant hookworm vaccine.

Hotez PJ, Ghosh K, Hawdon JM, Narasimhan S, Jones B, Shuhua X, Sen L, Bin Z, Haechou X, Hainan R, Heng W, Koski RA.

Immunol Rev. 1999 Oct;171:163-71. Review.

PMID:
10582170
12.

Hookworm burden reductions in BALB/c mice vaccinated with recombinant Ancylostoma secreted proteins (ASPs) from Ancylostoma duodenale, Ancylostoma caninum and Necator americanus.

Sen L, Ghosh K, Bin Z, Qiang S, Thompson MG, Hawdon JM, Koski RA, Shuhua X, Hotez PJ.

Vaccine. 2000 Jan 6;18(11-12):1096-102.

PMID:
10590331
13.
14.

Optimization and revision of the production process of the Necator americanus glutathione S-transferase 1 (Na-GST-1), the lead hookworm vaccine recombinant protein candidate.

Curti E, Seid CA, Hudspeth E, Center L, Rezende W, Pollet J, Kwityn C, Hammond M, Matsunami RK, Engler DA, Hotez PJ, Elena Bottazzi M.

Hum Vaccin Immunother. 2014;10(7):1914-25. doi: 10.4161/hv.28872.

15.

Randomized, placebo-controlled, double-blind trial of the Na-ASP-2 hookworm vaccine in unexposed adults.

Bethony JM, Simon G, Diemert DJ, Parenti D, Desrosiers A, Schuck S, Fujiwara R, Santiago H, Hotez PJ.

Vaccine. 2008 May 2;26(19):2408-17. doi: 10.1016/j.vaccine.2008.02.049. Epub 2008 Mar 11.

PMID:
18396361
16.

Effect of combining the larval antigens Ancylostoma secreted protein 2 (ASP-2) and metalloprotease 1 (MTP-1) in protecting hamsters against hookworm infection and disease caused by Ancylostoma ceylanicum.

Mendez S, Zhan B, Goud G, Ghosh K, Dobardzic A, Wu W, Liu S, Deumic V, Dobardzic R, Liu Y, Bethony J, Hotez PJ.

Vaccine. 2005 May 2;23(24):3123-30.

PMID:
15837211
17.

Hamsters vaccinated with Ace-mep-7 DNA vaccine produced protective immunity against Ancylostoma ceylanicum infection.

Wiśniewski M, Jaros S, Bąska P, Cappello M, Długosz E, Wędrychowicz H.

Exp Parasitol. 2016 Apr;163:1-7. doi: 10.1016/j.exppara.2016.01.006. Epub 2016 Jan 18.

PMID:
26795262
18.

Lipopeptide Nanoparticles: Development of Vaccines against Hookworm Parasite.

Fuaad AA, Pearson MS, Pickering DA, Becker L, Zhao G, Loukas AC, Skwarczynski M, Toth I.

ChemMedChem. 2015 Oct;10(10):1647-54. doi: 10.1002/cmdc.201500227. Epub 2015 Aug 12.

PMID:
26269385
20.

A history of hookworm vaccine development.

Schneider B, Jariwala AR, Periago MV, Gazzinelli MF, Bose SN, Hotez PJ, Diemert DJ, Bethony JM.

Hum Vaccin. 2011 Nov;7(11):1234-44. doi: 10.4161/hv.7.11.18443. Epub 2011 Nov 1. Review.

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