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Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.

O'Regan L, Sampson J, Richards MW, Knebel A, Roth D, Hood FE, Straube A, Royle SJ, Bayliss R, Fry AM.

J Cell Biol. 2015 May 11;209(3):349-58. doi: 10.1083/jcb.201409151. Epub 2015 May 4.


Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release.

Mukherjee M, Sabir S, O'Regan L, Sampson J, Richards MW, Huguenin-Dezot N, Ault JR, Chin JW, Zhuravleva A, Fry AM, Bayliss R.

Sci Signal. 2018 Aug 14;11(543). pii: eaao2464. doi: 10.1126/scisignal.aao2464.


The microtubule-associated protein EML3 regulates mitotic spindle assembly by recruiting the Augmin complex to spindle microtubules.

Luo J, Yang B, Xin G, Sun M, Zhang B, Guo X, Jiang Q, Zhang C.

J Biol Chem. 2019 Apr 5;294(14):5643-5656. doi: 10.1074/jbc.RA118.007164. Epub 2019 Feb 5.


Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells.

Sampson J, O'Regan L, Dyer MJS, Bayliss R, Fry AM.

Cancer Res. 2017 Sep 15;77(18):4785-4796. doi: 10.1158/0008-5472.CAN-16-3233. Epub 2017 Jul 18.


A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging.

Booth DG, Hood FE, Prior IA, Royle SJ.

EMBO J. 2011 Mar 2;30(5):906-19. doi: 10.1038/emboj.2011.15. Epub 2011 Feb 4.


Hsp70 proteins in mitosis and disease.

O'Regan L, Sampson J, Fry AM.

Oncotarget. 2015 Oct 20;6(32):32293-4. doi: 10.18632/oncotarget.5965. No abstract available.


Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension.

Cheeseman LP, Harry EF, McAinsh AD, Prior IA, Royle SJ.

J Cell Sci. 2013 May 1;126(Pt 9):2102-13. doi: 10.1242/jcs.124834. Epub 2013 Mar 26.


Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly.

Burgess SG, Peset I, Joseph N, Cavazza T, Vernos I, Pfuhl M, Gergely F, Bayliss R.

PLoS Genet. 2015 Jul 2;11(7):e1005345. doi: 10.1371/journal.pgen.1005345. eCollection 2015 Jul.


The role of TACC3 in mitotic spindle organization.

Ding ZM, Huang CJ, Jiao XF, Wu D, Huo LJ.

Cytoskeleton (Hoboken). 2017 Oct;74(10):369-378. doi: 10.1002/cm.21388. Epub 2017 Aug 23. Review.


The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability.

Du J, Cai X, Yao J, Ding X, Wu Q, Pei S, Jiang K, Zhang Y, Wang W, Shi Y, Lai Y, Shen J, Teng M, Huang H, Fei Q, Reddy ES, Zhu J, Jin C, Yao X.

Oncogene. 2008 Jul 3;27(29):4107-14. doi: 10.1038/onc.2008.34. Epub 2008 Feb 25.


The microtubule-associated protein HURP recruits the centrosomal protein TACC3 to regulate K-fiber formation and support chromosome congression.

Zhang Y, Tan L, Yang Q, Li C, Liou YC.

J Biol Chem. 2018 Oct 5;293(40):15733-15747. doi: 10.1074/jbc.RA118.003676. Epub 2018 Jul 27.


Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.

Lin CH, Hu CK, Shih HM.

J Cell Biol. 2010 Jun 28;189(7):1097-105. doi: 10.1083/jcb.200911120. Epub 2010 Jun 21.


The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.

O'Regan L, Fry AM.

Mol Cell Biol. 2009 Jul;29(14):3975-90. doi: 10.1128/MCB.01867-08. Epub 2009 May 4.


FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle.

Zhu H, Coppinger JA, Jang CY, Yates JR 3rd, Fang G.

J Cell Biol. 2008 Dec 1;183(5):835-48. doi: 10.1083/jcb.200807046. Epub 2008 Nov 24.


Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly.

Fu W, Chen H, Wang G, Luo J, Deng Z, Xin G, Xu N, Guo X, Lei J, Jiang Q, Zhang C.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15295-300. doi: 10.1073/pnas.1312382110. Epub 2013 Sep 3.


The nuclear scaffold protein SAF-A is required for kinetochore-microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles.

Ma N, Matsunaga S, Morimoto A, Sakashita G, Urano T, Uchiyama S, Fukui K.

J Cell Sci. 2011 Feb 1;124(Pt 3):394-404. doi: 10.1242/jcs.063347.


Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding.

Hood FE, Williams SJ, Burgess SG, Richards MW, Roth D, Straube A, Pfuhl M, Bayliss R, Royle SJ.

J Cell Biol. 2013 Aug 5;202(3):463-78. doi: 10.1083/jcb.201211127.


Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis.

Fu G, Ding X, Yuan K, Aikhionbare F, Yao J, Cai X, Jiang K, Yao X.

Cell Res. 2007 Jul;17(7):608-18.


Microtubules and Alp7-Alp14 (TACC-TOG) reposition chromosomes before meiotic segregation.

Kakui Y, Sato M, Okada N, Toda T, Yamamoto M.

Nat Cell Biol. 2013 Jul;15(7):786-96. doi: 10.1038/ncb2782. Epub 2013 Jun 16.


The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle.

Nixon FM, GutiƩrrez-Caballero C, Hood FE, Booth DG, Prior IA, Royle SJ.

Elife. 2015 Jun 19;4. doi: 10.7554/eLife.07635.

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