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Items: 1 to 20 of 93

1.

Ghrelin Inhibition Restores Glucose Homeostasis in Hepatocyte Nuclear Factor-1α (MODY3)-Deficient Mice.

Brial F, Lussier CR, Belleville K, Sarret P, Boudreau F.

Diabetes. 2015 Sep;64(9):3314-20. doi: 10.2337/db15-0124. Epub 2015 May 15.

2.

HNF1α defect influences post-prandial lipid regulation.

St-Jean M, Boudreau F, Carpentier AC, Hivert MF.

PLoS One. 2017 May 11;12(5):e0177110. doi: 10.1371/journal.pone.0177110. eCollection 2017.

3.

Long-term treatment with the ghrelin receptor antagonist [d-Lys3]-GHRP-6 does not improve glucose homeostasis in nonobese diabetic MKR mice.

Mosa R, Huang L, Li H, Grist M, LeRoith D, Chen C.

Am J Physiol Regul Integr Comp Physiol. 2018 Jan 1;314(1):R71-R83. doi: 10.1152/ajpregu.00157.2017. Epub 2017 Sep 13.

4.

Roles of HNF1α and HNF4α in pancreatic β-cells: lessons from a monogenic form of diabetes (MODY).

Yamagata K.

Vitam Horm. 2014;95:407-23. doi: 10.1016/B978-0-12-800174-5.00016-8. Review.

PMID:
24559927
5.

Repression of HNF1α-mediated transcription by amino-terminal enhancer of split (AES).

Han EH, Gorman AA, Singh P, Chi YI.

Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):14-20. doi: 10.1016/j.bbrc.2015.11.007. Epub 2015 Nov 6.

PMID:
26549228
6.

Hypoglycemic Effect of Combined Ghrelin and Glucagon Receptor Blockade.

Mani BK, Uchida A, Lee Y, Osborne-Lawrence S, Charron MJ, Unger RH, Berglund ED, Zigman JM.

Diabetes. 2017 Jul;66(7):1847-1857. doi: 10.2337/db16-1303. Epub 2017 May 9.

7.

Metabolomics identifies novel Hnf1alpha-dependent physiological pathways in vivo.

Bonzo JA, Patterson AD, Krausz KW, Gonzalez FJ.

Mol Endocrinol. 2010 Dec;24(12):2343-55. doi: 10.1210/me.2010-0130. Epub 2010 Oct 13.

8.

Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells.

Donelan W, Koya V, Li SW, Yang LJ.

J Biol Chem. 2010 Apr 16;285(16):12181-9. doi: 10.1074/jbc.M109.064238. Epub 2010 Jan 27.

9.

Selective deletion of the Hnf1beta (MODY5) gene in beta-cells leads to altered gene expression and defective insulin release.

Wang L, Coffinier C, Thomas MK, Gresh L, Eddu G, Manor T, Levitsky LL, Yaniv M, Rhoads DB.

Endocrinology. 2004 Aug;145(8):3941-9. Epub 2004 May 13.

PMID:
15142986
10.

Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion.

Fujita Y, Wideman RD, Asadi A, Yang GK, Baker R, Webber T, Zhang T, Wang R, Ao Z, Warnock GL, Kwok YN, Kieffer TJ.

Gastroenterology. 2010 May;138(5):1966-75. doi: 10.1053/j.gastro.2010.01.049. Epub 2010 Feb 4.

PMID:
20138041
11.

Glucose-Dependent Insulinotropic Peptide Stimulates Glucagon-Like Peptide 1 Production by Pancreatic Islets via Interleukin 6, Produced by α Cells.

Timper K, Dalmas E, Dror E, Rütti S, Thienel C, Sauter NS, Bouzakri K, Bédat B, Pattou F, Kerr-Conte J, Böni-Schnetzler M, Donath MY.

Gastroenterology. 2016 Jul;151(1):165-79. doi: 10.1053/j.gastro.2016.03.003. Epub 2016 Mar 10.

PMID:
26971825
12.

Islet β-cell ghrelin signaling for inhibition of insulin secretion.

Dezaki K, Yada T.

Methods Enzymol. 2012;514:317-31. doi: 10.1016/B978-0-12-381272-8.00020-9. Review.

PMID:
22975062
13.

TCF1 links GIPR signaling to the control of beta cell function and survival.

Campbell JE, Ussher JR, Mulvihill EE, Kolic J, Baggio LL, Cao X, Liu Y, Lamont BJ, Morii T, Streutker CJ, Tamarina N, Philipson LH, Wrana JL, MacDonald PE, Drucker DJ.

Nat Med. 2016 Jan;22(1):84-90. doi: 10.1038/nm.3997. Epub 2015 Dec 7.

PMID:
26642437
14.

Ectopic expression of GIP in pancreatic β-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides.

Fukami A, Seino Y, Ozaki N, Yamamoto M, Sugiyama C, Sakamoto-Miura E, Himeno T, Takagishi Y, Tsunekawa S, Ali S, Drucker DJ, Murata Y, Seino Y, Oiso Y, Hayashi Y.

Diabetes. 2013 Feb;62(2):510-8. doi: 10.2337/db12-0294. Epub 2012 Oct 25.

15.

Hnf1α (MODY3) regulates β-cell-enriched MafA transcription factor expression.

Hunter CS, Maestro MA, Raum JC, Guo M, Thompson FH 3rd, Ferrer J, Stein R.

Mol Endocrinol. 2011 Feb;25(2):339-47. doi: 10.1210/me.2010-0362. Epub 2010 Dec 30.

16.

Tubular proteinuria in patients with HNF1α mutations: HNF1α drives endocytosis in the proximal tubule.

Terryn S, Tanaka K, Lengelé JP, Olinger E, Dubois-Laforgue D, Garbay S, Kozyraki R, Van Der Smissen P, Christensen EI, Courtoy PJ, Bellanné-Chantelot C, Timsit J, Pontoglio M, Devuyst O.

Kidney Int. 2016 May;89(5):1075-1089. doi: 10.1016/j.kint.2016.01.027. Epub 2016 Mar 29.

PMID:
27083284
17.

Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice.

Ma X, Lin Y, Lin L, Qin G, Pereira FA, Haymond MW, Butte NF, Sun Y.

Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E422-31. doi: 10.1152/ajpendo.00576.2011. Epub 2012 Jun 5.

18.

Ghrelin regulates insulin release and glycemia: physiological role and therapeutic potential.

Yada T, Dezaki K, Sone H, Koizumi M, Damdindorj B, Nakata M, Kakei M.

Curr Diabetes Rev. 2008 Feb;4(1):18-23. Review.

PMID:
18220691
19.

A molecular link between the common phenotypes of type 1 glycogen storage disease and HNF1alpha-null mice.

Hiraiwa H, Pan CJ, Lin B, Akiyama TE, Gonzalez FJ, Chou JY.

J Biol Chem. 2001 Mar 16;276(11):7963-7. Epub 2000 Dec 19.

20.

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice.

Pontoglio M, Sreenan S, Roe M, Pugh W, Ostrega D, Doyen A, Pick AJ, Baldwin A, Velho G, Froguel P, Levisetti M, Bonner-Weir S, Bell GI, Yaniv M, Polonsky KS.

J Clin Invest. 1998 May 15;101(10):2215-22.

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