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Items: 1 to 20 of 84

1.

Cyclopamine-loaded core-cross-linked polymeric micelles enhance radiation response in pancreatic cancer and pancreatic stellate cells.

Zhao J, Wu C, Abbruzzese J, Hwang RF, Li C.

Mol Pharm. 2015 Jun 1;12(6):2093-100. doi: 10.1021/mp500875f. Epub 2015 May 12.

2.

Chemoradiation therapy using cyclopamine-loaded liquid-lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles.

You J, Zhao J, Wen X, Wu C, Huang Q, Guan F, Wu R, Liang D, Li C.

J Control Release. 2015 Mar 28;202:40-8. doi: 10.1016/j.jconrel.2015.01.031. Epub 2015 Jan 28.

3.

Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy.

Zhao J, Wang H, Hsiao CH, Chow DS, Koay EJ, Kang Y, Wen X, Huang Q, Ma Y, Bankson JA, Ullrich SE, Overwijk W, Maitra A, Piwnica-Worms D, Fleming JB, Li C.

Biomaterials. 2018 Mar;159:215-228. doi: 10.1016/j.biomaterials.2018.01.014. Epub 2018 Jan 9.

4.

Sonic Hedgehog inhibition as a strategy to augment radiosensitivity of hepatocellular carcinoma.

Tsai CL, Hsu FM, Tzen KY, Liu WL, Cheng AL, Cheng JC.

J Gastroenterol Hepatol. 2015 Aug;30(8):1317-24. doi: 10.1111/jgh.12931.

PMID:
25682950
5.

Micellar delivery of cyclopamine and gefitinib for treating pancreatic cancer.

Chitkara D, Singh S, Kumar V, Danquah M, Behrman SW, Kumar N, Mahato RI.

Mol Pharm. 2012 Aug 6;9(8):2350-7. doi: 10.1021/mp3002792. Epub 2012 Jul 23.

PMID:
22780906
6.

Stromal Modulation Reverses Primary Resistance to Immune Checkpoint Blockade in Pancreatic Cancer.

Zhao J, Xiao Z, Li T, Chen H, Yuan Y, Wang YA, Hsiao CH, Chow DS, Overwijk WW, Li C.

ACS Nano. 2018 Oct 23;12(10):9881-9893. doi: 10.1021/acsnano.8b02481. Epub 2018 Sep 21.

PMID:
30231203
7.
8.

Codelivery of small molecule hedgehog inhibitor and miRNA for treating pancreatic cancer.

Kumar V, Mondal G, Slavik P, Rachagani S, Batra SK, Mahato RI.

Mol Pharm. 2015 Apr 6;12(4):1289-98. doi: 10.1021/mp500847s. Epub 2015 Feb 25.

9.

Copolymeric micelles for delivery of EGCG and cyclopamine to pancreatic cancer cells.

Sun L, Zhang C, Li P.

Nutr Cancer. 2014;66(5):896-903. doi: 10.1080/01635581.2014.904908. Epub 2014 May 5.

PMID:
24798568
10.

Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells.

Nakamura K, Sasajima J, Mizukami Y, Sugiyama Y, Yamazaki M, Fujii R, Kawamoto T, Koizumi K, Sato K, Fujiya M, Sasaki K, Tanno S, Okumura T, Shimizu N, Kawabe J, Karasaki H, Kono T, Ii M, Bardeesy N, Chung DC, Kohgo Y.

PLoS One. 2010 Jan 21;5(1):e8824. doi: 10.1371/journal.pone.0008824.

11.

Effect of gemcitabine and retinoic acid loaded PAMAM dendrimer-coated magnetic nanoparticles on pancreatic cancer and stellate cell lines.

Yalçin S, Erkan M, Ünsoy G, Parsian M, Kleeff J, Gündüz U.

Biomed Pharmacother. 2014 Jul;68(6):737-43. doi: 10.1016/j.biopha.2014.07.003. Epub 2014 Jul 15.

PMID:
25108345
12.

Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness.

Lonardo E, Frias-Aldeguer J, Hermann PC, Heeschen C.

Cell Cycle. 2012 Apr 1;11(7):1282-90. doi: 10.4161/cc.19679. Epub 2012 Apr 1.

PMID:
22421149
13.

[The impact of desmoplasia and pancreatic stellate cells on pancreatic cancer].

Nielsen MF, Mortensen MB, Detlefsen S.

Ugeskr Laeger. 2015 Aug 17;177(34). pii: V01150079. Review. Danish.

PMID:
26320589
14.

Modulation of Sonic hedgehog signaling and WW domain containing oxidoreductase WOX1 expression enhances radiosensitivity of human glioblastoma cells.

Chiang MF, Chen HH, Chi CW, Sze CI, Hsu ML, Shieh HR, Lin CP, Tsai JT, Chen YJ.

Exp Biol Med (Maywood). 2015 Mar;240(3):392-9. doi: 10.1177/1535370214565989. Epub 2015 Jan 16.

15.

Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model.

Guimaraes AR, Rakhlin E, Weissleder R, Thayer SP.

Pancreas. 2008 Nov;37(4):440-4. doi: 10.1097/MPA.0b013e31817c5113.

16.

Cyclopamine increases the cytotoxic effects of paclitaxel and radiation but not cisplatin and gemcitabine in Hedgehog expressing pancreatic cancer cells.

Shafaee Z, Schmidt H, Du W, Posner M, Weichselbaum R.

Cancer Chemother Pharmacol. 2006 Dec;58(6):765-70. Epub 2006 Mar 22.

PMID:
16552573
17.

Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas.

Bahra M, Kamphues C, Boas-Knoop S, Lippert S, Esendik U, Schüller U, Hartmann W, Waha A, Neuhaus P, Heppner F, Pietsch T, Koch A.

Pancreas. 2012 Mar;41(2):222-9. doi: 10.1097/MPA.0b013e31822896dd.

PMID:
22076568
18.

Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer.

Steg A, Amm HM, Novak Z, Frost AR, Johnson MR.

Cancer Biol Ther. 2010 Nov 1;10(9):893-902. doi: 10.4161/cbt.10.9.13252. Epub 2010 Nov 1.

19.

Pancreatic stellate cells and pancreas cancer: current perspectives and future strategies.

Haqq J, Howells LM, Garcea G, Metcalfe MS, Steward WP, Dennison AR.

Eur J Cancer. 2014 Oct;50(15):2570-82. doi: 10.1016/j.ejca.2014.06.021. Epub 2014 Aug 1. Review.

PMID:
25091797
20.

Sonic hedgehog paracrine signaling activates stromal cells to promote perineural invasion in pancreatic cancer.

Li X, Wang Z, Ma Q, Xu Q, Liu H, Duan W, Lei J, Ma J, Wang X, Lv S, Han L, Li W, Guo J, Guo K, Zhang D, Wu E, Xie K.

Clin Cancer Res. 2014 Aug 15;20(16):4326-38. doi: 10.1158/1078-0432.CCR-13-3426. Epub 2014 Jun 19.

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