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Items: 1 to 20 of 119

1.

Porphyromonas gingivalis-derived RgpA-Kgp Complex Activates the Macrophage Urokinase Plasminogen Activator System: IMPLICATIONS FOR PERIODONTITIS.

Fleetwood AJ, O'Brien-Simpson NM, Veith PD, Lam RS, Achuthan A, Cook AD, Singleton W, Lund IK, Reynolds EC, Hamilton JA.

J Biol Chem. 2015 Jun 26;290(26):16031-42. doi: 10.1074/jbc.M115.645572. Epub 2015 May 15.

2.

Role of RgpA, RgpB, and Kgp proteinases in virulence of Porphyromonas gingivalis W50 in a murine lesion model.

O'Brien-Simpson NM, Paolini RA, Hoffmann B, Slakeski N, Dashper SG, Reynolds EC.

Infect Immun. 2001 Dec;69(12):7527-34.

3.

Porphyromonas gingivalis gingipains: the molecular teeth of a microbial vampire.

O-Brien-Simpson NM, Veith PD, Dashper SG, Reynolds EC.

Curr Protein Pept Sci. 2003 Dec;4(6):409-26. Review.

PMID:
14683427
4.

An immune response directed to proteinase and adhesin functional epitopes protects against Porphyromonas gingivalis-induced periodontal bone loss.

O'Brien-Simpson NM, Pathirana RD, Paolini RA, Chen YY, Veith PD, Tam V, Ally N, Pike RN, Reynolds EC.

J Immunol. 2005 Sep 15;175(6):3980-9.

5.

Kgp and RgpB, but not RgpA, are important for Porphyromonas gingivalis virulence in the murine periodontitis model.

Pathirana RD, O'Brien-Simpson NM, Brammar GC, Slakeski N, Reynolds EC.

Infect Immun. 2007 Mar;75(3):1436-42. Epub 2007 Jan 12.

6.

The role of RgpA in the pathogenicity of Porphyromonas gingivalis in the murine periodontitis model.

Wilensky A, Polak D, Houri-Haddad Y, Shapira L.

J Clin Periodontol. 2013 Oct;40(10):924-32. doi: 10.1111/jcpe.12139. Epub 2013 Aug 4.

PMID:
23909600
7.

Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome.

Pomowski A, Usón I, Nowakowska Z, Veillard F, Sztukowska MN, Guevara T, Goulas T, Mizgalska D, Nowak M, Potempa B, Huntington JA, Potempa J, Gomis-Rüth FX.

J Biol Chem. 2017 Apr 7;292(14):5724-5735. doi: 10.1074/jbc.M117.776724. Epub 2017 Feb 14.

8.
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10.

Hemoglobin hydrolysis and heme acquisition by Porphyromonas gingivalis.

Dashper SG, Cross KJ, Slakeski N, Lissel P, Aulakh P, Moore C, Reynolds EC.

Oral Microbiol Immunol. 2004 Feb;19(1):50-6.

PMID:
14678474
11.

The role of gingipains in the pathogenesis of periodontal disease.

Imamura T.

J Periodontol. 2003 Jan;74(1):111-8. Review.

PMID:
12593605
12.

Attenuation of the phosphatidylinositol 3-kinase/Akt signaling pathway by Porphyromonas gingivalis gingipains RgpA, RgpB, and Kgp.

Nakayama M, Inoue T, Naito M, Nakayama K, Ohara N.

J Biol Chem. 2015 Feb 20;290(8):5190-202. doi: 10.1074/jbc.M114.591610. Epub 2015 Jan 6.

13.

GM-CSF and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.

Lam RS, O'Brien-Simpson NM, Hamilton JA, Lenzo JC, Holden JA, Brammar GC, Orth RK, Tan Y, Walsh KA, Fleetwood AJ, Reynolds EC.

Immunol Cell Biol. 2015 Sep;93(8):705-15. doi: 10.1038/icb.2015.25. Epub 2015 Mar 10.

PMID:
25753270
14.

Suppression of inflammatory responses of human gingival fibroblasts by gingipains from Porphyromonas gingivalis.

Palm E, Khalaf H, Bengtsson T.

Mol Oral Microbiol. 2015 Feb;30(1):74-85. doi: 10.1111/omi.12073. Epub 2014 Sep 19.

PMID:
25055828
15.

Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis.

de Diego I, Veillard F, Sztukowska MN, Guevara T, Potempa B, Pomowski A, Huntington JA, Potempa J, Gomis-Rüth FX.

J Biol Chem. 2014 Nov 14;289(46):32291-302. doi: 10.1074/jbc.M114.602052. Epub 2014 Sep 29.

16.

Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-α and interleukin-1β but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain.

Akiyama T, Miyamoto Y, Yoshimura K, Yamada A, Takami M, Suzawa T, Hoshino M, Imamura T, Akiyama C, Yasuhara R, Mishima K, Maruyama T, Kohda C, Tanaka K, Potempa J, Yasuda H, Baba K, Kamijo R.

J Biol Chem. 2014 May 30;289(22):15621-30. doi: 10.1074/jbc.M113.520510. Epub 2014 Apr 22.

17.

The RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis Inactivate the Th2 cytokines interleukin-4 and interleukin-5.

Tam V, O'Brien-Simpson NM, Chen YY, Sanderson CJ, Kinnear B, Reynolds EC.

Infect Immun. 2009 Apr;77(4):1451-8. doi: 10.1128/IAI.01377-08. Epub 2009 Jan 21.

18.

Generation of lys-gingipain protease activity in Porphyromonas gingivalis W50 is independent of Arg-gingipain protease activities.

Aduse-Opoku J, Davies NN, Gallagher A, Hashim A, Evans HE, Rangarajan M, Slaney JM, Curtis MA.

Microbiology. 2000 Aug;146 ( Pt 8):1933-40.

PMID:
10931897
19.

Serum immunoglobulin G (IgG) and IgG subclass responses to the RgpA-Kgp proteinase-adhesin complex of Porphyromonas gingivalis in adult periodontitis.

O'Brien-Simpson NM, Black CL, Bhogal PS, Cleal SM, Slakeski N, Higgins TJ, Reynolds EC.

Infect Immun. 2000 May;68(5):2704-12.

20.

Identification of gingipain-specific I-A(b) -restricted CD4+ T cells following mucosal colonization with Porphyromonas gingivalis in C57BL/6 mice.

Bittner-Eddy PD, Fischer LA, Costalonga M.

Mol Oral Microbiol. 2013 Dec;28(6):452-66. doi: 10.1111/omi.12038. Epub 2013 Aug 14.

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